Maryville Pharm NURS 615 Exam 1
what the drug does to the body - Answer-Pharmacodynamics
what the body does to the drug (absorption, distribution, metabolism, excretion) - Answer-
pharmacokinetics
how is the drug entered into the body? - Answer-absorption
which substance is most likely to be absorbed in the intestines rather than in the stomach? - Answer-
sodium bicarb
what happens to drugs if there is kidney insufficency - Answer-they are not eliminated properly. There
can be a build up which can cause a stronger effect, longer effect, and toxicity
what does absorption of a drug depend on? - Answer-membrane penetration, lipid solubility, and
ionization (which depends on pH)
drugs that are ionized are ____ - Answer-hydrophilic
drugs that are unionized are ____ - Answer-lipophilic
, ___philic drugs absorb easily across membranes - Answer-lipophilic
membrane penetration, how things diffuse across - Answer-distribution
Lipophilic drugs typically go through membranes _____ - Answer-passively
drugs that are protein bound require a certain amount of ___ in the blood - Answer-albumin
drugs are not ___ when they are bound to proteins - Answer-active
only unbound/free drugs can ___ - Answer-act
what is first pass effect - Answer-when drugs are taken orally they must first pass through the liver and
then be metabolized; whatever is left after metabolism is sent on to circulation
Not enough albumin or impaired kidney/liver function can cause? - Answer-drug toxicity
what does distribution depend on - Answer-the type of tissue the drug needs to distribute to for its
actions
these kinds of drugs have a very low volume of distribution because they tend to roam freely in the
circulation and are cleared by the kidneys - Answer-hydrophilic
these drugs have a high volume of distribution are a cleared by the liver with high intracellular and
tissue penetration - Answer-lipophilic
___ has an effect on lipophilic drugs so they should be given using total body weight - Answer-obesity
what the drug does to the body - Answer-Pharmacodynamics
what the body does to the drug (absorption, distribution, metabolism, excretion) - Answer-
pharmacokinetics
how is the drug entered into the body? - Answer-absorption
which substance is most likely to be absorbed in the intestines rather than in the stomach? - Answer-
sodium bicarb
what happens to drugs if there is kidney insufficency - Answer-they are not eliminated properly. There
can be a build up which can cause a stronger effect, longer effect, and toxicity
what does absorption of a drug depend on? - Answer-membrane penetration, lipid solubility, and
ionization (which depends on pH)
drugs that are ionized are ____ - Answer-hydrophilic
drugs that are unionized are ____ - Answer-lipophilic
, ___philic drugs absorb easily across membranes - Answer-lipophilic
membrane penetration, how things diffuse across - Answer-distribution
Lipophilic drugs typically go through membranes _____ - Answer-passively
drugs that are protein bound require a certain amount of ___ in the blood - Answer-albumin
drugs are not ___ when they are bound to proteins - Answer-active
only unbound/free drugs can ___ - Answer-act
what is first pass effect - Answer-when drugs are taken orally they must first pass through the liver and
then be metabolized; whatever is left after metabolism is sent on to circulation
Not enough albumin or impaired kidney/liver function can cause? - Answer-drug toxicity
what does distribution depend on - Answer-the type of tissue the drug needs to distribute to for its
actions
these kinds of drugs have a very low volume of distribution because they tend to roam freely in the
circulation and are cleared by the kidneys - Answer-hydrophilic
these drugs have a high volume of distribution are a cleared by the liver with high intracellular and
tissue penetration - Answer-lipophilic
___ has an effect on lipophilic drugs so they should be given using total body weight - Answer-obesity
