CSB601 TEST WITH COMPLETE
SOLUTION
The role of TGA - Answer Part of Department of Health that regulates therapeutic goods
What classify as therapeutic goods - Answer Medicines and blood products, Medical
devices, Biologicals
Difference between AUST R, AUST L and AUST L(A) - Answer AUST R - registered high
risk medicines that requires pre-market assessment
AUST L - contemporary medicines that hasn't been been assessed for efficacy
AUST LA - listed medicines that had to provide proof of
Principles of QUM - Answer Safety
Efficacy
Appropriate
Judicious
What are generic brands of medications - Answer Medication that has been proved to
have the bioavailability of the branded drugs
Problems with Medication - Answer Adverse medicine events
Adverse medicine reactions
Inappropriate selection
Dosing
w/o indication
Interactions
Untreated indications
Pharmacokinetics - Answer what the body does to the drug (ADME)
What is pharmacodynamics? - Answer What the drug does to the body
- intended effect
- side effect
What does ADME stand for in pharmacokinetics? - Answer Absorption: oral, sublingual,
,blood vessel, GIT
Distribution: Blood vessel, Lymphatic vessel, CNS fluid
Metabolism: Liver, Kidney, Lung
Excretion: Kidney
Bioavailability - Answer A measure (%) of the extent of drug absorption from site of
administration and site of action for a given drug and route.
What is half-life of a medication - Answer The time it takes for plasma concentration of a
drug to decrease by half, which determines the dosing frequency
Interactions between Digoxin and potassium-losing diuretics - Answer Increase
arrhythmias, since potassium-losing diuretics can result in potassium depletion
What medication interacts with NSAIDs - Answer - ACE-inhibitors (Decrease effects)
- Diuretics (Decrease effects)
- Sulfonylureas (Increase hypoglycemic effect)
- Lithium (toxicity)
- Digoxin
Key parameters of Pharmacokinetic - Answer - Half Life
- Volume of Distribution
- Bioavailability
- Clearance
Classes of Antidepressants - Answer SSRIs, SNRIs, TCAs, MAOIs
What class of drugs is Phenelzine and Tranylcypromine - Answer MAOIs
Drug class: Fluvoxamine, Sertraline - Answer SSRIs
Interaction: SSRIs/SNRIs with NSAIDs - Answer Increase risk of bleeding
Interaction: SSRIs/SNRIs with Tramadol - Answer Increase risk of Serotonin Syndrome
What are precautions of lithium use in women - Answer - Increase the risk of congenital
heart defects in pregnancy, neonatal neurotoxicity and hypothyroidism
- Lithium concentration in pregnancy
What the triple whammy of the medications - Answer ACE-inhibitors
Diuretics
, NSAIDs
- Causing increased risk in AKI
Interaction between diuretics and ACE inhibitors/ARBs - Answer postural hypotension
What's the symptoms of Serotonin Toxicity - Answer - Increased temperature
- Agitation
- Tremor
- Palpitations
- sweating
- diarrhea
- mania
Drugs that can contribute to serotonin toxicity - Answer Antidepressants
Opioids
St. john's Wort
Illicit drugs
What class of drug does amitriptyline belongs to - Answer TCAs
What class of drugs does clomipramine and imipramine belong to - Answer TCAs
What are some adverse effects of antidepressants - Answer Serotonin:
- Sexual dysfunction, GI effects, Anxiety, Sleep disturbances
Noradrenaline:
- Elevations in blood pressure
TCAs:
- Histamine blockade
- Muscarinic blockade: dry mouth, blurred vision, constipation, drowsiness
- alpha 1 blockade: dizziness and postural hypotension
How long does antidepressants take effect - Answer - 2-3 weeks to start seeing any
difference
- 6+ weeks to full effect
SOLUTION
The role of TGA - Answer Part of Department of Health that regulates therapeutic goods
What classify as therapeutic goods - Answer Medicines and blood products, Medical
devices, Biologicals
Difference between AUST R, AUST L and AUST L(A) - Answer AUST R - registered high
risk medicines that requires pre-market assessment
AUST L - contemporary medicines that hasn't been been assessed for efficacy
AUST LA - listed medicines that had to provide proof of
Principles of QUM - Answer Safety
Efficacy
Appropriate
Judicious
What are generic brands of medications - Answer Medication that has been proved to
have the bioavailability of the branded drugs
Problems with Medication - Answer Adverse medicine events
Adverse medicine reactions
Inappropriate selection
Dosing
w/o indication
Interactions
Untreated indications
Pharmacokinetics - Answer what the body does to the drug (ADME)
What is pharmacodynamics? - Answer What the drug does to the body
- intended effect
- side effect
What does ADME stand for in pharmacokinetics? - Answer Absorption: oral, sublingual,
,blood vessel, GIT
Distribution: Blood vessel, Lymphatic vessel, CNS fluid
Metabolism: Liver, Kidney, Lung
Excretion: Kidney
Bioavailability - Answer A measure (%) of the extent of drug absorption from site of
administration and site of action for a given drug and route.
What is half-life of a medication - Answer The time it takes for plasma concentration of a
drug to decrease by half, which determines the dosing frequency
Interactions between Digoxin and potassium-losing diuretics - Answer Increase
arrhythmias, since potassium-losing diuretics can result in potassium depletion
What medication interacts with NSAIDs - Answer - ACE-inhibitors (Decrease effects)
- Diuretics (Decrease effects)
- Sulfonylureas (Increase hypoglycemic effect)
- Lithium (toxicity)
- Digoxin
Key parameters of Pharmacokinetic - Answer - Half Life
- Volume of Distribution
- Bioavailability
- Clearance
Classes of Antidepressants - Answer SSRIs, SNRIs, TCAs, MAOIs
What class of drugs is Phenelzine and Tranylcypromine - Answer MAOIs
Drug class: Fluvoxamine, Sertraline - Answer SSRIs
Interaction: SSRIs/SNRIs with NSAIDs - Answer Increase risk of bleeding
Interaction: SSRIs/SNRIs with Tramadol - Answer Increase risk of Serotonin Syndrome
What are precautions of lithium use in women - Answer - Increase the risk of congenital
heart defects in pregnancy, neonatal neurotoxicity and hypothyroidism
- Lithium concentration in pregnancy
What the triple whammy of the medications - Answer ACE-inhibitors
Diuretics
, NSAIDs
- Causing increased risk in AKI
Interaction between diuretics and ACE inhibitors/ARBs - Answer postural hypotension
What's the symptoms of Serotonin Toxicity - Answer - Increased temperature
- Agitation
- Tremor
- Palpitations
- sweating
- diarrhea
- mania
Drugs that can contribute to serotonin toxicity - Answer Antidepressants
Opioids
St. john's Wort
Illicit drugs
What class of drug does amitriptyline belongs to - Answer TCAs
What class of drugs does clomipramine and imipramine belong to - Answer TCAs
What are some adverse effects of antidepressants - Answer Serotonin:
- Sexual dysfunction, GI effects, Anxiety, Sleep disturbances
Noradrenaline:
- Elevations in blood pressure
TCAs:
- Histamine blockade
- Muscarinic blockade: dry mouth, blurred vision, constipation, drowsiness
- alpha 1 blockade: dizziness and postural hypotension
How long does antidepressants take effect - Answer - 2-3 weeks to start seeing any
difference
- 6+ weeks to full effect
