Immunology: Chapter 6 Test Bank/
Latest Update
Negative selection of developing B cells ensures that - CORRECT ANSWERS -B-cell
receptors that bind to normal constituents of the body do not emerge
Receptor editing occurs _____. (Select all that apply.) - CORRECT ANSWERS --in the
bone marrow
-to establish self-tolerance of the B-cell repertoire
Which of the following statements about the IgD made by B cells of upper respiratory
mucosa is not true? - CORRECT ANSWERS -Two-thirds of these IgD antibodies
possess κ light chains.
Individuals who fail to express functional Bruton's tyrosine kinase exhibit all of the
following characteristics except - CORRECT ANSWERS -B-cell development is blocked
at the immature B-cell stage
All of the following are associated with the development of Burkitt's lymphoma except -
CORRECT ANSWERS -Overproduction of the Bcl-2 protein prolongs the lifetime of B-
lineage cells.
Which of the following is a characteristic of B-2 cells? - CORRECT ANSWERS -They
are located primarily in secondary lymphoid organs.
Plasma cells have all of the properties listed except - CORRECT ANSWERS -they
rapidly proliferate in secondary lymphoid follicles
All of the following events occur within germinal centers except - CORRECT ANSWERS
-B cells are activated by CD4 helper T cells
In which location would plasma cells not be present? - CORRECT ANSWERS -afferent
lymphatic vessels
Immunological tolerance in the B-cell repertoire is called _______ tolerance when it
develops in primary lymphoid organs, and _______ tolerance when it is induced outside
the bone marrow. - CORRECT ANSWERS -central; peripheral.
The proto-oncogene _______ is associated with the development of Burkitt's
lymphoma. - CORRECT ANSWERS -Myc
What is the fate of an immature B cell that encounters and has specificity for self
antigen? - CORRECT ANSWERS -Continued rearrangement of light-chain genes.
Latest Update
Negative selection of developing B cells ensures that - CORRECT ANSWERS -B-cell
receptors that bind to normal constituents of the body do not emerge
Receptor editing occurs _____. (Select all that apply.) - CORRECT ANSWERS --in the
bone marrow
-to establish self-tolerance of the B-cell repertoire
Which of the following statements about the IgD made by B cells of upper respiratory
mucosa is not true? - CORRECT ANSWERS -Two-thirds of these IgD antibodies
possess κ light chains.
Individuals who fail to express functional Bruton's tyrosine kinase exhibit all of the
following characteristics except - CORRECT ANSWERS -B-cell development is blocked
at the immature B-cell stage
All of the following are associated with the development of Burkitt's lymphoma except -
CORRECT ANSWERS -Overproduction of the Bcl-2 protein prolongs the lifetime of B-
lineage cells.
Which of the following is a characteristic of B-2 cells? - CORRECT ANSWERS -They
are located primarily in secondary lymphoid organs.
Plasma cells have all of the properties listed except - CORRECT ANSWERS -they
rapidly proliferate in secondary lymphoid follicles
All of the following events occur within germinal centers except - CORRECT ANSWERS
-B cells are activated by CD4 helper T cells
In which location would plasma cells not be present? - CORRECT ANSWERS -afferent
lymphatic vessels
Immunological tolerance in the B-cell repertoire is called _______ tolerance when it
develops in primary lymphoid organs, and _______ tolerance when it is induced outside
the bone marrow. - CORRECT ANSWERS -central; peripheral.
The proto-oncogene _______ is associated with the development of Burkitt's
lymphoma. - CORRECT ANSWERS -Myc
What is the fate of an immature B cell that encounters and has specificity for self
antigen? - CORRECT ANSWERS -Continued rearrangement of light-chain genes.
