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NAPLEX 2024 QUESTIONS ANDCORRECTANSWERS LATEST UPLOAD2024/2025BESTEXAM SOLUTION RATED A+ FORSUCCESS

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NAPLEX 2024 QUESTIONS ANDCORRECTANSWERS LATEST UPLOAD2024/2025BESTEXAM SOLUTION RATED A+ FORSUCCESSKey drugs that can cause hypothyroidism - CORRECT ANSWERS "I TALC" Interferons Tyrosine Kinase Inhibitors Amiodarone Lithium Carbamazepine Conditions: Hashimoto's disease Levothyroxine IV:PO - CORRECT ANSWERS 0.75:1 (IV:PO) Full replacement dose levothyroxine - CORRECT ANSWERS 1.6 mcg/kg/day (IBW) If known CAD: start with 12.5-25 mcg daily Levothyroxine tablet colors - CORRECT ANSWERS Orangutans Will Vomit On YouRight Before They Become Large Proud Giants 25 Orange 50 White (no dye) 75 Violet 88 Olive ONLYSTUDENT STORE 2024/2025 ALL THEBESTONLYSTUDENT STORE 2 DO NOT COPY 100 Yellow 112 Rose 125 Brown 137 Turquoise 150 Blue 175 Lilac 200 Pink 300 Green Drug induced causes of hyperthyroidism - CORRECT ANSWERS Iodine Amiodarone Interferons Radiographic contrast media treatment for thyroid storm - CORRECT ANSWERS Antithyroid (PTU preferred- give1hour before iodide) Inorganic iodide therapy (SSKI or Lugol's) Beta Blocker (Propranolol) Systemic steroid (dexamethasone) Aggressive cooling (APAP, cooling blankets, supportive treatments) Hyperthyroid in pregnancy - CORRECT ANSWERS Hyperthyroidism during pregnancyshould be treated with propylthiouracil (PTU) during the first trimester then methimazoleduring the second and third trimesters. Although methimazole is a teratogen, the teratogenic ONLYSTUDENT STORE 2024/2025 ALL THEBESTONLYSTUDENT STORE 3 DO NOT COPY effects are less during the second and third trimesters, and PTU can cause liver failure, which is why it is substituted out. Cushing's syndrome - CORRECT ANSWERS Adrenal gland produces too much cortisol or exogenous steroids are taken in doses higher than normal amounts of endogenous cortisol Addison's disease - CORRECT ANSWERS a condition that occurs when the adrenal glands do not produce enough cortisol; Addisonian crisis (volume depletion and hypotension, which can be fatal) Steroids: least to most potent - CORRECT ANSWERS (Cute Hot Pharmacists andPhysicians Marry Together & Deliver Babies) o Cortisone (25 mg): short acting o Hydrocortisone (20 mg): short acting o Prednisone (5 mg): intermediate acting o Prednisolone (5 mg): intermediate acting o Methylprednisolone (4 mg): intermediate acting o Triamcinolone (4 mg): intermediate acting o Dexamethasone (0.75 mg): long acting, highest potency o Betamethasone (0.6 mg): long acting, highest potency Immunosuppression from steroids - CORRECT ANSWERS A patient is immunosuppressedwhen using /= 2mg/kg/day or /= 20mg/day of prednisone or prednisone equivalent for 2weeks Immunosuppressed patients cannot receive live vaccines and have a high risk of infection ONLYSTUDENT STORE 2024/2025 ALL THEBESTONLYSTUDENT STORE 4 DO NOT COPY steroid will need to be slowly tapered off: reduce 10-20% every few days (tapers canlast 7- 14 days, longer or shorter) Traditional DMARDs (disease modifying anti-rheumatic drugs) - CORRECT ANSWERSMTX (Trexall): first line in RA Hydroxychloroquine (Plaquenil) Sulfasalazine Leflunomide (Arava) Traditional DMARDs (disease modifying anti-rheumatic drugs): MTX - CORRECTANSWERS MTX (Trexall): first line in RA - irreversibly binds and inhibit dihydrofolate reductase, inhibiting folate - 7.5 to 20 mg once weekly - hepatotoxicity (avoid alcohol), myelosuppression, mucosistis/stomatitis, teratogenic - monitor: CBC, LFTs, chest X-ray, hep B/C - folate replacement - renal elimination is decreased by aspirin/NSAIDs Traditional DMARDs (disease modifying anti-rheumatic drugs): hydroxychloroquine - CORRECT ANSWERS Hydroxychloroquine (Plaquenil) - Irreversible retinopathy - take with food or milk - alternative to MTX in liver disease ONLYSTUDENT STORE 2024/2025 ALL THEBESTONLYSTUDENT STORE 5 DO NOT COPY Traditional DMARDs (disease modifying anti-rheumatic drugs): Sulfasalazine - CORRECTANSWERS Sulfasalazine - CI in sulfa/salicylate allergy - can cause yellow-orange coloration of skin/urine - caution in patients with G6PD deficiency Traditional DMARDs (disease modifying anti-rheumatic drugs): Leflunomide - CORRECTANSWERS Leflunomide (Arava) - inhibits pyrimidine sy

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ONLYSTUDENT STORE 2024/2025 ALL THE BEST



NAPLEX 2024 QUESTIONS AND CORRECT
ANSWERS LATEST UPLOAD 2024/2025 BEST
EXAM SOLUTION RATED A+ FOR SUCCESS
Key drugs that can cause hypothyroidism - CORRECT ANSWERS "I TALC"

Interferons

Tyrosine Kinase Inhibitors

Amiodarone

Lithium

Carbamazepine

Conditions: Hashimoto's disease




Levothyroxine IV:PO - CORRECT ANSWERS 0.75:1 (IV:PO)




Full replacement dose levothyroxine - CORRECT ANSWERS 1.6 mcg/kg/day (IBW)

If known CAD: start with 12.5-25 mcg daily




Levothyroxine tablet colors - CORRECT ANSWERS Orangutans Will Vomit On You Right
Before They Become Large Proud Giants




25 Orange

50 White (no dye)

75 Violet

88 Olive




ONLYSTUDENT STORE 1 DO NOT COPY

,ONLYSTUDENT STORE 2024/2025 ALL THE BEST


100 Yellow

112 Rose

125 Brown

137 Turquoise

150 Blue

175 Lilac

200 Pink

300 Green




Drug induced causes of hyperthyroidism - CORRECT ANSWERS Iodine

Amiodarone

Interferons

Radiographic contrast media




treatment for thyroid storm - CORRECT ANSWERS Antithyroid (PTU preferred- give 1 hour
before iodide)

Inorganic iodide therapy (SSKI or Lugol's)

Beta Blocker (Propranolol)

Systemic steroid (dexamethasone)

Aggressive cooling (APAP, cooling blankets, supportive treatments)




Hyperthyroid in pregnancy - CORRECT ANSWERS Hyperthyroidism during pregnancy
should be treated with propylthiouracil (PTU) during the first trimester then methimazole
during the second and third trimesters. Although methimazole is a teratogen, the teratogenic




ONLYSTUDENT STORE 2 DO NOT COPY

,ONLYSTUDENT STORE 2024/2025 ALL THE BEST


effects are less during the second and third trimesters, and PTU can cause liver failure,
which is why it is substituted out.




Cushing's syndrome - CORRECT ANSWERS Adrenal gland produces too much cortisol or
exogenous steroids are taken in doses higher than normal amounts of endogenous cortisol




Addison's disease - CORRECT ANSWERS a condition that occurs when the adrenal
glands do not produce enough cortisol; Addisonian crisis (volume depletion and hypotension,
which can be fatal)




Steroids: least to most potent - CORRECT ANSWERS (Cute Hot Pharmacists and
Physicians Marry Together & Deliver Babies)

o Cortisone (25 mg): short acting

o Hydrocortisone (20 mg): short acting

o Prednisone (5 mg): intermediate acting

o Prednisolone (5 mg): intermediate acting

o Methylprednisolone (4 mg): intermediate acting

o Triamcinolone (4 mg): intermediate acting

o Dexamethasone (0.75 mg): long acting, highest potency

o Betamethasone (0.6 mg): long acting, highest potency




Immunosuppression from steroids - CORRECT ANSWERS A patient is immunosuppressed
when using >/= 2mg/kg/day or >/= 20mg/day of prednisone or prednisone equivalent for >2
weeks




Immunosuppressed patients cannot receive live vaccines and have a high risk of infection



ONLYSTUDENT STORE 3 DO NOT COPY

, ONLYSTUDENT STORE 2024/2025 ALL THE BEST




steroid will need to be slowly tapered off: reduce 10-20% every few days (tapers can last 7-
14 days, longer or shorter)




Traditional DMARDs (disease modifying anti-rheumatic drugs) - CORRECT ANSWERS
MTX (Trexall): first line in RA

Hydroxychloroquine (Plaquenil)

Sulfasalazine

Leflunomide (Arava)




Traditional DMARDs (disease modifying anti-rheumatic drugs): MTX - CORRECT
ANSWERS MTX (Trexall): first line in RA

- irreversibly binds and inhibit dihydrofolate reductase, inhibiting folate

- 7.5 to 20 mg once weekly

- hepatotoxicity (avoid alcohol), myelosuppression, mucosistis/stomatitis, teratogenic

- monitor: CBC, LFTs, chest X-ray, hep B/C

- folate replacement

- renal elimination is decreased by aspirin/NSAIDs




Traditional DMARDs (disease modifying anti-rheumatic drugs): hydroxychloroquine -
CORRECT ANSWERS Hydroxychloroquine (Plaquenil)

- Irreversible retinopathy

- take with food or milk

- alternative to MTX in liver disease




ONLYSTUDENT STORE 4 DO NOT COPY

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