USMLE STEP 1 FIRST AID: CLASSIC
PRESENTATIONS FLASH CARDS EXAM
Q&A 100% SOLVED
Name the disease associated most like associated with the following
symptoms:
Abdominal Pain, Ascites, Hepatomegaly - ✔✔Budd-Chiari syndrome
(posthepatic venous thrombosis)
Abdominal pain, diarrhea, leukocytosis, recent antibiotic use -
✔✔Clostridium dificile
Name the disease associated most like associated with the following
symptoms:
Achilles Tendon Xanthoma - ✔✔Familial hypercholesteremia (Decreased
LDL receptor signaling)
1
©JOSHCLAY 2024/2025. YEAR PUBLISHED 2024.
,Adrenal Hemorrhage, hypotension, DIC - ✔✔Waterhouse-Friedrichson
Syndrome (Meningicoccemia) Typical bacteria is Neisseria meningitidis
Anaphylaxis following a blood transfusion - ✔✔IgA Deficiency
To note: The prevalence of celiac disease in patients with selective IgA
deficiency ranges from 10% to 30%
Anterior "drawer sign" - ✔✔Anterior cruciate ligament
Arachnodactyly, lens dislocation, aortic dissection, hyperflexible joins -
✔✔Marfan syndrome (fibrillin defect)
FBN1 gene on chromosome 15 which encodes fibrillin-1, a glycoprotein
component of the extracellular matrix & sequestering transforming growth
factor beta (TGF-β)
Athlete with polycytheme - ✔✔Secondary to EPO injections
Back pain, fever, night sweats - ✔✔Pott disease (vertebral TB)
Bilateral Acoustic Schwannomas - ✔✔Neurofibromatosis 2
Bilateral hilar adenopathy, uveitis - ✔✔Sarcoidosis (noncaseating
granuloma)
2
©JOSHCLAY 2024/2025. YEAR PUBLISHED 2024.
, Black eschar on on patient with diabetic ketoacidosis - ✔✔Mucor or
Rhizopus fungal infection
Blue sclera - ✔✔Osteogenesis imperfecta (type I collagen defect)
Most cases are caused by mutations in the COL1A1 and COL1A2 genes.
Bluish line on gingiva - ✔✔Burton line (lead poisoining)
Bone pain, bone enlargement, arthritis - ✔✔Paget's Disease of Bone
(increased osteoblastic AND osteoclastic activity)
Paget's disease may be caused by a slow virus infection (i.e.,
paramyxoviridae) present for many years before symptoms appear.
Associated viral infections: RSV,
Paget's disease of bone also can be genetic: SQSTM1 and RANK, and
specific regions of chromosome 5 and 6.
Bounding pulses, diastolic heart murmur, head bobbing - ✔✔Aortic
regurgitation
Butterfly rash and Raynaud's phenomenon in a young female -
✔✔Systemic Lupus Erythemtosus
3
©JOSHCLAY 2024/2025. YEAR PUBLISHED 2024.
PRESENTATIONS FLASH CARDS EXAM
Q&A 100% SOLVED
Name the disease associated most like associated with the following
symptoms:
Abdominal Pain, Ascites, Hepatomegaly - ✔✔Budd-Chiari syndrome
(posthepatic venous thrombosis)
Abdominal pain, diarrhea, leukocytosis, recent antibiotic use -
✔✔Clostridium dificile
Name the disease associated most like associated with the following
symptoms:
Achilles Tendon Xanthoma - ✔✔Familial hypercholesteremia (Decreased
LDL receptor signaling)
1
©JOSHCLAY 2024/2025. YEAR PUBLISHED 2024.
,Adrenal Hemorrhage, hypotension, DIC - ✔✔Waterhouse-Friedrichson
Syndrome (Meningicoccemia) Typical bacteria is Neisseria meningitidis
Anaphylaxis following a blood transfusion - ✔✔IgA Deficiency
To note: The prevalence of celiac disease in patients with selective IgA
deficiency ranges from 10% to 30%
Anterior "drawer sign" - ✔✔Anterior cruciate ligament
Arachnodactyly, lens dislocation, aortic dissection, hyperflexible joins -
✔✔Marfan syndrome (fibrillin defect)
FBN1 gene on chromosome 15 which encodes fibrillin-1, a glycoprotein
component of the extracellular matrix & sequestering transforming growth
factor beta (TGF-β)
Athlete with polycytheme - ✔✔Secondary to EPO injections
Back pain, fever, night sweats - ✔✔Pott disease (vertebral TB)
Bilateral Acoustic Schwannomas - ✔✔Neurofibromatosis 2
Bilateral hilar adenopathy, uveitis - ✔✔Sarcoidosis (noncaseating
granuloma)
2
©JOSHCLAY 2024/2025. YEAR PUBLISHED 2024.
, Black eschar on on patient with diabetic ketoacidosis - ✔✔Mucor or
Rhizopus fungal infection
Blue sclera - ✔✔Osteogenesis imperfecta (type I collagen defect)
Most cases are caused by mutations in the COL1A1 and COL1A2 genes.
Bluish line on gingiva - ✔✔Burton line (lead poisoining)
Bone pain, bone enlargement, arthritis - ✔✔Paget's Disease of Bone
(increased osteoblastic AND osteoclastic activity)
Paget's disease may be caused by a slow virus infection (i.e.,
paramyxoviridae) present for many years before symptoms appear.
Associated viral infections: RSV,
Paget's disease of bone also can be genetic: SQSTM1 and RANK, and
specific regions of chromosome 5 and 6.
Bounding pulses, diastolic heart murmur, head bobbing - ✔✔Aortic
regurgitation
Butterfly rash and Raynaud's phenomenon in a young female -
✔✔Systemic Lupus Erythemtosus
3
©JOSHCLAY 2024/2025. YEAR PUBLISHED 2024.
