UNE Biochemistry Unit 2 Test
3, 2, 4, 1 - Answers -Order the following statements to illustrate the correct cascade of
events that occurs after ligand binding of G-protein coupled receptor (heptahelical
receptor).
1. Degradation of cAMP by phosphodiesterase
2. Dissociation of Gβ and Gγ subunits
3. G protein exchanges GDP for GTP in the G-αs subunit
4. Activation of adenylyl cyclase (effector E) to generate cAMP
Nuclear localization signal - Answers -A suspected mutation in the cortisol receptor is
discovered. Cortisol can still bind its receptor but the dimerized complex remains in the
cytosol. Based on this description which region on the receptor is likely impacted?
Free fatty acids - Answers -What is the primary oxidized fuel for skeletal muscle in the
fasted state?
Glucagon - Answers -Caffeine is a natural inhibitor of phosphodiesterase. If you were to
consume a large amount of coffee you would likely see a prolonged response to which
of the following stimulants or hormones?
Protein Kinase B - Answers -In the event that PI-3 kinase is not activated downstream
of insulin, which of the following proteins would not be able to dock to the membrane?
Gluconeogenesis - Answers -A patient is found to have a rare disease in which the
secretory function of the α-cells of the pancreas is impaired. As a consequence,
glucagon cannot be secreted. Direct stimulation of which of the following pathways in
liver will be impaired?
Phosphodiesterase - Answers -What enzymes is responsible for the degradation of
cAMP?
VLDL particles - Answers -Insulin stimulates fatty acid synthesis in the liver. These fatty
acids are transported to the adipose tissue as which of the following?
Phosphofructokinase-1 (PFK1) - Answers -After a meal, fructose 2,6-bisphosphate
levels are elevated. This compound will allosterically activate which of the following
glycolytic enzymes?
3, 2, 4, 1 - Answers -Order the following statements to illustrate the correct cascade of
events that occurs after ligand binding of G-protein coupled receptor (heptahelical
receptor).
1. Degradation of cAMP by phosphodiesterase
2. Dissociation of Gβ and Gγ subunits
3. G protein exchanges GDP for GTP in the G-αs subunit
4. Activation of adenylyl cyclase (effector E) to generate cAMP
Nuclear localization signal - Answers -A suspected mutation in the cortisol receptor is
discovered. Cortisol can still bind its receptor but the dimerized complex remains in the
cytosol. Based on this description which region on the receptor is likely impacted?
Free fatty acids - Answers -What is the primary oxidized fuel for skeletal muscle in the
fasted state?
Glucagon - Answers -Caffeine is a natural inhibitor of phosphodiesterase. If you were to
consume a large amount of coffee you would likely see a prolonged response to which
of the following stimulants or hormones?
Protein Kinase B - Answers -In the event that PI-3 kinase is not activated downstream
of insulin, which of the following proteins would not be able to dock to the membrane?
Gluconeogenesis - Answers -A patient is found to have a rare disease in which the
secretory function of the α-cells of the pancreas is impaired. As a consequence,
glucagon cannot be secreted. Direct stimulation of which of the following pathways in
liver will be impaired?
Phosphodiesterase - Answers -What enzymes is responsible for the degradation of
cAMP?
VLDL particles - Answers -Insulin stimulates fatty acid synthesis in the liver. These fatty
acids are transported to the adipose tissue as which of the following?
Phosphofructokinase-1 (PFK1) - Answers -After a meal, fructose 2,6-bisphosphate
levels are elevated. This compound will allosterically activate which of the following
glycolytic enzymes?
