Janeways Immunology - Chapter 10 With
Complete Questions And Answers
Class switching in thymus-dependent antibody responses requires expression of ____
____ by helper T cells and is directed by _____ - CORRECT ANSWERS-1. CD40
Ligand
2. cytokines
Hyper IgM syndrome - CORRECT ANSWERS-High levels of IgM due to reduced class
switching due to genetic deficiency of CD40 ligand
Naive B-cells express what cell surface antibodies? - CORRECT ANSWERS-IgM and
IgD (IgM is the first)
Different cytokines induce switching to different ____ classes - CORRECT ANSWERS-
antibody
Germinal center B cells are inherently prone to dying. What signals must they receive to
survive? - CORRECT ANSWERS-Ligation of CD40 with CD40L and contact with T-
follicular helper cells
Surviving germinal center B cells differentiate into 2 types of cells. Name them. -
CORRECT ANSWERS-Either plasma cells or memory cells
B-cells to plasma cells (process) - CORRECT ANSWERS-- stop differentiation and
transcription factors
- Stop the expression of CXCR5
- Express chemokines that drag the plasma cells towards the medullary cords, lamina
propria or the bone marrow (can live a long time in the bone marrow)
Thymus-independent antigens - CORRECT ANSWERS-Do not require T-cell help to
induce B-cell response
Thymus-independent antigens (2 classes) - CORRECT ANSWERS-TI-1 antigens (do
not lead to B memory cell formation)
TI-2 antigens
TI-1 antigens in high concentration - CORRECT ANSWERS--non-specific antibody
response (without going via BCR)
- activate B-cells via POLYCLONAL ACTIVATION
- aka B-cell mitogen (induces mitosis) td LPS
, TI-1 antigens in low concentration - CORRECT ANSWERS-- specific antibody response
(via BCR) - signal 2
TI-2 antigens - CORRECT ANSWERS-- Can only activate mature b-cells (td B1 cells
and marginal zone b-cells)
- cannot give signal 2
- can signal b-cells to produce IgM antibody
- Important in defence against pathogens with polysaccharide surface
Ung börn aðallega með óþroskaðar B
frumur => mynda illa mótefni gegn
______ - CORRECT ANSWERS-Fjölsykrum
IgM antibody - CORRECT ANSWERS-- High concentration in the serum
- Large in size - pentamers
- Activates the COMPLIMENT SYSTEM
- The first antibody to be produced in an infection
- Low AFFINITY
IgG antibody - CORRECT ANSWERS-- Main antigen in blood and extracellular fluid
- Monomer
- Travels across the placenta
- FcRn transports IgG from the mother to the fetes and across the intestinal wall
IgA antibody - CORRECT ANSWERS-- Main antibody in the mucous lining
- Dimeric
- Present in bowel, airways, lactating breast, exocrine (eg saliva and tear glands)
- Breast milk containing IgA protects babies intestinal lining
- Also found in serum
IgA travels over the mucosal lining via what receptor? - CORRECT ANSWERS-Poly IgR
Antibodies involved in neutralization - CORRECT ANSWERS-IgA - mucosal lining
surface
IgG - body cavities
Neutralise bacteria, viruses and toxins
Antibody:antigen complexes activate the classical pathway of complement by binding to
____ - CORRECT ANSWERS-C1q
Complement receptors are important in the removal of _________ from the circulation -
CORRECT ANSWERS-1. immune complexes
FcR (Fc receptors) - CORRECT ANSWERS-Family of cell surface molecules that bind
the Fc portion of the immunogloblin
Complete Questions And Answers
Class switching in thymus-dependent antibody responses requires expression of ____
____ by helper T cells and is directed by _____ - CORRECT ANSWERS-1. CD40
Ligand
2. cytokines
Hyper IgM syndrome - CORRECT ANSWERS-High levels of IgM due to reduced class
switching due to genetic deficiency of CD40 ligand
Naive B-cells express what cell surface antibodies? - CORRECT ANSWERS-IgM and
IgD (IgM is the first)
Different cytokines induce switching to different ____ classes - CORRECT ANSWERS-
antibody
Germinal center B cells are inherently prone to dying. What signals must they receive to
survive? - CORRECT ANSWERS-Ligation of CD40 with CD40L and contact with T-
follicular helper cells
Surviving germinal center B cells differentiate into 2 types of cells. Name them. -
CORRECT ANSWERS-Either plasma cells or memory cells
B-cells to plasma cells (process) - CORRECT ANSWERS-- stop differentiation and
transcription factors
- Stop the expression of CXCR5
- Express chemokines that drag the plasma cells towards the medullary cords, lamina
propria or the bone marrow (can live a long time in the bone marrow)
Thymus-independent antigens - CORRECT ANSWERS-Do not require T-cell help to
induce B-cell response
Thymus-independent antigens (2 classes) - CORRECT ANSWERS-TI-1 antigens (do
not lead to B memory cell formation)
TI-2 antigens
TI-1 antigens in high concentration - CORRECT ANSWERS--non-specific antibody
response (without going via BCR)
- activate B-cells via POLYCLONAL ACTIVATION
- aka B-cell mitogen (induces mitosis) td LPS
, TI-1 antigens in low concentration - CORRECT ANSWERS-- specific antibody response
(via BCR) - signal 2
TI-2 antigens - CORRECT ANSWERS-- Can only activate mature b-cells (td B1 cells
and marginal zone b-cells)
- cannot give signal 2
- can signal b-cells to produce IgM antibody
- Important in defence against pathogens with polysaccharide surface
Ung börn aðallega með óþroskaðar B
frumur => mynda illa mótefni gegn
______ - CORRECT ANSWERS-Fjölsykrum
IgM antibody - CORRECT ANSWERS-- High concentration in the serum
- Large in size - pentamers
- Activates the COMPLIMENT SYSTEM
- The first antibody to be produced in an infection
- Low AFFINITY
IgG antibody - CORRECT ANSWERS-- Main antigen in blood and extracellular fluid
- Monomer
- Travels across the placenta
- FcRn transports IgG from the mother to the fetes and across the intestinal wall
IgA antibody - CORRECT ANSWERS-- Main antibody in the mucous lining
- Dimeric
- Present in bowel, airways, lactating breast, exocrine (eg saliva and tear glands)
- Breast milk containing IgA protects babies intestinal lining
- Also found in serum
IgA travels over the mucosal lining via what receptor? - CORRECT ANSWERS-Poly IgR
Antibodies involved in neutralization - CORRECT ANSWERS-IgA - mucosal lining
surface
IgG - body cavities
Neutralise bacteria, viruses and toxins
Antibody:antigen complexes activate the classical pathway of complement by binding to
____ - CORRECT ANSWERS-C1q
Complement receptors are important in the removal of _________ from the circulation -
CORRECT ANSWERS-1. immune complexes
FcR (Fc receptors) - CORRECT ANSWERS-Family of cell surface molecules that bind
the Fc portion of the immunogloblin
