ONS Chemotherapy Immunotherapy
Certificate Exam 100% Correct!!
Define neoadjuvant therapy - ANSWERTreatment is given prior to surgery to shrink the tumor
Define adjuvant therapy - ANSWERAdditional cancer treatment given after the primary treatment to
lower the risk that the cancer reoccur
3 subcategories of alkylating agents: - ANSWER1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they
work similarly)
3. Nitrosoureas
Common alkylating agents: - ANSWERCyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: - ANSWERCisplatin (Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? - ANSWERAble to cross the blood-brain barrier; can be
effective in treating some brain tumors
Common nitrosoureas agents: - ANSWERCarmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - ANSWERCarboplatin
These agents are typically categorized as highly emetogenic: - ANSWER1. Alkylating agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and nitrosoureas: - ANSWERBUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? - ANSWERBladder protectant with administration of
cyclophosphamide or ifosfamide
Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-4 days
following treatment - ANSWEROxaliplatin
How do antimetabolites function? - ANSWERBy blocking DNA and RNA growth by interfering with
enzymes needed for normal cell metabolism
, Antimetabolites work in the ___ phase. - ANSWERS
Common side effects of antimetabolites: - ANSWERMyelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome
Common antimetabolite drugs: - ANSWERAzacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
The institute for Safe Medication Practices recommends what route of administration for vincristine?
- ANSWERIV piggyback via gravity
Anthracycline antitumor abx work by: - ANSWERInterfering with enzymes necessary for DNA to
replicate in ALL phases of the cell cycle
The two major classifications of antitumor antibiotics are: - ANSWERAnthracyclines
Non-anthracyclines
Common anthracycline antitumor abx: - ANSWERDaunorubicin
Doxorubicin
Epirubicin
Idarubicin
The antitumor abx ___________ is not an anthracycline, but has anthracycline-type properties. -
ANSWERMitoxantrone
Common non-anthracycline antitumor abx: - ANSWERActinomycin D
Mitomycin C
Bleomycin
Monitoring necessary with doxorubicin: - ANSWERVesicant --> extravasation
Cardiac function
Lifetime dose tracking (cardiotoxicity)
Lifetime dose of doxorubicin should not exceed: - ANSWER550 mg/m^2
What cardiac protectant medication can be administered prior to doxorubicin? -
ANSWERDexrazoxane
Certificate Exam 100% Correct!!
Define neoadjuvant therapy - ANSWERTreatment is given prior to surgery to shrink the tumor
Define adjuvant therapy - ANSWERAdditional cancer treatment given after the primary treatment to
lower the risk that the cancer reoccur
3 subcategories of alkylating agents: - ANSWER1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they
work similarly)
3. Nitrosoureas
Common alkylating agents: - ANSWERCyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: - ANSWERCisplatin (Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? - ANSWERAble to cross the blood-brain barrier; can be
effective in treating some brain tumors
Common nitrosoureas agents: - ANSWERCarmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - ANSWERCarboplatin
These agents are typically categorized as highly emetogenic: - ANSWER1. Alkylating agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and nitrosoureas: - ANSWERBUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? - ANSWERBladder protectant with administration of
cyclophosphamide or ifosfamide
Instruct pts receiving ________ to avoid exposure to cold air and consuming cold fluids for 3-4 days
following treatment - ANSWEROxaliplatin
How do antimetabolites function? - ANSWERBy blocking DNA and RNA growth by interfering with
enzymes needed for normal cell metabolism
, Antimetabolites work in the ___ phase. - ANSWERS
Common side effects of antimetabolites: - ANSWERMyelosuppression
GI toxicities
Photosensitivity
Hand-foot syndrome
Common antimetabolite drugs: - ANSWERAzacitidine
Capecitabine
5-FU
Cytarabine
Decitabine
Methotrexate
The institute for Safe Medication Practices recommends what route of administration for vincristine?
- ANSWERIV piggyback via gravity
Anthracycline antitumor abx work by: - ANSWERInterfering with enzymes necessary for DNA to
replicate in ALL phases of the cell cycle
The two major classifications of antitumor antibiotics are: - ANSWERAnthracyclines
Non-anthracyclines
Common anthracycline antitumor abx: - ANSWERDaunorubicin
Doxorubicin
Epirubicin
Idarubicin
The antitumor abx ___________ is not an anthracycline, but has anthracycline-type properties. -
ANSWERMitoxantrone
Common non-anthracycline antitumor abx: - ANSWERActinomycin D
Mitomycin C
Bleomycin
Monitoring necessary with doxorubicin: - ANSWERVesicant --> extravasation
Cardiac function
Lifetime dose tracking (cardiotoxicity)
Lifetime dose of doxorubicin should not exceed: - ANSWER550 mg/m^2
What cardiac protectant medication can be administered prior to doxorubicin? -
ANSWERDexrazoxane
