NR-293
Pharmacology for NP
FINAL READINESS EXAM
Q&S
©2024/2025
,1. Which phase of pharmacokinetics is primarily affected by
liver function?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Answer: C. Metabolism
Rationale: The liver is the primary site of drug
metabolism, transforming drugs into more water-soluble
compounds for excretion.
2. In the context of drug-receptor interactions, a drug that
binds to a receptor and activates it is called a(n):
A. Antagonist
B. Agonist
C. Partial agonist
D. Inverse agonist
Answer: B. Agonist
Rationale: Agonists bind to receptors and mimic the
action of endogenous substances, activating the receptor.
3. The therapeutic index of a drug is a ratio of:
A. Efficacy to potency
B. Toxic dose to therapeutic dose
C. Absorption to distribution rate
D. Half-life to bioavailability
Answer: B. Toxic dose to therapeutic dose
Rationale: The therapeutic index measures drug safety;
a higher index indicates a wider margin between effective
and toxic doses.
©2024/2025
, 4. Which drug delivery route is most likely to avoid first-pass
metabolism?
A. Oral
B. Rectal
C. Intravenous
D. Subcutaneous
Answer: C. Intravenous
Rationale: Intravenous administration bypasses the
gastrointestinal system, hence avoiding first-pass
metabolism by the liver.
5. A competitive antagonist:
A. Permanently deactivates the receptor
B. Competes with the agonist for the same binding site
C. Enhances the efficacy of the agonist
D. Alters the receptor’s conformation
Answer: B. Competes with the agonist for the same
binding site
Rationale: Competitive antagonists bind reversibly to
the active site, inhibiting the action of agonists.
### Fill-in-the-Blank Questions
6. ________ is the process by which a drug moves from its
site of administration into the bloodstream.
Answer: Absorption
Rationale: Absorption refers to the movement of a drug
from its administration site into systemic circulation.
7. The ________ is the time it takes for the concentration of
a drug in the plasma to decrease by half.
Answer: Half-life
©2024/2025
Pharmacology for NP
FINAL READINESS EXAM
Q&S
©2024/2025
,1. Which phase of pharmacokinetics is primarily affected by
liver function?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Answer: C. Metabolism
Rationale: The liver is the primary site of drug
metabolism, transforming drugs into more water-soluble
compounds for excretion.
2. In the context of drug-receptor interactions, a drug that
binds to a receptor and activates it is called a(n):
A. Antagonist
B. Agonist
C. Partial agonist
D. Inverse agonist
Answer: B. Agonist
Rationale: Agonists bind to receptors and mimic the
action of endogenous substances, activating the receptor.
3. The therapeutic index of a drug is a ratio of:
A. Efficacy to potency
B. Toxic dose to therapeutic dose
C. Absorption to distribution rate
D. Half-life to bioavailability
Answer: B. Toxic dose to therapeutic dose
Rationale: The therapeutic index measures drug safety;
a higher index indicates a wider margin between effective
and toxic doses.
©2024/2025
, 4. Which drug delivery route is most likely to avoid first-pass
metabolism?
A. Oral
B. Rectal
C. Intravenous
D. Subcutaneous
Answer: C. Intravenous
Rationale: Intravenous administration bypasses the
gastrointestinal system, hence avoiding first-pass
metabolism by the liver.
5. A competitive antagonist:
A. Permanently deactivates the receptor
B. Competes with the agonist for the same binding site
C. Enhances the efficacy of the agonist
D. Alters the receptor’s conformation
Answer: B. Competes with the agonist for the same
binding site
Rationale: Competitive antagonists bind reversibly to
the active site, inhibiting the action of agonists.
### Fill-in-the-Blank Questions
6. ________ is the process by which a drug moves from its
site of administration into the bloodstream.
Answer: Absorption
Rationale: Absorption refers to the movement of a drug
from its administration site into systemic circulation.
7. The ________ is the time it takes for the concentration of
a drug in the plasma to decrease by half.
Answer: Half-life
©2024/2025
