NGR 6172 Dementia with 100%
correct answers (latest update)
What factors are thought to be somewhat protective for Alzheimer's-type
dementia (AD)? - answer caffeine, exercise, diet (high in fish, fruits,
vegetables, antioxidants, polyunsaturated fatty acids), intellectual activity
What are risk factors for AD? - answer Age (greatest risk), Family history,
Genetics (heredity); DM2, HTN, High cholesterol, cerebrovascular disease,
body weight, smoking, depressive symptoms, stress, traumatic brain
injury
What physiologic factor will improve the elimination of memantine? renal
elimination!! - answer Low pH (acidic) urine can increase renal clearance
of memantine
Review the mechanism of action and dosing forms/recommendations for
donepezil - answer blocks enzyme that degrades acetylcholine in brain,
increasing acetylcholine at synaptic cleft and enhances cholinergic
transmission. 5mg/day x4-6wks, 10mg/day x3 months, 23mg/day if all else
fails.
Review the mechanism of action and dosing forms/recommendations for
rivastigmine - answer cholinesterase inhibitor, blocks the action of
acetylcholinesterase, the enzyme responsible for destruction of
acetylcholine. 1.5mg BID, increased every 4wks to 3-6mg BID for
parkinson's
Review the mechanism of action and dosing forms/recommendations for
galantamine - answer cholinesterase inhibitor, structurally different than
other cholinesterase inhibitors. Reversible inhibition of
acetylcholinesterase, which prevents the hydrolysis of acetychdoline,
leading to an increased concentration of acetylcholine at cholinergic
synapses. 4mg BID, for several weeks, then continue at 8-12mg BID; When
using extended release then 8-12mg once daily in the AM.
correct answers (latest update)
What factors are thought to be somewhat protective for Alzheimer's-type
dementia (AD)? - answer caffeine, exercise, diet (high in fish, fruits,
vegetables, antioxidants, polyunsaturated fatty acids), intellectual activity
What are risk factors for AD? - answer Age (greatest risk), Family history,
Genetics (heredity); DM2, HTN, High cholesterol, cerebrovascular disease,
body weight, smoking, depressive symptoms, stress, traumatic brain
injury
What physiologic factor will improve the elimination of memantine? renal
elimination!! - answer Low pH (acidic) urine can increase renal clearance
of memantine
Review the mechanism of action and dosing forms/recommendations for
donepezil - answer blocks enzyme that degrades acetylcholine in brain,
increasing acetylcholine at synaptic cleft and enhances cholinergic
transmission. 5mg/day x4-6wks, 10mg/day x3 months, 23mg/day if all else
fails.
Review the mechanism of action and dosing forms/recommendations for
rivastigmine - answer cholinesterase inhibitor, blocks the action of
acetylcholinesterase, the enzyme responsible for destruction of
acetylcholine. 1.5mg BID, increased every 4wks to 3-6mg BID for
parkinson's
Review the mechanism of action and dosing forms/recommendations for
galantamine - answer cholinesterase inhibitor, structurally different than
other cholinesterase inhibitors. Reversible inhibition of
acetylcholinesterase, which prevents the hydrolysis of acetychdoline,
leading to an increased concentration of acetylcholine at cholinergic
synapses. 4mg BID, for several weeks, then continue at 8-12mg BID; When
using extended release then 8-12mg once daily in the AM.
