C624 Biochemistry Module 3 Exam
Questions with complete solutions (2024-
2025)
Describe jthe jfunctions jof jhemoglobin jand jmyoglobin. j- jANS✓✓-Hemoglobin
jtransports joxygen, jMyoglobin jstores joxygen.
The jcorrect jnumber jof jsubunits, jheme jgroups, jiron jand joxygen jthat jbind jto
jhemoglobin jversus jmyoglobin. j- jANS✓✓-Hemoglobin jhas:
j4 jsubunits j
4 jheme jgroups
4 jiron jmolecules
binds j4 jmolecules jof joxygen. j
Myoglobin jhas:
j1 jsubunit
1 jheme jgroup
1 jiron jmolecule
binds j1 jmolecule jof joxygen.
Cooperativity j- jANS✓✓-Hemoglobin jcan jbind jsubsequent jmolecules jof joxygen
jmore jeasily jafter jthe jfirst joxygen jmolecule jbinds.
Which jstatement jabout jhemoglobin jbinding jto jcarbon jmonoxide j(CO) jis jtrue? j-
jANS✓✓-Hb jbinds jto jCO jwith ja jhigher jaffinity jthan joxygen jand jstabilizes jthe
jR-state.
Carbon jmonoxide jis jpoisonous jbecause j- jANS✓✓-it jbinds jhemoglobin j200
jtimes jbetter jthan joxygen.
2,3 jBPG jstabilizes jthe j_____ jstate(s) jof jhemoglobin. j- jANS✓✓-T jstate
Even jthough jthe jamino jacid jsequence jbetween jsubunits jof jhemoglobin jand
jmyoglobin jare jnot jexactly jthe jsame, jthere jare jother jsimilarities jbetween jthe
jtwo jproteins. jWhich jlevel jof jprotein jstructure jis jnot jfound jin jboth jmolecules? j-
jANS✓✓-Quaternary
In jthe jdeoxygenated jstate jthe jHeme jis j____________, jwhere jas jin jthe
joxygenated jstate, jthe jheme jis j_____________________. j- jANS✓✓-bent j(non-
planar), jplanar
, Fetal jhemoglobin j__________ j- jANS✓✓-binds jto joxygen jtightly jat jlower
joxygen jconcentrations jsince jits jR-state jis jthe jpreferred jstructure.
When jthe jblood jpH jis jlow, jthe jheme jis jin_______________ jshape. jWhen jthe
jblood jpH jis jhigh, jthe jheme jis jin j______________shape. j- jANS✓✓-bent j(non-
planar), jplanar
When jhemoglobin jchanges jfrom jT jto jR, jit jhas j________ jaffinity jfor joxygen. j-
jANS✓✓-high
When jhemoglobin jchanges jfrom jR jto jT, jit jhas j_______________ jaffinity jfor
joxygen. j- jANS✓✓-low
Cooperativity jrefers jto j________. j- jANS✓✓-Hemoglobin jstructural jchanges jthat
jincrease jits jaffinity jfor joxygen
The jBohr jeffect jis ja jrelationship jbetween jhemoglobin's joxygen jbinding
jbehavior jin jconjunction jwith jthe jpH jof jthe jsurroundings. jWhen jthe jpH jis jlow,
jhemoglobin jhas j_____________ jaffinity jfor joxygen jand j________ joxygen. j-
jANS✓✓-low, jreleases
The jBohr jeffect jis ja jrelationship jbetween jhemoglobin's joxygen jbinding
jbehavior jin jconjunction jwith jthe jpH jof jthe jsurroundings. jWhen jthe jpH jis jhigh,
jhemoglobin jhas j_____________ jaffinity jfor joxygen jand j________ joxygen. j-
jANS✓✓-high, jbinds
The jpH jin jlungs jis j_______________ jand jthe jpH jin jtissues jis j_____________. j-
jANS✓✓-high, jlow
The jBohr jeffect jis ja jrelationship jbetween jhemoglobin's joxygen jbinding
jbehavior jin jconjunction jwith jthe jpH jof jthe jsurroundings. jWhen jthe jH+ jion
jconcentration jincreases, jthe jpH jof jthe jsolution j_________________. j- jANS✓✓-
decreases
Myoglobin jstores joxygen, jwhereas jhemoglobin jtransports joxygen. jWhich jone
jof jthe jfollowing jstatements jis jtrue? j- jANS✓✓-Myoglobin jhas ja jhigher jaffinity
jfor joxygen jcompared jto jhemoglobin.
. jHemoglobin jis jan joxygen jtransport jprotein, jwhereas jmyoglobin jis jan joxygen
jstorage jprotein. jThey jexhibit jdifferent jbinding jcurves jwhen jplotted jon ja jgraph
jwith jtotal jpartial jpressure jof jthe joxygen j(x-axis) jplotted jagainst jthe jpercentage
jsaturation jof jhemoglobin j(y-axis). jWhich jpattern jof jbinding jcurves jdo jthese
jproteins jexhibit? j- jANS✓✓-Hemoglobin jhas ja jsigmoidal jcurve, jwhereas
jmyoglobin jhas ja jhyperbolic jcurve
The jsymptoms jof jsickle jcell janemia jare jprimarily jbecause jred jblood jcells jare
jmisshaped. jThis jis jdue jto j________ j- jANS✓✓-a jmutation jin jthe jbeta
Questions with complete solutions (2024-
2025)
Describe jthe jfunctions jof jhemoglobin jand jmyoglobin. j- jANS✓✓-Hemoglobin
jtransports joxygen, jMyoglobin jstores joxygen.
The jcorrect jnumber jof jsubunits, jheme jgroups, jiron jand joxygen jthat jbind jto
jhemoglobin jversus jmyoglobin. j- jANS✓✓-Hemoglobin jhas:
j4 jsubunits j
4 jheme jgroups
4 jiron jmolecules
binds j4 jmolecules jof joxygen. j
Myoglobin jhas:
j1 jsubunit
1 jheme jgroup
1 jiron jmolecule
binds j1 jmolecule jof joxygen.
Cooperativity j- jANS✓✓-Hemoglobin jcan jbind jsubsequent jmolecules jof joxygen
jmore jeasily jafter jthe jfirst joxygen jmolecule jbinds.
Which jstatement jabout jhemoglobin jbinding jto jcarbon jmonoxide j(CO) jis jtrue? j-
jANS✓✓-Hb jbinds jto jCO jwith ja jhigher jaffinity jthan joxygen jand jstabilizes jthe
jR-state.
Carbon jmonoxide jis jpoisonous jbecause j- jANS✓✓-it jbinds jhemoglobin j200
jtimes jbetter jthan joxygen.
2,3 jBPG jstabilizes jthe j_____ jstate(s) jof jhemoglobin. j- jANS✓✓-T jstate
Even jthough jthe jamino jacid jsequence jbetween jsubunits jof jhemoglobin jand
jmyoglobin jare jnot jexactly jthe jsame, jthere jare jother jsimilarities jbetween jthe
jtwo jproteins. jWhich jlevel jof jprotein jstructure jis jnot jfound jin jboth jmolecules? j-
jANS✓✓-Quaternary
In jthe jdeoxygenated jstate jthe jHeme jis j____________, jwhere jas jin jthe
joxygenated jstate, jthe jheme jis j_____________________. j- jANS✓✓-bent j(non-
planar), jplanar
, Fetal jhemoglobin j__________ j- jANS✓✓-binds jto joxygen jtightly jat jlower
joxygen jconcentrations jsince jits jR-state jis jthe jpreferred jstructure.
When jthe jblood jpH jis jlow, jthe jheme jis jin_______________ jshape. jWhen jthe
jblood jpH jis jhigh, jthe jheme jis jin j______________shape. j- jANS✓✓-bent j(non-
planar), jplanar
When jhemoglobin jchanges jfrom jT jto jR, jit jhas j________ jaffinity jfor joxygen. j-
jANS✓✓-high
When jhemoglobin jchanges jfrom jR jto jT, jit jhas j_______________ jaffinity jfor
joxygen. j- jANS✓✓-low
Cooperativity jrefers jto j________. j- jANS✓✓-Hemoglobin jstructural jchanges jthat
jincrease jits jaffinity jfor joxygen
The jBohr jeffect jis ja jrelationship jbetween jhemoglobin's joxygen jbinding
jbehavior jin jconjunction jwith jthe jpH jof jthe jsurroundings. jWhen jthe jpH jis jlow,
jhemoglobin jhas j_____________ jaffinity jfor joxygen jand j________ joxygen. j-
jANS✓✓-low, jreleases
The jBohr jeffect jis ja jrelationship jbetween jhemoglobin's joxygen jbinding
jbehavior jin jconjunction jwith jthe jpH jof jthe jsurroundings. jWhen jthe jpH jis jhigh,
jhemoglobin jhas j_____________ jaffinity jfor joxygen jand j________ joxygen. j-
jANS✓✓-high, jbinds
The jpH jin jlungs jis j_______________ jand jthe jpH jin jtissues jis j_____________. j-
jANS✓✓-high, jlow
The jBohr jeffect jis ja jrelationship jbetween jhemoglobin's joxygen jbinding
jbehavior jin jconjunction jwith jthe jpH jof jthe jsurroundings. jWhen jthe jH+ jion
jconcentration jincreases, jthe jpH jof jthe jsolution j_________________. j- jANS✓✓-
decreases
Myoglobin jstores joxygen, jwhereas jhemoglobin jtransports joxygen. jWhich jone
jof jthe jfollowing jstatements jis jtrue? j- jANS✓✓-Myoglobin jhas ja jhigher jaffinity
jfor joxygen jcompared jto jhemoglobin.
. jHemoglobin jis jan joxygen jtransport jprotein, jwhereas jmyoglobin jis jan joxygen
jstorage jprotein. jThey jexhibit jdifferent jbinding jcurves jwhen jplotted jon ja jgraph
jwith jtotal jpartial jpressure jof jthe joxygen j(x-axis) jplotted jagainst jthe jpercentage
jsaturation jof jhemoglobin j(y-axis). jWhich jpattern jof jbinding jcurves jdo jthese
jproteins jexhibit? j- jANS✓✓-Hemoglobin jhas ja jsigmoidal jcurve, jwhereas
jmyoglobin jhas ja jhyperbolic jcurve
The jsymptoms jof jsickle jcell janemia jare jprimarily jbecause jred jblood jcells jare
jmisshaped. jThis jis jdue jto j________ j- jANS✓✓-a jmutation jin jthe jbeta
