PUBH 3100
Human Disease & Prevention
FINAL EXAM READINESS GUIDE
Q&S
©2024/2025
,1. Which of the following genetic mutations is most
commonly associated with hereditary breast and ovarian
cancer syndrome?
a) TP53\
b) BRCA1\
c) APC\
d) KRAS\
Answer: b) BRCA1 \
Rationale: BRCA1 mutations are a major risk factor for
hereditary breast and ovarian cancer, significantly
influencing cancer prevention and screening protocols.
2. What is the primary mechanism of action of monoclonal
antibodies used in cancer therapy?
a) Disrupting DNA synthesis in cancer cells\
b) Enhancing immune system response against cancer
cells\
c) Blocking hormonal receptors on cancer cells\
d) Inhibiting cell membrane protein synthesis\
Answer: b) Enhancing immune system response
against cancer cells \
Rationale: Monoclonal antibodies work by specifically
targeting cancer cells, flagging them for the immune system
to attack.
3. Which lifestyle modification is most effective in reducing
the risk of developing Type 2 Diabetes Mellitus?
a) Increasing sodium intake\
b) Regular physical activity\
©2024/2025
, c) High-fat diet\
d) Reduced carbohydrate consumption\
Answer: b) Regular physical activity \
Rationale: Regular physical activity helps manage
blood glucose levels and improves insulin sensitivity, which
are critical for preventing Type 2 Diabetes.
4. The most effective preventive measure against Human
Papillomavirus (HPV) is:
a) Antibiotic therapy\
b) Vaccination\
c) Chemotherapy\
d) Immunosuppressive therapy\
Answer: b) Vaccination \
Rationale: HPV vaccination is highly effective in
preventing the types of HPV that can lead to cervical and
other cancers.
5. Which tissue is primarily affected in Rheumatoid
Arthritis?
a) Adipose tissue\
b) Epithelial tissue\
c) Synovial tissue\
d) Neural tissue\
Answer: c) Synovial tissue \
Rationale: Rheumatoid Arthritis primarily affects the
synovial joints, leading to inflammation and tissue damage.
Fill-in-the-Blank Questions
©2024/2025
Human Disease & Prevention
FINAL EXAM READINESS GUIDE
Q&S
©2024/2025
,1. Which of the following genetic mutations is most
commonly associated with hereditary breast and ovarian
cancer syndrome?
a) TP53\
b) BRCA1\
c) APC\
d) KRAS\
Answer: b) BRCA1 \
Rationale: BRCA1 mutations are a major risk factor for
hereditary breast and ovarian cancer, significantly
influencing cancer prevention and screening protocols.
2. What is the primary mechanism of action of monoclonal
antibodies used in cancer therapy?
a) Disrupting DNA synthesis in cancer cells\
b) Enhancing immune system response against cancer
cells\
c) Blocking hormonal receptors on cancer cells\
d) Inhibiting cell membrane protein synthesis\
Answer: b) Enhancing immune system response
against cancer cells \
Rationale: Monoclonal antibodies work by specifically
targeting cancer cells, flagging them for the immune system
to attack.
3. Which lifestyle modification is most effective in reducing
the risk of developing Type 2 Diabetes Mellitus?
a) Increasing sodium intake\
b) Regular physical activity\
©2024/2025
, c) High-fat diet\
d) Reduced carbohydrate consumption\
Answer: b) Regular physical activity \
Rationale: Regular physical activity helps manage
blood glucose levels and improves insulin sensitivity, which
are critical for preventing Type 2 Diabetes.
4. The most effective preventive measure against Human
Papillomavirus (HPV) is:
a) Antibiotic therapy\
b) Vaccination\
c) Chemotherapy\
d) Immunosuppressive therapy\
Answer: b) Vaccination \
Rationale: HPV vaccination is highly effective in
preventing the types of HPV that can lead to cervical and
other cancers.
5. Which tissue is primarily affected in Rheumatoid
Arthritis?
a) Adipose tissue\
b) Epithelial tissue\
c) Synovial tissue\
d) Neural tissue\
Answer: c) Synovial tissue \
Rationale: Rheumatoid Arthritis primarily affects the
synovial joints, leading to inflammation and tissue damage.
Fill-in-the-Blank Questions
©2024/2025
