AdvancedlPathophysiologylReview|lQsl&lAs|
lGradelA|l100%lCorrect (Verified Answers)
–lRegis
Q:lDefinelanginalpectoris
Answer:
Chestlpainlresultinglfromlalmyocardialloxygenldemandlthatlislnotlmetlbyladequateloxygenlsupp
ly;lseenlinlpatientlwithlmyocardiallischemia
Q:lWhatlislthelunderlyinglpathologylinvolvedlinlanginalpectoris?
Answer:
•lwhenltherelisldecreasedlbloodlsupplyl(oxygen)ltolthelheart,ldueltoleitherlarteriallobstructionlo
rlspasmlor
l•lwhenltherelislincreasedldemandlforloxygenlbylthelheartlor
l•lwhenltherelislalcombinationloflfactor
Q:lIdentifyldisorderslthatlmaylcauselorlpredisposelanlindividualltolangina.
Answer:
atherosclerosislarteriosclerosislvasospasmlmyocardiallhypertrophylseverelanemiaslrespiratoryldi
sease
Q:lWhatlislthelmostlseriouslcomplicationloflanginalpectoris?
Answer:
myocardiallinfarction
,Q:lsmokinglalcigarettelorlbeinglexposedltolsecondhandlsmoke
Answer:
smokelcauseslvasoconstriction,lleadingltolincreasedlvenouslreturnlandlincreasedlheartlrate
Q:lgoinglfromlalwarmlenvironmentlintolthelcold
Answer:
vasoconstriction,lleadingltolincreasedlvenouslreturnlandlincreasedlheartlrate
Q:lengaginglinlanlargumentlorlotherlstressfullbehavior
Answer:
sympatheticlstimulationlincreaseslheartlrate
Q:lexercise,lsuchlaslclimbinglalflightloflstairslorlrushingltolcatchlalbus
Answer:
increaseslheartlrateldueltolincreasedlO2ldemands
Q:lDescribelthelclassiclmanifestationsloflanlanginallattack.lWhatlislthelusualldurationloflanlan
ginallattack?
Answer:
Thelclassiclmanifestationslarelrecurrent,lintermittentlbrieflepisodesloflsubsternallchestlpain,ldes
cribedlaslaltightnesslorlpressurelthatlmaylradiateltolthelnecklorlleftlarm.lAnlanginallattacklusual
lyllastslalfewlsecondslorlminutes
,Q:lWhatltypelofldruglislusedltoltreatlanlacutelanginallattack?lExplainlhowltheseldrugslrelievel
chestlpain.
Answer:
Coronarylvasodilators,lsuchlaslnitroglycerin,lactlbylreducinglsystemiclresistance,lthusldecreasin
gltheldemandlforloxygen.lSomelvasodilatorslalsolrelievelarteriallvasospasm.lNitroglycerinlhasla
nlimmediatelonsetloflaction.
Q:lhowlwouldltoladministerlnitroglycerin?
Answer:
sublingual
Q:lOutlinelthelmanagementloflanlanginallattack.
Answer:
1.lletlptlrest,lstoplactivity
2.lseatlptlinlanlUPRIGHTlposition
3.lgivelnitroglycerinelsublingually
4.lchecklpulselandlrespiration
5.lgiveloxygenliflnecessary
6.lforlalptlwithlknownlanginalthelAHAlrecommendslalsecondldoseloflntgliflpainlpersistslforlm
orelthanl5lminutes.lAfterl3ldoseslw/inlal10lminutelperiodlandlnolrelieflitlshouldlbeltreatedlasl
MI.lCalllforlemergencylmedicallintervention
7.lForlptlw/olhxloflanginalemergencylmedicallaidlshouldlbelsoughtlafterl2lminuteslw/olrelief
Q:lWhenlshouldlemergencylmedicallservicesl(EMS)lbelrequested?
Answer:
•liflpainlislnotlrelievedlwithlrestlandladministrationloflthreeldosesloflnitroglycerinlspacedl5lmin
uteslapartl(i.e.,lafterl10lminutes)l
•lforlindividuallwithlnolhistoryloflangina,liflpainlislunrelievedlwithinl2lminutes
, Q:lListlotherltypesloflmedicationlthatlmightlbelprescribedlforlanlindividuallwithlangina,landle
xplainlthelrationalelforleach.
Answer:
•lantihypertensiveltollowerlbloodlpressurelandlcardiaclworkload
•ldiureticltolhelplcontrollbloodlpressurelandlpreventledemal
•lplateletlinhibitorltollowerlplateletlaggregationlandlthelchanceloflthrombuslformationl
•lantihyperlidemicltollowerlbloodlcholesterollandlLDLllevelslandlhopefullylslowlorlarrestlprogr
essionloflatherosclerosis
Q:lIdentifylsurgicallinterventionslthatlmightlbelusedlinltheltreatmentloflangina.
Answer:
angioplastylandlstentlinsertion;lcoronarylbypasslgraft
Q:lDescribelnonpharmacologiclinterventionslthatlcouldlhelpltolcontrollangina.
Answer:
•lAvoidlsituationslknownltolprecipitateslattacksl(e.g.,lstress).l
•lStoplsmoking.l
•lConsumeldietllowlinlsaturatedlandltrans-fats.l
•lRestrictlsodiumlintake.l
•lLoselweightlifloverweight.l
•lEngagelinlalconsistentlexerciselprogram.l
•lReducelstress.
Q:lAlpatientlstateslthatlhelhaslanginalpectoris.lIdentifyladditionallinformationlthatlshouldlbelo
btainedlfromlthislindividual.
Answer:
Howllonglhaslthelindividuallhadlangina?l
Howlfrequentlarelthelattacks?l
Whenlwaslthellastlone?l
Whatlarelthelknownlprecipitatinglfactors?l