BPS 2110 - HGH EXAM QUESTIONS AND ANSWERS
HGH
human growth hormone
human growth hormone
- somatotropin
- 191 amino acid protein
HGH secreted by
pituitary gland
HGH stimulates
growth, cell regeneration
important for development, repair
- secreted throughout life: 400 ug/day (adult)
- larger amounts produced during growth: 700 ug/ day (adolescent)
HGH deficiency
- hypopituitary dwarfism: short stature, short digits, limited elboe mobility, lower back
issues
- rare condition
- pituitary does not produce enough HGH
treatment with human growth hormone
, - HGH has to be extracted and then purified from Human cadavers
- animal source GH is ineffective in humans
- supply: only the FDA-approved use was hypopituitary dwarfish
Cadaveric Harvest of HGH
- removal of brain-cut out pituitary
- small amount of brain tissue commonly included
- requires approximately 8 cadavers/year/child
- injections once a week
- for 10 to 12 years
It is impossible to purify anything 100%
proteins from living sources always contain small amounts of contamination
proteins
may cause allergy
enzymes (shelf life)
other functioning protein (various effects)
viruses
may cuases infectious disease
purification include special anti-viral steps
Creutzfeldt-Jakob disease
progressive, incurable, neurologic disease caused by infectious prions
transmissible spongiform encephalopathies
100 % fatal brain disorders
death approx. 1 year after diagnosis
no treatment
dementia, blindness, involuntary movements, strange behaviors
characterized by formation of amyloid plaques: destroy brain tissue
HGH
human growth hormone
human growth hormone
- somatotropin
- 191 amino acid protein
HGH secreted by
pituitary gland
HGH stimulates
growth, cell regeneration
important for development, repair
- secreted throughout life: 400 ug/day (adult)
- larger amounts produced during growth: 700 ug/ day (adolescent)
HGH deficiency
- hypopituitary dwarfism: short stature, short digits, limited elboe mobility, lower back
issues
- rare condition
- pituitary does not produce enough HGH
treatment with human growth hormone
, - HGH has to be extracted and then purified from Human cadavers
- animal source GH is ineffective in humans
- supply: only the FDA-approved use was hypopituitary dwarfish
Cadaveric Harvest of HGH
- removal of brain-cut out pituitary
- small amount of brain tissue commonly included
- requires approximately 8 cadavers/year/child
- injections once a week
- for 10 to 12 years
It is impossible to purify anything 100%
proteins from living sources always contain small amounts of contamination
proteins
may cause allergy
enzymes (shelf life)
other functioning protein (various effects)
viruses
may cuases infectious disease
purification include special anti-viral steps
Creutzfeldt-Jakob disease
progressive, incurable, neurologic disease caused by infectious prions
transmissible spongiform encephalopathies
100 % fatal brain disorders
death approx. 1 year after diagnosis
no treatment
dementia, blindness, involuntary movements, strange behaviors
characterized by formation of amyloid plaques: destroy brain tissue
