PCB 3233 - Exam 2
How many classes of antibodies are there and what are they? - correct answer ✔✔Five chemically and
physically distinct classes of antibodies (IgG, IgA, IgM, IgD, IgE)
How are antibodies produced? - correct answer ✔✔•Produced by the B lymphocytes in response to
infection
What is the relationship between antibodies and antigens? - correct answer ✔✔Antigens are bound by
antibodies
What are antigens? - correct answer ✔✔Antigens are biological macromolecules
What are the most common antigens - correct answer ✔✔•Proteins and carbohydrates most common
antigens
Antibodies are the secreted form of.... - correct answer ✔✔Proteins known more generally as
immunoglobulins (Igs)
Which cells express lgs on their surface? - correct answer ✔✔•Mature B cells express Igs (B cell receptor
or BCR) on their surface
•Both BCRs and Abs are referred to as ________ - correct answer ✔✔Immunoglobins
What happens when Ag binds Igs? - correct answer ✔✔The B cell proliferates and then differentiates
into a plasma cell
Plasma cell secretes Ab with same specificity as ______ - correct answer ✔✔the membrane-bound Igs
, Papain cleaves the IgG molecule into how many pieces, and what are those pieces called? - correct
answer ✔✔Papain cleaves the IgG molecule into three pieces:
•Two Fab (fragment antigen binding) fragments
•One Fc fragment (fragment crystallizable)
What is the two fab fragment? - correct answer ✔✔It is antigen binding part of the IgG molecule when it
is cleaved off
What is the one Fc fragment? - correct answer ✔✔•Part responsible for effector functions
•Binds to Fc receptors on phagocytes, mast cells, basophils...
•Determines the fate of the antigen that is bound to the antibody
Beginning of ch. 3 flashcards: What are the three lines of defense and what is their time of onset? -
correct answer ✔✔1. Immediate innate immune response (0-4 hours)
2. Induced innate immune response (4 hours to 4 days)
3. Adaptive immune response: 4 days until the defeat of the pathogen, defeat of the host, or
compromise of the chronic disease
When does the induced innate response take place - correct answer ✔✔Once the pathogen has
breached the physical barriers and outrun the initial response
Two examples of Cells that use receptors to recognize self from non-self are: - correct answer
✔✔Macrophages and NK cells
Both cell types need to be able to differentiate between: - correct answer ✔✔Host and pathogen
What are the two key phase reactants we already talked about? - correct answer ✔✔CRP and NBL
What provides a first line of cellular defense against invading microorganisms? - correct answer
✔✔Phagocytosis by macrophages
How many classes of antibodies are there and what are they? - correct answer ✔✔Five chemically and
physically distinct classes of antibodies (IgG, IgA, IgM, IgD, IgE)
How are antibodies produced? - correct answer ✔✔•Produced by the B lymphocytes in response to
infection
What is the relationship between antibodies and antigens? - correct answer ✔✔Antigens are bound by
antibodies
What are antigens? - correct answer ✔✔Antigens are biological macromolecules
What are the most common antigens - correct answer ✔✔•Proteins and carbohydrates most common
antigens
Antibodies are the secreted form of.... - correct answer ✔✔Proteins known more generally as
immunoglobulins (Igs)
Which cells express lgs on their surface? - correct answer ✔✔•Mature B cells express Igs (B cell receptor
or BCR) on their surface
•Both BCRs and Abs are referred to as ________ - correct answer ✔✔Immunoglobins
What happens when Ag binds Igs? - correct answer ✔✔The B cell proliferates and then differentiates
into a plasma cell
Plasma cell secretes Ab with same specificity as ______ - correct answer ✔✔the membrane-bound Igs
, Papain cleaves the IgG molecule into how many pieces, and what are those pieces called? - correct
answer ✔✔Papain cleaves the IgG molecule into three pieces:
•Two Fab (fragment antigen binding) fragments
•One Fc fragment (fragment crystallizable)
What is the two fab fragment? - correct answer ✔✔It is antigen binding part of the IgG molecule when it
is cleaved off
What is the one Fc fragment? - correct answer ✔✔•Part responsible for effector functions
•Binds to Fc receptors on phagocytes, mast cells, basophils...
•Determines the fate of the antigen that is bound to the antibody
Beginning of ch. 3 flashcards: What are the three lines of defense and what is their time of onset? -
correct answer ✔✔1. Immediate innate immune response (0-4 hours)
2. Induced innate immune response (4 hours to 4 days)
3. Adaptive immune response: 4 days until the defeat of the pathogen, defeat of the host, or
compromise of the chronic disease
When does the induced innate response take place - correct answer ✔✔Once the pathogen has
breached the physical barriers and outrun the initial response
Two examples of Cells that use receptors to recognize self from non-self are: - correct answer
✔✔Macrophages and NK cells
Both cell types need to be able to differentiate between: - correct answer ✔✔Host and pathogen
What are the two key phase reactants we already talked about? - correct answer ✔✔CRP and NBL
What provides a first line of cellular defense against invading microorganisms? - correct answer
✔✔Phagocytosis by macrophages
