NR 50 midterm
Hypersensitivity: Type 1 - Answer--Mediated IgE
-inflammation due to mast cell degranultion
-anaphylactic, asthma, hay fever
treatment: epinephrine
Hypersensitivity: Type 2 - Answer--Cytotoxic reaction: tissue specific
-binds to the antigen ON THE CELL SURFACE
-macrophages are primary effectors cells involved
cause tissue damage or alter function
Hypersensitivity 2 - Answer--Graves Disease (hyperthyroidism) -alters function not destroy
-blood transfusions reaction- transfused erythrocytes are destroyed by agglutination or lysis
-drug allergies
-hemolytic anemia
Hypersensitivity: type 3 - Answer--Not organ specific
,-antibody binds to soluble antigen OUTSIDE THE CELL SURFACE that was released into the blood or
bodily fluids, and the complex is then deposited in the tissues
Hypersensitivity: Type 3 - Answer--rheumatoid arthritis
-Systemic Lupus Erythematosus (SLE)
-Raynaud's
Hives (urticaria) - Answer-Hypersensitivity Type 1
First responders to innate the immune system - Answer-Neutrophils
Allergic contact dermatitis - Answer-Hypersensitivity Type IV
Type 2 cytotoxic hypersensitivity mediated by: - Answer--IgG IgM
-macrophages are primary effort cells
-
Serum Sickness - Answer-type 3 hypersensitivity
Hypersensitivity IV, - Answer--is more of a delayed immune response.
-mediated T-cells attack tissue directly (no antibodies)
Autoimmune - Answer--diseases in which the body makes antibodies directed against its own tissues
-
Primary immunodeficiency - Answer--Genetic; inherited
, -result of single gene defects
-B and T cell deficiencies
secondary immunodeficiency - Answer--acquired
Common cause of secondary immunodeficiency - Answer-Malnutrition
Most patients diagnosed with SLE will have a positive ? - Answer-antinuclear antibody (ANA)
SLE (lupus) - Answer--Facial rash
-vasculitis
- tissue inflammation
Renal disease associated with autoimmunity? - Answer-Glomerulonephritis
Sjogren's syndrome - Answer-Inflammation in salivary and lacrimal glands
SLE - Answer-Autoantibodies and auto-active t-cells against DNA and nucleoprotein
Sjögren's syndrome immune changes: - Answer-Autoantibodies and auto-reactive t-cells against
apoptotic cells
rheumatoid arthritis manifestations: - Answer-Joint inflammation, stiffness, pain, loss of range of
motion
Rheumatoid Arthritis immune changes: - Answer-T-cells and B cells against joint associated antigens
Hypersensitivity: Type 1 - Answer--Mediated IgE
-inflammation due to mast cell degranultion
-anaphylactic, asthma, hay fever
treatment: epinephrine
Hypersensitivity: Type 2 - Answer--Cytotoxic reaction: tissue specific
-binds to the antigen ON THE CELL SURFACE
-macrophages are primary effectors cells involved
cause tissue damage or alter function
Hypersensitivity 2 - Answer--Graves Disease (hyperthyroidism) -alters function not destroy
-blood transfusions reaction- transfused erythrocytes are destroyed by agglutination or lysis
-drug allergies
-hemolytic anemia
Hypersensitivity: type 3 - Answer--Not organ specific
,-antibody binds to soluble antigen OUTSIDE THE CELL SURFACE that was released into the blood or
bodily fluids, and the complex is then deposited in the tissues
Hypersensitivity: Type 3 - Answer--rheumatoid arthritis
-Systemic Lupus Erythematosus (SLE)
-Raynaud's
Hives (urticaria) - Answer-Hypersensitivity Type 1
First responders to innate the immune system - Answer-Neutrophils
Allergic contact dermatitis - Answer-Hypersensitivity Type IV
Type 2 cytotoxic hypersensitivity mediated by: - Answer--IgG IgM
-macrophages are primary effort cells
-
Serum Sickness - Answer-type 3 hypersensitivity
Hypersensitivity IV, - Answer--is more of a delayed immune response.
-mediated T-cells attack tissue directly (no antibodies)
Autoimmune - Answer--diseases in which the body makes antibodies directed against its own tissues
-
Primary immunodeficiency - Answer--Genetic; inherited
, -result of single gene defects
-B and T cell deficiencies
secondary immunodeficiency - Answer--acquired
Common cause of secondary immunodeficiency - Answer-Malnutrition
Most patients diagnosed with SLE will have a positive ? - Answer-antinuclear antibody (ANA)
SLE (lupus) - Answer--Facial rash
-vasculitis
- tissue inflammation
Renal disease associated with autoimmunity? - Answer-Glomerulonephritis
Sjogren's syndrome - Answer-Inflammation in salivary and lacrimal glands
SLE - Answer-Autoantibodies and auto-active t-cells against DNA and nucleoprotein
Sjögren's syndrome immune changes: - Answer-Autoantibodies and auto-reactive t-cells against
apoptotic cells
rheumatoid arthritis manifestations: - Answer-Joint inflammation, stiffness, pain, loss of range of
motion
Rheumatoid Arthritis immune changes: - Answer-T-cells and B cells against joint associated antigens
