BMS 300 EXAM3 QUESTIONSANDANSWERS

BMS 300 EXAM3 QUESTIONSANDANSWERSWhat are the sex determinants in females XX? - ANSWER Rspo1 andWnt4/ Beta-catenin What are the sex determinants in males XY? - ANSWER Sry and Sox9PGC differentiation in XX - ANSWER Mesonephros -- Retinoic Acid--Gonad -- no CYP26B1 -- Meiotic entry PGCs Differentiation of Primordial Germ Cell (PGC), XY - ANSWERMesonephros-- Retinoic Acid -- Gonad --CYP26B1 -- No Meiotic entry PGCs True or False? Primary/Gonad sex differentiation does NOT depend onPGCdifferentiation. - ANSWER True Developed by Wolffian Duct - ANSWER Epididymis (Testis), Vas Deferenes, Seminal Vesicle Developed by Mullerian Duct - ANSWER Ovary (Oviduct/ "FallopianTube"), Uterus, Upper 1/3 of Vagina Removing the gonads of rabbits shows us that: - ANSWER The ovary does nothing in development BMS 300 EXAM3 QUESTIONSANDANSWERS ONLYSTRUDENTS STORE 2025 ALL THE BEST ONLYSTRUDENTS STORE 2 DO NOT COPY ANSWER Male development is greatly dependant upon testosterone. Removal of the gonads of rabbits, taking testis fragments and putting thembackin, shows us that: - ANSWER Anti-Mullerian Hormone is present andsecretedby Sertoli cells and gets ride of the Mullerian Duct. External genitalia development can be bi-potential. Bi-potential means that: - ANSWER Either one of the two outcomes is possible, it just depends onthefactors present, and what is released, and what is blocked. Androgen Insensitivity Syndrome (testicular feminization syndrome) - ANSWER Mutation in androgen receptor that causes: Chromosomal Sex: XX Gonadal Sex: Undescended testes Phenotypic Sex: female Androgen - ANSWER Sex Steroid Hormone. Testosterone (ovaries andtestes). Dihydrotestosterone. Estrogen - ANSWER Sex Steroid Hormone. Estradiol (ovaries and testes). Progesterone - ANSWER Sex Steroid Hormone. Precursor. Removing the gonads of rabbits, and adding testosterone shows us that: - ONLYSTRUDENTS STORE 2025 ALL THE BEST ONLYSTRUDENTS STORE 3 DO NOT COPY Where is sperm produced? - ANSWER Seminiferous tubules. Where is testosterone produced? - ANSWER Interstitial space. What are the functions of the testis that keep them at a lower temperaturethanthe body to ensure not to kill the sperm? - ANSWER Pampiniformplexus (acountercurrent) and testicular descent (raising and lowering testis basedontemperature of body/surroundings). What is involved with the countercurrent exchange? - ANSWERTesticular arteries and veins. What is involved with testicular descent? - ANSWER Abdominal translocation(Insulin-like 3 "Insl3"), transinguinal migration, and inguinsocrotal migration(testosterone). What is within the testicular cords? - ANSWER Gonocytes and Sertoli cellsWhat is within the interstitium? - ANSWER Leydig cells and blood vesselsSertoli Cell Functions - ANSWER Form tight junctions (blood testis barrier), support germ cells (physically + nutrition), secrete fluids, secrete inhibin(feedback to the brain), phagocytose defective sperm, and secrete androgenbinding protein. In fetal life it secretes AMH.