PCB 3233 - EXAM 2 QUESTIONS AND ANSWERS
How many classes of antibodies are there and what are they? - Answers-Five
chemically and physically distinct classes of antibodies (IgG, IgA, IgM, IgD, IgE)
How are antibodies produced? - Answers-•Produced by the B lymphocytes in response
to infection
What is the relationship between antibodies and antigens? - Answers-Antigens are
bound by antibodies
What are antigens? - Answers-Antigens are biological macromolecules
What are the most common antigens - Answers-•Proteins and carbohydrates most
common antigens
Antibodies are the secreted form of.... - Answers-Proteins known more generally as
immunoglobulins (Igs)
Which cells express lgs on their surface? - Answers-•Mature B cells express Igs (B cell
receptor or BCR) on their surface
•Both BCRs and Abs are referred to as ________ - Answers-Immunoglobins
What happens when Ag binds Igs? - Answers-The B cell proliferates and then
differentiates into a plasma cell
Plasma cell secretes Ab with same specificity as ______ - Answers-the membrane-
bound Igs
Papain cleaves the IgG molecule into how many pieces, and what are those pieces
called? - Answers-Papain cleaves the IgG molecule into three pieces:
•Two Fab (fragment antigen binding) fragments
•One Fc fragment (fragment crystallizable)
What is the two fab fragment? - Answers-It is antigen binding part of the IgG molecule
when it is cleaved off
What is the one Fc fragment? - Answers-•Part responsible for effector functions
•Binds to Fc receptors on phagocytes, mast cells, basophils...
•Determines the fate of the antigen that is bound to the antibody
Beginning of ch. 3 flashcards: What are the three lines of defense and what is their time
of onset? - Answers-1. Immediate innate immune response (0-4 hours)
2. Induced innate immune response (4 hours to 4 days)
How many classes of antibodies are there and what are they? - Answers-Five
chemically and physically distinct classes of antibodies (IgG, IgA, IgM, IgD, IgE)
How are antibodies produced? - Answers-•Produced by the B lymphocytes in response
to infection
What is the relationship between antibodies and antigens? - Answers-Antigens are
bound by antibodies
What are antigens? - Answers-Antigens are biological macromolecules
What are the most common antigens - Answers-•Proteins and carbohydrates most
common antigens
Antibodies are the secreted form of.... - Answers-Proteins known more generally as
immunoglobulins (Igs)
Which cells express lgs on their surface? - Answers-•Mature B cells express Igs (B cell
receptor or BCR) on their surface
•Both BCRs and Abs are referred to as ________ - Answers-Immunoglobins
What happens when Ag binds Igs? - Answers-The B cell proliferates and then
differentiates into a plasma cell
Plasma cell secretes Ab with same specificity as ______ - Answers-the membrane-
bound Igs
Papain cleaves the IgG molecule into how many pieces, and what are those pieces
called? - Answers-Papain cleaves the IgG molecule into three pieces:
•Two Fab (fragment antigen binding) fragments
•One Fc fragment (fragment crystallizable)
What is the two fab fragment? - Answers-It is antigen binding part of the IgG molecule
when it is cleaved off
What is the one Fc fragment? - Answers-•Part responsible for effector functions
•Binds to Fc receptors on phagocytes, mast cells, basophils...
•Determines the fate of the antigen that is bound to the antibody
Beginning of ch. 3 flashcards: What are the three lines of defense and what is their time
of onset? - Answers-1. Immediate innate immune response (0-4 hours)
2. Induced innate immune response (4 hours to 4 days)
