Exam 2 NSG 531 Questions and Correct Answers the Latest Update

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Exam 2 NSG 531 Questions and
Correct Answers the Latest Update
Ka


✓ volume needed to get 1 mol free drug when 50% of receptors are occupied (high
associated with low free drug & high protein binding)



Kd


✓ amount of drug needed to occupy 50% of receptors (high is associated with high free
drug & low protein binding)



Log dose response curve


✓ X axis is dosage, Y axis is effect. steeper curves are more dangerous/harder to
control



potency


✓ in log-dose curves. highest on left of the axis, moves to the right as it gets less potent



efficacy


✓ in log-dose curves; highest efficacy is tallest curve and moves down the y axis (down)
as it decrease in efficacy



graded responses


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✓ uses absolute terms (ex. mmHg). steep curve may mean a small change in dosage but
large change in response



quantal responses


✓ y axis is % of responders (% of ppl who respond to therapeutic effect). Ex. seizure
goes away or doesn't



therapeutic index


✓ the ratio between the toxic and therapeutic concentrations of a drug. narrow
therapeutic effect is unsafe (hard to stay out of toxic range)



agonists


✓ activate/stimulate receptor.



full agonist


✓ produces same maximal effect an intrinsic drug



partial agonist


✓ even if all receptors are full, still doesn't reach maximal effect of intrinsic drug



antagonist


✓ blocks or opposes an action



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