Clinical Immunology and Serology: A Laboratory Perspective 4th Edition Test Bank
Chapter 1. Introduction to Immunity and the Immune System
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. Eosinophils are involved in the immune response against:
A. viruses.
B. intracellular bacteria.
C. parasites that cannot be phagocytized.
D. extracellular bacteria.
____ 2. Which of the following are components of both innate and adaptive immune responses?
A. Immunoglobulins
B. T helper cells
C. Macrophages
D. B cells
____ 3. The process by which leukocytes are attracted to a specific area by chemical messengers is called:
A. diapedesis.
B. degranulation.
C. chemotaxis.
D. opsonization.
____ 4. Which of the following is a characteristic of natural killer cells?
A. They mature in the thymus.
B. They are smaller than B and T cells.
C. They are a type of lymphocyte.
D. They are part of the adaptive immune system.
____ 5. Which of the following best describes diapedesis?
A. Movement toward increasing concentrations of a cytokine
B. Attachment of immunoglobulin to target cells
C. Movement through blood vessel walls as cells exit the circulation
D. Engulfment of target cells
____ 6. The most effective phagocytic and antigen-presenting cell is the:
A. neutrophil.
B. monocyte.
C. dendritic cell.
D. macrophage.
____ 7. Which of the following is characteristic of natural immunity?
A. It involves memory.
B. T lymphocytes play a major role.
C. It involves specificity.
D. Mechanisms are always present and fully functional.
Copyright © 2017 F. A. Davis Company
, Clinical Immunology and Serology: A Laboratory Perspective 4th Edition Test Bank
____ 8. All of the following cells are considered part of natural immunity EXCEPT:
A. eosinophils.
B. B lymphocytes.
C. monocytes.
D. neutrophils.
____ 9. Where does the specific immune response to a foreign antigen mainly occur?
A. Lymph nodes
B. Blood
C. Bone marrow
D. Skin
____ 10. Which white cell in the peripheral blood migrates into tissue to become a macrophage?
A. Eosinophil
B. Basophil
C. Neutrophil
D. Monocyte
____ 11. A white blood cell that is 16 to 18 micrometers in diameter, has a horseshoe-shaped nucleus, and is
capable of phagocytosis is a:
A. neutrophil.
B. eosinophil.
C. basophil.
D. monocyte.
____ 12. Pasteur's discovery that older bacterial cultures would not cause disease in chickens but would protect
them from subsequent infection with more virulent strains is an example of:
A. attenuated vaccine.
B. natural immunity.
C. passive immunity.
D. cross-immunity.
____ 13. Antibodies are secreted by:
A. plasma cells.
B. B cells.
C. T cells.
D. dendritic cells.
____ 14. Which of the following is characteristic of mucosal-associated lymphoid tissue?
A. It is one of the primary lymphoid organs.
B. It clears pathogens from the bloodstream.
C. It includes the tonsils and the appendix.
D. It includes the liver and spleen.
____ 15. Acquired (adaptive) immunity can be characterized as:
A. nonspecifically activated.
B. immediately responsive.
C. neutrophil dependent.
D. involving memory.
____ 16. Which of the following is NOT a characteristic of neutrophils?
A. Congregate in the marginating pool in blood vessels
B. Capable of diapedesis
C. Granules that become bright orange with Wright stain
D. Segmented nucleus
____ 17. The function of NK cells is to:
Copyright © 2017 F. A. Davis Company
, Clinical Immunology and Serology: A Laboratory Perspective 4th Edition Test Bank
A. produce antibody.
B. phagocytize bacteria.
C. present antigen to T cells.
D. kill target cells such as tumor and virally infected cells.
____ 18. All of the following are involved in adaptive immunity EXCEPT:
A. memory.
B. lymphocytes.
C. specificity.
D. neutrophils.
____ 19. Which of the following is NOT a characteristic of a lymph node?
A. Filters interstitial fluid draining from tissues
B. Colonized with T and B cells
C. Between 1 and 25 mm in size
D. Considered a primary or central lymphoid organ
____ 20. All of the following are considered part of natural immunity EXCEPT:
A. eosinophils.
B. lymphocytes.
C. acute-phase reactants.
D. neutrophils.
____ 21. Macrophages that migrate to the liver are called:
A. alveolar macrophages.
B. histiocytes.
C. microglial cells.
D. Kupffer cells.
____ 22. Innate immunity can be characterized as:
A. specific.
B. slow to respond.
C. dependent upon neutrophils and macrophages.
D. involving memory.
____ 23. The ability to resist infection through normally present body functions best characterizes:
A. autoimmunity.
B. natural immunity.
C. acquired immunity.
D. alloimmunity.
____ 24. Which type of cell has a diameter between 10 and 15 micrometers, has a multi-lobed nucleus, and
usually comprises more than 50% of circulating leukocytes?
A. Neutrophil
B. Lymphocyte
C. Basophil
D. Monocyte
____ 25. Which of the following is NOT a component or characteristic of natural (innate) immunity?
A. Repeated exposure to a pathogen does not change the response.
B. The response involves acute-phase reactants.
C. The response involves phagocytosis.
D. The response involves antibodies.
____ 26. T cells are mainly concentrated in which region of the lymph nodes?
A. Primary follicles
B. Secondary follicles
Copyright © 2017 F. A. Davis Company
, Clinical Immunology and Serology: A Laboratory Perspective 4th Edition Test Bank
C. Paracortex
D. Medulla
____ 27. A primary site of antigen trapping and presentation to immune cells is the:
A. spleen.
B. thymus.
C. bone marrow.
D. brain.
____ 28. Hematopoietic stem cells are located in:
A. the lymph nodes.
B. the spleen.
C. bone marrow.
D. the thymus.
____ 29. Which of the following is NOT a characteristic or function of the spleen?
A. Removes old red blood cells from the circulation
B. Filters infectious agents and foreign matter from the blood
C. Less than 25 mm in size
D. Is considered a secondary lymphoid organ
____ 30. T cells mature in:
A. bone marrow.
B. the thymus.
C. the lymph nodes.
D. the spleen.
____ 31. Primary lymphoid organs include which of the following?
A. Spleen
B. Tonsils
C. Thymus
D. Lymph nodes
____ 32. B cells that are actively responding to antigen can be found in:
A. peripheral blood.
B. the primary follicles.
C. the germinal centers.
D. bone marrow.
____ 33. Contact with antigen and activation of B cells normally occurs in:
A. peripheral blood.
B. the connective tissue.
C. the thymus.
D. the lymph nodes.
____ 34. Which best describes lymph nodes?
A. They line the interior of small blood vessels.
B. They are concentrated where appendages join the thorax of the body.
C. They are approximately 12 cm in size.
D. They are considered primary or central lymphoid organs.
____ 35. Which of the following is a characteristic of opsonins?
A. They are carbohydrates that stimulate T cells.
B. They are molecules that coat bacteria, making them more susceptible to phagocytosis.
C. They are expressed on the surface of neutrophils.
D. They are produced by NK cells.
____ 36. “Cluster of differentiation” refers to:
Copyright © 2017 F. A. Davis Company
Chapter 1. Introduction to Immunity and the Immune System
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. Eosinophils are involved in the immune response against:
A. viruses.
B. intracellular bacteria.
C. parasites that cannot be phagocytized.
D. extracellular bacteria.
____ 2. Which of the following are components of both innate and adaptive immune responses?
A. Immunoglobulins
B. T helper cells
C. Macrophages
D. B cells
____ 3. The process by which leukocytes are attracted to a specific area by chemical messengers is called:
A. diapedesis.
B. degranulation.
C. chemotaxis.
D. opsonization.
____ 4. Which of the following is a characteristic of natural killer cells?
A. They mature in the thymus.
B. They are smaller than B and T cells.
C. They are a type of lymphocyte.
D. They are part of the adaptive immune system.
____ 5. Which of the following best describes diapedesis?
A. Movement toward increasing concentrations of a cytokine
B. Attachment of immunoglobulin to target cells
C. Movement through blood vessel walls as cells exit the circulation
D. Engulfment of target cells
____ 6. The most effective phagocytic and antigen-presenting cell is the:
A. neutrophil.
B. monocyte.
C. dendritic cell.
D. macrophage.
____ 7. Which of the following is characteristic of natural immunity?
A. It involves memory.
B. T lymphocytes play a major role.
C. It involves specificity.
D. Mechanisms are always present and fully functional.
Copyright © 2017 F. A. Davis Company
, Clinical Immunology and Serology: A Laboratory Perspective 4th Edition Test Bank
____ 8. All of the following cells are considered part of natural immunity EXCEPT:
A. eosinophils.
B. B lymphocytes.
C. monocytes.
D. neutrophils.
____ 9. Where does the specific immune response to a foreign antigen mainly occur?
A. Lymph nodes
B. Blood
C. Bone marrow
D. Skin
____ 10. Which white cell in the peripheral blood migrates into tissue to become a macrophage?
A. Eosinophil
B. Basophil
C. Neutrophil
D. Monocyte
____ 11. A white blood cell that is 16 to 18 micrometers in diameter, has a horseshoe-shaped nucleus, and is
capable of phagocytosis is a:
A. neutrophil.
B. eosinophil.
C. basophil.
D. monocyte.
____ 12. Pasteur's discovery that older bacterial cultures would not cause disease in chickens but would protect
them from subsequent infection with more virulent strains is an example of:
A. attenuated vaccine.
B. natural immunity.
C. passive immunity.
D. cross-immunity.
____ 13. Antibodies are secreted by:
A. plasma cells.
B. B cells.
C. T cells.
D. dendritic cells.
____ 14. Which of the following is characteristic of mucosal-associated lymphoid tissue?
A. It is one of the primary lymphoid organs.
B. It clears pathogens from the bloodstream.
C. It includes the tonsils and the appendix.
D. It includes the liver and spleen.
____ 15. Acquired (adaptive) immunity can be characterized as:
A. nonspecifically activated.
B. immediately responsive.
C. neutrophil dependent.
D. involving memory.
____ 16. Which of the following is NOT a characteristic of neutrophils?
A. Congregate in the marginating pool in blood vessels
B. Capable of diapedesis
C. Granules that become bright orange with Wright stain
D. Segmented nucleus
____ 17. The function of NK cells is to:
Copyright © 2017 F. A. Davis Company
, Clinical Immunology and Serology: A Laboratory Perspective 4th Edition Test Bank
A. produce antibody.
B. phagocytize bacteria.
C. present antigen to T cells.
D. kill target cells such as tumor and virally infected cells.
____ 18. All of the following are involved in adaptive immunity EXCEPT:
A. memory.
B. lymphocytes.
C. specificity.
D. neutrophils.
____ 19. Which of the following is NOT a characteristic of a lymph node?
A. Filters interstitial fluid draining from tissues
B. Colonized with T and B cells
C. Between 1 and 25 mm in size
D. Considered a primary or central lymphoid organ
____ 20. All of the following are considered part of natural immunity EXCEPT:
A. eosinophils.
B. lymphocytes.
C. acute-phase reactants.
D. neutrophils.
____ 21. Macrophages that migrate to the liver are called:
A. alveolar macrophages.
B. histiocytes.
C. microglial cells.
D. Kupffer cells.
____ 22. Innate immunity can be characterized as:
A. specific.
B. slow to respond.
C. dependent upon neutrophils and macrophages.
D. involving memory.
____ 23. The ability to resist infection through normally present body functions best characterizes:
A. autoimmunity.
B. natural immunity.
C. acquired immunity.
D. alloimmunity.
____ 24. Which type of cell has a diameter between 10 and 15 micrometers, has a multi-lobed nucleus, and
usually comprises more than 50% of circulating leukocytes?
A. Neutrophil
B. Lymphocyte
C. Basophil
D. Monocyte
____ 25. Which of the following is NOT a component or characteristic of natural (innate) immunity?
A. Repeated exposure to a pathogen does not change the response.
B. The response involves acute-phase reactants.
C. The response involves phagocytosis.
D. The response involves antibodies.
____ 26. T cells are mainly concentrated in which region of the lymph nodes?
A. Primary follicles
B. Secondary follicles
Copyright © 2017 F. A. Davis Company
, Clinical Immunology and Serology: A Laboratory Perspective 4th Edition Test Bank
C. Paracortex
D. Medulla
____ 27. A primary site of antigen trapping and presentation to immune cells is the:
A. spleen.
B. thymus.
C. bone marrow.
D. brain.
____ 28. Hematopoietic stem cells are located in:
A. the lymph nodes.
B. the spleen.
C. bone marrow.
D. the thymus.
____ 29. Which of the following is NOT a characteristic or function of the spleen?
A. Removes old red blood cells from the circulation
B. Filters infectious agents and foreign matter from the blood
C. Less than 25 mm in size
D. Is considered a secondary lymphoid organ
____ 30. T cells mature in:
A. bone marrow.
B. the thymus.
C. the lymph nodes.
D. the spleen.
____ 31. Primary lymphoid organs include which of the following?
A. Spleen
B. Tonsils
C. Thymus
D. Lymph nodes
____ 32. B cells that are actively responding to antigen can be found in:
A. peripheral blood.
B. the primary follicles.
C. the germinal centers.
D. bone marrow.
____ 33. Contact with antigen and activation of B cells normally occurs in:
A. peripheral blood.
B. the connective tissue.
C. the thymus.
D. the lymph nodes.
____ 34. Which best describes lymph nodes?
A. They line the interior of small blood vessels.
B. They are concentrated where appendages join the thorax of the body.
C. They are approximately 12 cm in size.
D. They are considered primary or central lymphoid organs.
____ 35. Which of the following is a characteristic of opsonins?
A. They are carbohydrates that stimulate T cells.
B. They are molecules that coat bacteria, making them more susceptible to phagocytosis.
C. They are expressed on the surface of neutrophils.
D. They are produced by NK cells.
____ 36. “Cluster of differentiation” refers to:
Copyright © 2017 F. A. Davis Company
