PCB 3233 Exam 6 Study Guide Chapter
14 & 15
What is the major vasoactive molecule stored in mast cell granules? Hint: starts with an H. - correct
answer ✔✔Histamine.
Smooth muscle constriction
Lower BP by allowing vascular permeability
Increased mucosal secretion
Which synthesized molecules act most like histamine in the late phase reaction but are much more
potent than histamine? - correct answer ✔✔Leukotrienes. It prolongs smooth muscle contraction.
Define allergic reaction - correct answer ✔✔Are exaggerated immune system responses that are
inappropriate and damaging to tissues.
What are the 4 types of hyper sensitivity reactions and what are they mediated by? - correct answer
✔✔Type I = IgE mediated Mast, Basophil and eosinophils. Ex. pollen
Type II = IgM and IgG Ab's; complement activation and results in cell lysis. Ex. Penicillin
Type III = IgG and IgM; immune complex rxns, Ex. non-human therapeutic proteins.
Type IV = cell mediated immunity. Caused by T-cells. Delayed type hypersensitivity.
Allergy serum sickness - correct answer ✔✔The immune system reacts to medicines that contain
proteins used to treat immune conditions. Or it can react to antiserum, the liquid part of blood that
contains antibodies given to a person to help protect them against germs or poisonous substances
Eczema - correct answer ✔✔Atopic dermatitis, more prolonged allergic response in the skin.
Arthus - correct answer ✔✔Type III hypersensitivity.
14 & 15
What is the major vasoactive molecule stored in mast cell granules? Hint: starts with an H. - correct
answer ✔✔Histamine.
Smooth muscle constriction
Lower BP by allowing vascular permeability
Increased mucosal secretion
Which synthesized molecules act most like histamine in the late phase reaction but are much more
potent than histamine? - correct answer ✔✔Leukotrienes. It prolongs smooth muscle contraction.
Define allergic reaction - correct answer ✔✔Are exaggerated immune system responses that are
inappropriate and damaging to tissues.
What are the 4 types of hyper sensitivity reactions and what are they mediated by? - correct answer
✔✔Type I = IgE mediated Mast, Basophil and eosinophils. Ex. pollen
Type II = IgM and IgG Ab's; complement activation and results in cell lysis. Ex. Penicillin
Type III = IgG and IgM; immune complex rxns, Ex. non-human therapeutic proteins.
Type IV = cell mediated immunity. Caused by T-cells. Delayed type hypersensitivity.
Allergy serum sickness - correct answer ✔✔The immune system reacts to medicines that contain
proteins used to treat immune conditions. Or it can react to antiserum, the liquid part of blood that
contains antibodies given to a person to help protect them against germs or poisonous substances
Eczema - correct answer ✔✔Atopic dermatitis, more prolonged allergic response in the skin.
Arthus - correct answer ✔✔Type III hypersensitivity.
