Test Bank For Basic and Clinical Pharmacology 16th Edition by Bertram G. Katzung||ISBN NO-10,1260463303||ISBN NO-13,978-1260463309 ||chapter 1-15||Complete Guide A++

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BASIC AND CLINICAL PHARMACOLOGY 16th
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Basic and Clinical Pharmacology 14th Edition Katzung Trevor Test Bank
EDITION
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Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation
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1. A nurse working in radiology administers iodine to a patient who is
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having a computed tomography (CT) scan. The nurse working on the
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oncology unit administers chemotherapy to patients who have cancer. At
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the Public Health Department, a nurse administers a measles-mumps-
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rubella (MMR) vaccine toa 14-month-old zchildzaszazroutine immunization.
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Which branch of pharmacology zbest zdescribes zthe zactions zof zall zthree
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nurses?
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A) Pharmacoeconomics

B) Pharmacotherapeutics

C) Pharmacodynamics

D) Pharmacokinetics

Ans: B

Feedback:

Pharmacology zis zthe zstudy zof zthe zbiologic zeffects zofzchemicals. Nurses are
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involved zwith zclinical zpharmacology zor zpharmacotherapeutics, which is a
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zbranch zof zpharmacology zthat zdeals zwith zthe zuses z of z drugs zto ztreat, prevent,
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zand zdiagnose zdisease. zThe zradiology z nurse z is z administering za zdrug zto help
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zdiagnose za zdisease.zThe z oncology znurse z is zadministering za zdrug to help treat
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zazdisease. zPharmacoeconomics z includes zany costs involved z in zdrug therapy.
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Pharmacodynamics involves how a drug affects the body
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andpharmacokinetics is how the body acts on the body.
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2. A physician has ordered intramuscular (IM) injections of morphine, a
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narcotic, every 4 hours as needed for pain in a motor vehicle accident
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victim.The nurse is aware this drug has a high abuse potential. Under
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whatcategorywould morphine be classified?
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A) Schedule I u




B) Schedule II u




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C) Schedule III u




D) Schedule IV u




Ans: B

Feedback:

Narcotics with a high abuse potential are classified as Schedule II drugs
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because of severe dependence liability. Schedule I drugs have high
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abusepotential and no accepted medical use. Schedule III drugs have a
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lesser abuse potential than II and an accepted medical use. Schedule IV
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drugs havelow abuse potential and limited dependence liability.
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3. When involved zin zphasezIII zdrug zevaluation studies, what
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responsibilitieszwould zthe znurse z have?
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A) Working zwith zanimals zwho zare zgiven zexperimental z drugs u u




B) Choosing zappropriate zpatients zto zbe zinvolved zinzthezdrug study u u u u u




C) Monitoring zand zobserving zpatients zclosely zfor zadverse effects uu




D) Conducting zresearch zto zdetermine zeffectiveness zof zthe z drug u u




Ans: C

Feedback:

Phase zIII zstudies zinvolve zuse zof za zdrug zin zazvast zclinical zpopulation in u u


zwhichzpatients zare zasked zto zrecord zany zsymptoms zthey zexperience while
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ztaking z thezdrugs. zNurses zmay zbe zresponsible z for z helping zcollect zand
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zanalyze zthe z information zto zbe zshared zwith zthe zFood zand zDrug
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zAdministration z(FDA)zbutzwould z not z conduct zresearch independently
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because nurses do not prescribe medications. Use of animals in drug
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testing is done in the preclinical trials. Select patients who are involved
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in phase II studies to participate in studies where the participants have
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thedisease the drug is intended to treat. These patients are monitored
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closely for drug action and adverse effects. Phase I studies involve
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healthy human volunteers who are usually paid for their participation.
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Nurses
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may observe for adverse effects and toxicity.
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4. What concept is considered when generic drugs are substituted
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forbrandname drugs?
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A) Bioavailability

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B) Critical concentration u




C) Distribution

D) Half-life

Ans: A

Feedback:

Bioavailability is the portion of a dose of a drug that reaches the systemic
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circulation and is available to act on body cells. Binders used in a generic
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drug may not be the same as those used in the brand name drug.
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Therefore, the way the body breaks down and uses the drug may differ,
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u which may eliminate a generic drug substitution. Critical concentration
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u isthe amount ofa zdrug zthat zis zneeded zto zcause za ztherapeutic effect and
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u should not zdiffer zbetween zgeneric zand zbrand zname medications.
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Distribution zis zthe zphase zof zpharmacokinetics, zwhich involves the
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umovement zof za zdrug zto zthe zbodys ztissues zand zis zthe zsame in generic and u u u u u u u


uzbrand z name zdrugs. zA zdrugs z half-life z iszt he ztime zit ztakes z for the amount of
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uzdrug zto zdecrease zto z half z the zpeak z level, zwhich zshould znot zchange when
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zsubstituting za zgeneric z medication. u u u




5. A znurse ziszassessing zthe zpatientszhome zmedication zuse. zAfter listening to
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zthezpatient z list zcurrent zmedications, zthe z nurse zasks zwhat zpriority question?
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A) Do zyou ztake zany zgeneric zmedications? u




B) Are zany zof zthese zmedications zorphan z drugs? u




C) Are zthese zmedications zsafe zto ztake zduring z pregnancy? u u




D) Do zyou ztake zany zover-the-counter z medications?
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Ans: D

Feedback:

It is important for the nurse to specifically question use of over-the-
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countermedications because patients may not consider them important.
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The patient is unlikely to know the meaning of orphan drugs unless they
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too are health care providers. Safety during pregnancy, use of a generic
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medication, or classification of orphan drugs are things the patient
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would be unable to answer but could be found in reference books if the
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nurse wishes to researchthem.
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