Kaplan and Sadock's Chapter 13 & 26
from Study Guide Questions and Correct
Answers Graded A+
13.1. Which of the following statements about the dopamine hypothesis of schizophrenia is true?
A. Dysregulation of dopaminergic neurotransmission is caused by postsynaptic sensitivity.
B. Dopamine release caused by amphetamine challenge is higher during remission.
C. Higher amphetamine-provoked dopamine release predicts worsening of psychotic symptoms.
D. Overactivity of dopamine in the subcortical basal ganglia contributes to negative symptoms.
E. There is a lower occupancy of D2/3 receptors in relapsed patients. - Answer: C. Higher amphetamine-
provoked dopamine release predicts worsening of psychotic symptoms.
13.2. True statements about hypothesized neurobiological models of schizophrenia include
A. Genes function in part by increasing vulnerability to environmental factors.
B. Environmental factors increase risk by producing subtle brain damage.
C. The apparent lack of gliosis in postmortem studies implicates in utero factors.
D. As the prefrontal cortex matures, behavioral and cognitive sequelae of subtle structural deficits
become manifest.
E. All of the above - Answer: E. All of the above
13.3. With regard to the ventricular size in schizophrenia, which of the following statements is true?
A. Patients with schizophrenia invariably demonstrate significant enlargement of the fourth ventricle
only.
B. Ventricular enlargement is a pathognomonic finding in schizophrenia.
C. Ventricular changes in schizophrenia are likely to be specific for the pathophysiological processes
underlying this disorder.
D. All of the above
E. None of the above - Answer: E. None of the above
,13.4. All of the following lead to an increased risk of schizophrenia except
A. having a deviant course of personality maturation and development
B. having previously attempted suicide
C. having a schizophrenic family member
D. having a history of temporal lobe epilepsy
E. having low levels of monoamine oxidase, type B, in blood platelets - Answer: B. having previously
attempted suicide
13.5. True statements about violence and schizophrenia include all of the following except
A. Violence in a hospital setting can result from undiagnosed neuroleptic-induced acute akathisia.
B. Patients with schizophrenia are more violent as a group than the general population.
C. It is more difficult to prevent most schizophrenic homicides compared with the general population.
D. Patients with disorganized schizophrenia are at much greater risk to commit violence than those with
paranoid schizophrenia.
E. Command hallucinations do not appear to play a particularly important role in violence. - Answer: D.
Patients with disorganized schizophrenia are at much greater risk to commit violence than those with
paranoid schizophrenia.
13.6. Which of the following statements best describes a characteristic of the epidemiology of
schizophrenia?
A. Female patients with schizophrenia are more likely to commit suicide than are male patients.
B. In the northern hemisphere, schizophrenia occurs more often among people born from July to
September than in those born in the other months.
C. Reproduction rates among people with schizophrenia are typically higher than those among the
general population.
D. Patients with schizophrenia occupy about 50 percent of all hospital beds.
E. Some regions of the world have an unusually high prevalence of schizophrenia. - Answer: E. Some
regions of the world have an unusually high prevalence of schizophrenia.
13.7. True statements about eye movement dysfunction in schizophrenia include
A. Abnormal eye movements occur more often in patients with schizophrenia compared with control
subjects.
, B. Eye movement dysfunction is associated with a frontal lobe pathology.
C. Eye movement dysfunction is independent of drug treatment.
D. Eye movement dysfunction is seen in first degree probands.
E. All of the above - Answer: E. All of the above
13.8. In general, pooled studies show concordance rates for schizophrenia in monozygotic twins of
A. 0.1 percent
B. 5 percent
C. 25 percent
D. 40 percent
E. 50 percent - Answer: E. 50 percent
13.9. A schizophrenic patient who states that he feels his brain burning is most likely experiencing a
A. cenesthetic hallucination
B. delusional feeling
C. gustatory hallucination
D. haptic hallucination
E. hypnopompic hallucination - Answer: A. cenesthetic hallucination
13.10. Childhood schizophrenia
A. tends to have a chronic course
B. tends to have a better prognosis that adult schizophrenia
C. is not diagnosed using the same symptoms as are used for adult schizophrenia
D. tends to have an abrupt onset
E. all of the above - Answer: A. tends to have a chronic course
13.11. Late-onset schizophrenia
A. is more common in men
B. is associated with a preponderance of paranoid symptoms
from Study Guide Questions and Correct
Answers Graded A+
13.1. Which of the following statements about the dopamine hypothesis of schizophrenia is true?
A. Dysregulation of dopaminergic neurotransmission is caused by postsynaptic sensitivity.
B. Dopamine release caused by amphetamine challenge is higher during remission.
C. Higher amphetamine-provoked dopamine release predicts worsening of psychotic symptoms.
D. Overactivity of dopamine in the subcortical basal ganglia contributes to negative symptoms.
E. There is a lower occupancy of D2/3 receptors in relapsed patients. - Answer: C. Higher amphetamine-
provoked dopamine release predicts worsening of psychotic symptoms.
13.2. True statements about hypothesized neurobiological models of schizophrenia include
A. Genes function in part by increasing vulnerability to environmental factors.
B. Environmental factors increase risk by producing subtle brain damage.
C. The apparent lack of gliosis in postmortem studies implicates in utero factors.
D. As the prefrontal cortex matures, behavioral and cognitive sequelae of subtle structural deficits
become manifest.
E. All of the above - Answer: E. All of the above
13.3. With regard to the ventricular size in schizophrenia, which of the following statements is true?
A. Patients with schizophrenia invariably demonstrate significant enlargement of the fourth ventricle
only.
B. Ventricular enlargement is a pathognomonic finding in schizophrenia.
C. Ventricular changes in schizophrenia are likely to be specific for the pathophysiological processes
underlying this disorder.
D. All of the above
E. None of the above - Answer: E. None of the above
,13.4. All of the following lead to an increased risk of schizophrenia except
A. having a deviant course of personality maturation and development
B. having previously attempted suicide
C. having a schizophrenic family member
D. having a history of temporal lobe epilepsy
E. having low levels of monoamine oxidase, type B, in blood platelets - Answer: B. having previously
attempted suicide
13.5. True statements about violence and schizophrenia include all of the following except
A. Violence in a hospital setting can result from undiagnosed neuroleptic-induced acute akathisia.
B. Patients with schizophrenia are more violent as a group than the general population.
C. It is more difficult to prevent most schizophrenic homicides compared with the general population.
D. Patients with disorganized schizophrenia are at much greater risk to commit violence than those with
paranoid schizophrenia.
E. Command hallucinations do not appear to play a particularly important role in violence. - Answer: D.
Patients with disorganized schizophrenia are at much greater risk to commit violence than those with
paranoid schizophrenia.
13.6. Which of the following statements best describes a characteristic of the epidemiology of
schizophrenia?
A. Female patients with schizophrenia are more likely to commit suicide than are male patients.
B. In the northern hemisphere, schizophrenia occurs more often among people born from July to
September than in those born in the other months.
C. Reproduction rates among people with schizophrenia are typically higher than those among the
general population.
D. Patients with schizophrenia occupy about 50 percent of all hospital beds.
E. Some regions of the world have an unusually high prevalence of schizophrenia. - Answer: E. Some
regions of the world have an unusually high prevalence of schizophrenia.
13.7. True statements about eye movement dysfunction in schizophrenia include
A. Abnormal eye movements occur more often in patients with schizophrenia compared with control
subjects.
, B. Eye movement dysfunction is associated with a frontal lobe pathology.
C. Eye movement dysfunction is independent of drug treatment.
D. Eye movement dysfunction is seen in first degree probands.
E. All of the above - Answer: E. All of the above
13.8. In general, pooled studies show concordance rates for schizophrenia in monozygotic twins of
A. 0.1 percent
B. 5 percent
C. 25 percent
D. 40 percent
E. 50 percent - Answer: E. 50 percent
13.9. A schizophrenic patient who states that he feels his brain burning is most likely experiencing a
A. cenesthetic hallucination
B. delusional feeling
C. gustatory hallucination
D. haptic hallucination
E. hypnopompic hallucination - Answer: A. cenesthetic hallucination
13.10. Childhood schizophrenia
A. tends to have a chronic course
B. tends to have a better prognosis that adult schizophrenia
C. is not diagnosed using the same symptoms as are used for adult schizophrenia
D. tends to have an abrupt onset
E. all of the above - Answer: A. tends to have a chronic course
13.11. Late-onset schizophrenia
A. is more common in men
B. is associated with a preponderance of paranoid symptoms
