Questions with Verified Answers.
What does the Black Box warning of Carbamazepine cover ? - Agranulocytosis
Aplastic Anemia
What are the signs and symptoms of aplastic anemia? - pallor, fatigue, headache, fever,
nosebleeds, bleeding gums, skin rash, shortness of breath.
Who is most at risk for Stevens Johnon syndrome with Carbamazepine? - Asians with
HLA-B* 1502 allele
In women of childbearing age, what is most important preventative with Carbamazepine
and other psychotropic medication? - To take a pregnancy test (HCG pregnancy test--
human chorionic gonadotropin)
What age is childbearing for the purpose of psychopharmaceuticals? - Ages 12-51
What is the most important supplement for women of child bearing age and especially
Pregnant women to take when they are taking psychotropic medication? - Folic Acid
which supports neural tube development during the first month that a woman is pregnant
Clozaril / Clozapine and ANC (absolute neutrophil count) - ANC < 1000 = DC because of
risk of neutropenia
WBC < 2000-3000 = DC becuase of risk of agranulocytosis
With both, monitor patients for signs of infections
What is a normal BMI? - 18.5-24.9
Is there a BMI sign of bulimia nervosa? - No. The BMI is usually within normal range of
18.5-24.9
Is there a BMI sign of Anorexia Nervosa? - Yes. Patient is usually underweight
, What are signs and symptoms of bulimia nervosa - Erosion of dental enamel
Russell's sign: scarring or calluses on dorsum of hand secondary to self-induced vomiting
Hypertrophy of salivary glands
Rectal prolapse
What way do we manage bulimia nervosa with pharmaceuticals? - Fluoxetine
Role of SSRIs and TCAs in bulimia nervosa - SSRIs and TCAs are effective in reducing
binging and purching frequency
What ae the most common signs and symptoms of Anorexia Nervosa? - Low BMI
Amenorrhea
Emaciation
bradycardia
Hypotension
What are some other common signs and symptoms of anorexia nervosa? - Inversion of T-
waves
Prolonged QT interval
Hypertrophy of salivary glands
Russell's sign
What class of antidepressants is best for depression with low energy or fatigue - NDRIs
(Norepinephrine, Dopamine, Reuptake Inhibitor)--Wellbutrin
With which patients is Wellbutrin contraindicated and why? - Seizure disorder
hx of seizures
Conditions that increase the risk of seizure such as anorexia nervosa or bulimia
Wellbutrin increases the seizure risk by decreasing the seizure threshold.
MOA for Bupropion - Boosts Norepinephrine /adrenaline and dopamine