MCB5252 Exam 2 Test With
Complete Solution
Innate immune cells include... - ANSWER Macrophages, granulocytes, natural
killer cells, dendritic cells
Innate immunity chemical mediators - ANSWER lysozyme
complement
defensins
Acquired immunity cells - ANSWER B and T cells, antigen presenting cells
(APC)
Acquired vs innate: which distinguishes self from non-self? - ANSWER
Acquired (failure results in autoimmune disease)
Innate immunity specificity - ANSWER specific for molecules and molecular
patterns associated with pathogens and molecules produced by
dead/damaged cells
Adaptive immunity specificity - ANSWER highly specific, discriminates even
minor differences in molecular structure; details of microbial or nonmicrobial
structure recognized with high specificity
Innate immunity: soluble components of blood or tissue fluids - ANSWER
many antimicrobial peptides and proteins
Adaptive immunity: soluble components of blood or tissue fluids - ANSWER
antibodies
,Sebum - ANSWER produced by skin cells; keeps the skin oily; involved in
innate immunity along with low pH
Innate immunity in small intestine - ANSWER bile salt
lactoferrin and transferrin - ANSWER By binding iron, an essential nutrient
for bacteria, these proteins limit bacterial growth.
Sequester iron in the liver and remove it from circulation (which makes you
tired because hemoglobin is less available)
Skin-associated lymphoid tissue (SALT) - ANSWER
Gut-associated lymphoid tissue (GALT) - ANSWER GALT includes Peyer's
patches in the gut and the diffuse lymphatic tissue in the gastrointestinal
tract and respiratory system
bronchial-associated lymphoid tissue (BALT) - ANSWER These neoplasms fall
under the broader umbrella of mucosa associated lymphoid tissue (MALT)
lymphomas. It is sometimes considered a type of primary pulmonary
lymphoma.
Urogenital system MALT - ANSWER a diffuse system of small concentrations
of lymphoid tissue found in various sites of the body, such as the
gastrointestinal tract, thyroid, breast, lung, salivary glands, eye, and skin.
primary lymphoid organs - ANSWER bone marrow and thymus
secondary lymphoid organs - ANSWER lymph nodes, spleen, tonsils
Monocytes, macrophages, and neutrophils are... - ANSWER phagocytic
macrophages are also antigen presenting cells
Dendritic cells - ANSWER present in small numbers in blood, skin, and
, mucous membranes of the nose, lungs, and intestines
contact and process antigens, then display on their surface for antigen
presentation
True/False: Dendritic cells come from both the myeloid and lymphoid stem
cell lines - ANSWER True
Macrophages - ANSWER long life
reside in different parts of the body - kidney, liver, lung, under the skin, etc
phagocytic
antigen-presenting
produce cytokines
Macrophages bind directly to pathogen without any other processing which
makes it quicker not to have to wait for communication from other cells.
How do they do this? (6 receptors) - ANSWER 1. LPS receptors - recognize
bacterial LPS
2. Toll-Like Receptors - recognize pathogen surface molecules - cell wall,
membrane, teichoic acid
3. Mannose receptors - recognize mannose on bacterial surface
4. Scavenger receptors - look for any sign of bacteria - directly attach
5. FC receptors (for antibodies)
6. Complement receptors
Antigen presenting cells (APCs) - ANSWER dendritic cells, macrophages, B
cells
Complete Solution
Innate immune cells include... - ANSWER Macrophages, granulocytes, natural
killer cells, dendritic cells
Innate immunity chemical mediators - ANSWER lysozyme
complement
defensins
Acquired immunity cells - ANSWER B and T cells, antigen presenting cells
(APC)
Acquired vs innate: which distinguishes self from non-self? - ANSWER
Acquired (failure results in autoimmune disease)
Innate immunity specificity - ANSWER specific for molecules and molecular
patterns associated with pathogens and molecules produced by
dead/damaged cells
Adaptive immunity specificity - ANSWER highly specific, discriminates even
minor differences in molecular structure; details of microbial or nonmicrobial
structure recognized with high specificity
Innate immunity: soluble components of blood or tissue fluids - ANSWER
many antimicrobial peptides and proteins
Adaptive immunity: soluble components of blood or tissue fluids - ANSWER
antibodies
,Sebum - ANSWER produced by skin cells; keeps the skin oily; involved in
innate immunity along with low pH
Innate immunity in small intestine - ANSWER bile salt
lactoferrin and transferrin - ANSWER By binding iron, an essential nutrient
for bacteria, these proteins limit bacterial growth.
Sequester iron in the liver and remove it from circulation (which makes you
tired because hemoglobin is less available)
Skin-associated lymphoid tissue (SALT) - ANSWER
Gut-associated lymphoid tissue (GALT) - ANSWER GALT includes Peyer's
patches in the gut and the diffuse lymphatic tissue in the gastrointestinal
tract and respiratory system
bronchial-associated lymphoid tissue (BALT) - ANSWER These neoplasms fall
under the broader umbrella of mucosa associated lymphoid tissue (MALT)
lymphomas. It is sometimes considered a type of primary pulmonary
lymphoma.
Urogenital system MALT - ANSWER a diffuse system of small concentrations
of lymphoid tissue found in various sites of the body, such as the
gastrointestinal tract, thyroid, breast, lung, salivary glands, eye, and skin.
primary lymphoid organs - ANSWER bone marrow and thymus
secondary lymphoid organs - ANSWER lymph nodes, spleen, tonsils
Monocytes, macrophages, and neutrophils are... - ANSWER phagocytic
macrophages are also antigen presenting cells
Dendritic cells - ANSWER present in small numbers in blood, skin, and
, mucous membranes of the nose, lungs, and intestines
contact and process antigens, then display on their surface for antigen
presentation
True/False: Dendritic cells come from both the myeloid and lymphoid stem
cell lines - ANSWER True
Macrophages - ANSWER long life
reside in different parts of the body - kidney, liver, lung, under the skin, etc
phagocytic
antigen-presenting
produce cytokines
Macrophages bind directly to pathogen without any other processing which
makes it quicker not to have to wait for communication from other cells.
How do they do this? (6 receptors) - ANSWER 1. LPS receptors - recognize
bacterial LPS
2. Toll-Like Receptors - recognize pathogen surface molecules - cell wall,
membrane, teichoic acid
3. Mannose receptors - recognize mannose on bacterial surface
4. Scavenger receptors - look for any sign of bacteria - directly attach
5. FC receptors (for antibodies)
6. Complement receptors
Antigen presenting cells (APCs) - ANSWER dendritic cells, macrophages, B
cells
