MN553 Quiz 2 Exam| Questions and
Answers
Pharmacokinetics - -The study of:
Absorption
Distribution
Metabolism
Excretion
- Absorption is impacted by - -Parenteral administration
Oral administration
Site of administration
Bioavailability
Peak blood levels
- Distribution - -Movement of absorbed drug in bodily fluids throughout
body to target tissues
- Patterns of distribution - -Only in plasma
To all body fluids/homogenously
Specific tissues
Non-homogenous
-Majority
- Increased diffusion equals - -Increased distribution
- How much affinity of the drugs to the tissues is impacted by - -Distribution
- What else impacts distribution - -Blood flow
-High flow
-Low flow
- True or false
, Concentration of drugs increased faster in well perfused organs - -True
- Organs with high blood flow - -Kidney
Heart
Liver
Brain
- Organs with low blood flow - -Skin
Skeletal/bone
- Characteristics of the blood-brain barrier - -Relatively impenetrable
Usually protective
Only lipid soluble drugs can cross
- Characteristics of the placental barrier - -Many drugs can pass
Low molecular weight drugs pass easier
- True or false
Lipid-soluble fats have a low affinity for adipose tissue. - -False
Lipid-soluble fats have a high affinity for adipose tissue.
- What type of blood flow does adipose tissue have - -Low blood flow
- Can drugs have affinity for bone - -Yes
- What drugs have an affinity for bone - -Tetracyclines
- Factors that influence metabolism - -Age
Genetics
Pregnancy
Liver disease
Time of day
Environment
Diet
Alcohol
Drug interactions
Kidney function
- Chemical reactions in the liver that drugs may undergo - -Phase I
Phase II
Answers
Pharmacokinetics - -The study of:
Absorption
Distribution
Metabolism
Excretion
- Absorption is impacted by - -Parenteral administration
Oral administration
Site of administration
Bioavailability
Peak blood levels
- Distribution - -Movement of absorbed drug in bodily fluids throughout
body to target tissues
- Patterns of distribution - -Only in plasma
To all body fluids/homogenously
Specific tissues
Non-homogenous
-Majority
- Increased diffusion equals - -Increased distribution
- How much affinity of the drugs to the tissues is impacted by - -Distribution
- What else impacts distribution - -Blood flow
-High flow
-Low flow
- True or false
, Concentration of drugs increased faster in well perfused organs - -True
- Organs with high blood flow - -Kidney
Heart
Liver
Brain
- Organs with low blood flow - -Skin
Skeletal/bone
- Characteristics of the blood-brain barrier - -Relatively impenetrable
Usually protective
Only lipid soluble drugs can cross
- Characteristics of the placental barrier - -Many drugs can pass
Low molecular weight drugs pass easier
- True or false
Lipid-soluble fats have a low affinity for adipose tissue. - -False
Lipid-soluble fats have a high affinity for adipose tissue.
- What type of blood flow does adipose tissue have - -Low blood flow
- Can drugs have affinity for bone - -Yes
- What drugs have an affinity for bone - -Tetracyclines
- Factors that influence metabolism - -Age
Genetics
Pregnancy
Liver disease
Time of day
Environment
Diet
Alcohol
Drug interactions
Kidney function
- Chemical reactions in the liver that drugs may undergo - -Phase I
Phase II
