©EMILLECT 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
MBB 322 final Exam Study Guide Solutions
carcinoma - ANSWER✔✔cancers arising from epithelial cells
Leukemias and Lymphomas - ANSWER✔✔cancers arising from hematopoetic cells
Sarcoma - ANSWER✔✔cancer arising from connective tissue or muscle cells
Wee1 - ANSWER✔✔inhibiting kinase that phosphorylates a Cdk1 on two sites.
cdc25 - ANSWER✔✔inhibiting phosphotase (AKA removes inhibiting phosphates)
CAK - ANSWER✔✔Cyclin activating kinase, phosphorylates another site on Cdk 1
FAS - ANSWER✔✔death ligand
RB - ANSWER✔✔a tumour suppressor that binds E2F, suppressing DNA synthesis , the RAS pathway
causes it's release of E2F via Cyclin-Cdk complex that phosphorylates it.
KIR - ANSWER✔✔binds class I MHC, preventing NK cells from killing target cells.
Ubiquitylation - ANSWER✔✔how M-cyclin and S phase cyclin is degraded by proteasome
RB, P53 - ANSWER✔✔Examples of Tumour Suppressors
Page 1/5
, ©EMILLECT 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
P53 - ANSWER✔✔Controls Cell cycle and DNA repair
Retinoblastoma - ANSWER✔✔loss of RB gene causes this cancer
Deletion or Point mutation in coding sequence - ANSWER✔✔hyperactive protein made in normal
amounts
Regulatory mutation - ANSWER✔✔normal protein greatly overproduced
Gene Amplification - ANSWER✔✔normal protein greatly overproduced
Chromosome Rearrangement - ANSWER✔✔can lead to:
1) nearby regulatory DNA sequences causes normal protein to be overproduced
2) fusion to actively transcribed gene produces hyperactive fusion protein
VEGF - ANSWER✔✔causes growth of new capillaries
HIF1a - ANSWER✔✔this induces cells to secrete VEGF
angiogenesis - ANSWER✔✔the growth of new capillaries from pre-existing blood vessels (via endothelial
progenitor cells)
vasculogenesis - ANSWER✔✔occurs during embryogenesis: the denovo formation of angioblasts,
endothelial cells and a primitive vascular network
Page 2/5
FIRST PUBLISH OCTOBER 2024
MBB 322 final Exam Study Guide Solutions
carcinoma - ANSWER✔✔cancers arising from epithelial cells
Leukemias and Lymphomas - ANSWER✔✔cancers arising from hematopoetic cells
Sarcoma - ANSWER✔✔cancer arising from connective tissue or muscle cells
Wee1 - ANSWER✔✔inhibiting kinase that phosphorylates a Cdk1 on two sites.
cdc25 - ANSWER✔✔inhibiting phosphotase (AKA removes inhibiting phosphates)
CAK - ANSWER✔✔Cyclin activating kinase, phosphorylates another site on Cdk 1
FAS - ANSWER✔✔death ligand
RB - ANSWER✔✔a tumour suppressor that binds E2F, suppressing DNA synthesis , the RAS pathway
causes it's release of E2F via Cyclin-Cdk complex that phosphorylates it.
KIR - ANSWER✔✔binds class I MHC, preventing NK cells from killing target cells.
Ubiquitylation - ANSWER✔✔how M-cyclin and S phase cyclin is degraded by proteasome
RB, P53 - ANSWER✔✔Examples of Tumour Suppressors
Page 1/5
, ©EMILLECT 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
P53 - ANSWER✔✔Controls Cell cycle and DNA repair
Retinoblastoma - ANSWER✔✔loss of RB gene causes this cancer
Deletion or Point mutation in coding sequence - ANSWER✔✔hyperactive protein made in normal
amounts
Regulatory mutation - ANSWER✔✔normal protein greatly overproduced
Gene Amplification - ANSWER✔✔normal protein greatly overproduced
Chromosome Rearrangement - ANSWER✔✔can lead to:
1) nearby regulatory DNA sequences causes normal protein to be overproduced
2) fusion to actively transcribed gene produces hyperactive fusion protein
VEGF - ANSWER✔✔causes growth of new capillaries
HIF1a - ANSWER✔✔this induces cells to secrete VEGF
angiogenesis - ANSWER✔✔the growth of new capillaries from pre-existing blood vessels (via endothelial
progenitor cells)
vasculogenesis - ANSWER✔✔occurs during embryogenesis: the denovo formation of angioblasts,
endothelial cells and a primitive vascular network
Page 2/5
