NU 643 FINAL EXAM STUDY GUIDE
LATEST AND UPDATED REGIS COLLEGE.
Inverse agonist binding
✔✔cause inactivation of signal transduction
A neurotransmitter binds to a receptor
✔✔causing electrical impulses to travel the neuron's axon; it eventually
releases the neurotransmitter and repeats the process with a postsynaptic
neuron, classical synaptic neurotransmission
True of pharmacokinetics
✔✔Accumulation of psychotropic drugs occurs faster in the brain than
adipose tissue
CYP450 TABLE
✔✔inhibitors and substrates INCREASE effectiveness of drug metabolized
inducers DECREASE effectiveness
Two main targets of signal transduction
✔✔gene expression and phosphoproteins
antagonist binding to receptor
✔✔unchanged signal transduction
first pass effect
✔✔metabolism of the drug in the liver, prior to reaching systemic
circulation
,Partial agonist binding to receptor
✔✔signal transduction is partially enhanced
Phase 1 metabolism
✔✔CYP450 enzyme activity
Phase 2 metabolism
✔✔conjugation of drug
G-linked proteins
✔✔bind enzymes that synthesize second messenger
Enzyme inhibition as a target of drug therapies
✔✔a means of preventing the degradation of neurotransmitters
ligand-gated ion channel
✔✔Allosteric modulators can enhance or inhibit ion channels when in the
presence of neurotransmitter
agonist binding to receptor
✔✔singal transduction is fully enhanced antagonist, in the presence of an
agonist, can return a channel to resting state
retrograde neurotransmission
✔✔the flow of neurotransmitter from postsynaptic neuron to presynaptic
neuron
, pharmacodynamics
✔✔action of drugs on body
pharmacokinetics
✔✔action of body on drugs
concentration-time curve of medication absorption
✔✔Steady-state refers to the point at which blood level fluctuations are
mild and not clinically significant.
volume neurotransmission
✔✔the diffusion of neurotransmitter to nearby neurons
second messengers
✔✔intracellular messengers activated by extracellular messengers
The direct role of transcription factors is to
✔✔influence gene expression
buproprion
✔✔wellbutrin....SNRI....may have affect for ADHD
comparing desvenlafaxine to venlafaxine
✔✔Desvenlafaxine likely no more efficacious venlafaxine
LATEST AND UPDATED REGIS COLLEGE.
Inverse agonist binding
✔✔cause inactivation of signal transduction
A neurotransmitter binds to a receptor
✔✔causing electrical impulses to travel the neuron's axon; it eventually
releases the neurotransmitter and repeats the process with a postsynaptic
neuron, classical synaptic neurotransmission
True of pharmacokinetics
✔✔Accumulation of psychotropic drugs occurs faster in the brain than
adipose tissue
CYP450 TABLE
✔✔inhibitors and substrates INCREASE effectiveness of drug metabolized
inducers DECREASE effectiveness
Two main targets of signal transduction
✔✔gene expression and phosphoproteins
antagonist binding to receptor
✔✔unchanged signal transduction
first pass effect
✔✔metabolism of the drug in the liver, prior to reaching systemic
circulation
,Partial agonist binding to receptor
✔✔signal transduction is partially enhanced
Phase 1 metabolism
✔✔CYP450 enzyme activity
Phase 2 metabolism
✔✔conjugation of drug
G-linked proteins
✔✔bind enzymes that synthesize second messenger
Enzyme inhibition as a target of drug therapies
✔✔a means of preventing the degradation of neurotransmitters
ligand-gated ion channel
✔✔Allosteric modulators can enhance or inhibit ion channels when in the
presence of neurotransmitter
agonist binding to receptor
✔✔singal transduction is fully enhanced antagonist, in the presence of an
agonist, can return a channel to resting state
retrograde neurotransmission
✔✔the flow of neurotransmitter from postsynaptic neuron to presynaptic
neuron
, pharmacodynamics
✔✔action of drugs on body
pharmacokinetics
✔✔action of body on drugs
concentration-time curve of medication absorption
✔✔Steady-state refers to the point at which blood level fluctuations are
mild and not clinically significant.
volume neurotransmission
✔✔the diffusion of neurotransmitter to nearby neurons
second messengers
✔✔intracellular messengers activated by extracellular messengers
The direct role of transcription factors is to
✔✔influence gene expression
buproprion
✔✔wellbutrin....SNRI....may have affect for ADHD
comparing desvenlafaxine to venlafaxine
✔✔Desvenlafaxine likely no more efficacious venlafaxine
