, Chapter 1: Principles of Pharmacology x x x x
Multiple Choice x
1. x refer(s) to specific molecular changes that occur when a drug binds to a
x x x x x x x x x x x x
xparticular target site or receptor, while
x are the resulting widespread alterations
x x x x x x x x
in function.
x x
a. Drug action; therapeutic effects
x x x
b. Side effects; drug effects
x x x
c. Therapeutic effects; side effects x x x
d. Drug action; drug effectsx x x
Answer: d x
Textbook Reference: Pharmacology: The Science of Drug Action
x x x x x x x
2. After drug administration has occurred, the amount of drug in the blood that is free to
x x x x x x x x x x x x x x x
bind at specific target sites is referred to as
x x x x x x x x x
a. the therapeutic dose.
x x
b. first-pass effects. x
c. bioavailability.
d. ED50.
Answer: c x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
3. The specific molecular changes that occur when a drug binds to a particular target site
x x x x x x x x x x x x x x
or receptor are referred to as
x x x x x x
a. drug effects. x
b. drug action. x
c. side effects. x
d. placebo effects. x
Answer: b x
Textbook Reference: Pharmacology: The Science of Drug Action
x x x x x x x
4. Which of the following is not a possible explanation for placebo effects?
x x x x x x x x x x x
a. Pavlovian conditioning x
b. Genetic variation x
c. Drug competition x
d. Expectation of outcome x x
Answer: c x
Textbook Reference: Pharmacology: The Science of Drug Action
x x x x x x x
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x x x
,5. The administration of oxytocin has been proposed as a treatment for autism. x x x x x x x x x x
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
6. Which factor does not affect the pharmacokinetics of a drug?
x x x x x x x x x
a. Route of administration
x x
b. Lipid solubility
x
c. Depot binding x
d. Drug actionx
Answer: d x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
7. First-pass metabolism occurs when drugs are taken
x x x x x x
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
8. The area postrema is one area in the brain where the
x x is not complete.
x x x x x x x x x x
a. cerebrospinal fluid x
b. blood–brain barrier x
c. choroid plexus x
d. phospholipid membrane x
Answer: b x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
9. First-pass metabolism occurs with orally administered drugs because
x x x x x x x
a. their absorption is slowed by food.
x x x x x
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to
x x x x x x x x x x x x x x x
general circulation.
x x
c. drugs must first survive the acidic environment of the stomach.
x x x x x x x x x
d. salivary enzymes in the mouth begin the process of metabolism.
x x x x x x x x x
Answer: b x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
10. Toxic substances in the blood trigger a vomiting response by activating the
x x x x x x x x x x x
a. blood–brain barrier. x
b. choroid plexus. x
c. area postrema.
x
d. median eminence. x
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x x x
, Answer: c x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
11. Drugs administered _ have the most rapid onset of action.
x x x x x x x x
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
12. Ionization of a drug depends on the of the solution and the
x x x x x x x x x x of the
x
drug.
x
a. pH; pKa
x
b. pKa; pH x
c. concentration; lipid solubility x x
d. pH; concentration
x
Answer: a x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
13. The absorption of a drug depends on all of the following except
x x x x x x x x x x x
a. lipid solubility.
x
b. ionization.
c. body temperature.
x
d. the concentration of the drug.
x x x x
Answer: c x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
14. Drugs that are should be avoided by women of childbearing age.
x x x x x x x x x
a. teratogenic
b. able to cross the placental barrier
x x x x x
c. psychoactive
d. highly lipid-soluble x
Answer: a x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
15. Agents that induce developmental abnormalities in a fetus are known as
x x x x x x x x x x
a. psychoactive drugs. x
b. illicit drugs. x
c. teratogens.
d. placental drugs. x
Answer: c x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
16. Depot binding is said to occur when drugs
x x x x x x x
a. bind to their target sites.
x x x x
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x x x
Multiple Choice x
1. x refer(s) to specific molecular changes that occur when a drug binds to a
x x x x x x x x x x x x
xparticular target site or receptor, while
x are the resulting widespread alterations
x x x x x x x x
in function.
x x
a. Drug action; therapeutic effects
x x x
b. Side effects; drug effects
x x x
c. Therapeutic effects; side effects x x x
d. Drug action; drug effectsx x x
Answer: d x
Textbook Reference: Pharmacology: The Science of Drug Action
x x x x x x x
2. After drug administration has occurred, the amount of drug in the blood that is free to
x x x x x x x x x x x x x x x
bind at specific target sites is referred to as
x x x x x x x x x
a. the therapeutic dose.
x x
b. first-pass effects. x
c. bioavailability.
d. ED50.
Answer: c x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
3. The specific molecular changes that occur when a drug binds to a particular target site
x x x x x x x x x x x x x x
or receptor are referred to as
x x x x x x
a. drug effects. x
b. drug action. x
c. side effects. x
d. placebo effects. x
Answer: b x
Textbook Reference: Pharmacology: The Science of Drug Action
x x x x x x x
4. Which of the following is not a possible explanation for placebo effects?
x x x x x x x x x x x
a. Pavlovian conditioning x
b. Genetic variation x
c. Drug competition x
d. Expectation of outcome x x
Answer: c x
Textbook Reference: Pharmacology: The Science of Drug Action
x x x x x x x
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Page 1 of 247
x x x
,5. The administration of oxytocin has been proposed as a treatment for autism. x x x x x x x x x x
a. intravenous
b. oral
c. intranasal
d. intracerebral
Answer: c x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
6. Which factor does not affect the pharmacokinetics of a drug?
x x x x x x x x x
a. Route of administration
x x
b. Lipid solubility
x
c. Depot binding x
d. Drug actionx
Answer: d x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
7. First-pass metabolism occurs when drugs are taken
x x x x x x
a. orally.
b. intravenously.
c. subcutaneously.
d. nasally.
Answer: a x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
8. The area postrema is one area in the brain where the
x x is not complete.
x x x x x x x x x x
a. cerebrospinal fluid x
b. blood–brain barrier x
c. choroid plexus x
d. phospholipid membrane x
Answer: b x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
9. First-pass metabolism occurs with orally administered drugs because
x x x x x x x
a. their absorption is slowed by food.
x x x x x
b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to
x x x x x x x x x x x x x x x
general circulation.
x x
c. drugs must first survive the acidic environment of the stomach.
x x x x x x x x x
d. salivary enzymes in the mouth begin the process of metabolism.
x x x x x x x x x
Answer: b x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
10. Toxic substances in the blood trigger a vomiting response by activating the
x x x x x x x x x x x
a. blood–brain barrier. x
b. choroid plexus. x
c. area postrema.
x
d. median eminence. x
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Page 2 of 247
x x x
, Answer: c x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
11. Drugs administered _ have the most rapid onset of action.
x x x x x x x x
a. subcutaneously
b. intramuscularly
c. orally
d. intravenously
Answer: d x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
12. Ionization of a drug depends on the of the solution and the
x x x x x x x x x x of the
x
drug.
x
a. pH; pKa
x
b. pKa; pH x
c. concentration; lipid solubility x x
d. pH; concentration
x
Answer: a x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
13. The absorption of a drug depends on all of the following except
x x x x x x x x x x x
a. lipid solubility.
x
b. ionization.
c. body temperature.
x
d. the concentration of the drug.
x x x x
Answer: c x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
14. Drugs that are should be avoided by women of childbearing age.
x x x x x x x x x
a. teratogenic
b. able to cross the placental barrier
x x x x x
c. psychoactive
d. highly lipid-soluble x
Answer: a x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
15. Agents that induce developmental abnormalities in a fetus are known as
x x x x x x x x x x
a. psychoactive drugs. x
b. illicit drugs. x
c. teratogens.
d. placental drugs. x
Answer: c x
Textbook Reference: Pharmacokinetic Factors Determining Drug Action
x x x x x x
16. Depot binding is said to occur when drugs
x x x x x x x
a. bind to their target sites.
x x x x
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x x x
