PNN Day 1 - Blood Thinners Questions And Answers Already Graded A+

What oral anticoagulants do not require bridging with parenteral anticoagulation? - ️️Rivaroxaban and Apixaban. Otherwise bridge with parenteral anticoagulant for 5-10 days. What is the treatment dose for heparin? - ️️5000-10,000 unit bolus, then 1,000 units/hr; titrate based on aPTT. OR Load with 80 units/kg, then 18 units/kg/hr; titrate based on aPTT How often do we check aPTT for heparin? - ️️every 6 hours Heparin titration -- if aPTT is < 35 seconds? - ️️80u/kg bolus, then increase by 4u/kg/hr Heparin titration -- if aPTT is 35-45 seconds? - ️️40u/kg bolus, then increase by 2u/kg/hr heparin titration -- if aPTT is 46-70 seconds? - ️️no changee heparin titration -- if aPTT is 71-90 seconds? - ️️decrease infusion rate by 2u/kg/hr Heparin titration -- if aPTT is >90 seconds? - ️️hold infusion for 1 hr, then decrease infusion rate by 3u/kg/hr Heparin prophylaxis does not impact PTT (the dose is too small) Therapeutic range for PTT: 45-70 seconds What does INR measure? - ️️It's standardized PT -- used to measure efficacy of warfarin. What is the INR goal for a patient with a-fib/flutter? - ️️INR 2-3 What is the INR goal for a patient undergoing elective cardioversion of a-fib? - ️️INR 2-3 What is the INR goal for someone with a PE or DVT? - ️️INR 2-3What is the INR goal for a patient with a mechanical prosthetic heart valve? - ️️INR 2.5 - 3.5 What lab value is used to measure efficacy of heparin? - ️️aPTT or PTT What pathway does heparin exert its effect? - ️️Intrinsic pathway Which drug blocks the extrinsic pathway? - ️️Warfarin