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pancreas is connected to? - ✔✔the small intestine
Endocrine islet of langerghans are made up of three cell types -
✔✔Alpha cells, beta cells, and delta cells
Alpha cells make? - ✔✔Glucagon which stimulates glycogen into
glucose glycogenolysis.
Beta cells make - ✔✔Insulin which promotes glycogenesis and lowers
glucose levels
Delta cells make - ✔✔Gastrin and somatostatin
Amylase - ✔✔Break down startch and glycogen. Increased in acute
panncreatitis
Lipase - ✔✔Hydrolyzes fats to make alcohols and fatty acids. Increased
in acute pancreatis.
,Cystic Fibrosis - ✔✔genetic dysfunction of exocrine glands like liver
lungs saliva glands pulmonary disease intestinal malabsorption caused by
lack of pancreatic enzymes excretion
pancreatitis - ✔✔pancreas inflammation seenwith alcohol abuse
gallbladder disorder can be acute or chroniccaused by release of
pancreatic enzymes from cells into surrounding pancreatic tissue
Diabetis mellitus - ✔✔Type I and II and GD notenough insulin that leads
to hyperglycemia and the destruction of beta cells
pancreatic cancer - ✔✔5% survival rate seen in pancreatic dust
insulinoma at the beta cells in islets increased insulin and hypoglycemia
Pancreatic exocrine Function test - ✔✔Secretin. Quantitative fecal fat.
Sweat cl test(pilocarpine nitrate stimulated sweating). Enzyme
testing(amaylase lipase)
Glycogenesis - ✔✔Glycogen formation from glucose
Glycogenolysis - ✔✔Glycogen breakdown to glucose
Glycolysis - ✔✔Catabolism of glucose to pyruvate for ATP
Gluconeogenesis - ✔✔Formation of glucose from aa and lipids
Fasting plasma glucose for diabetes - ✔✔> or = 126 mg/dL
, 2 hr post prandial plasma glucose for diabetes - ✔✔> or = 200 mg/dL
OGTT oralglucose tolerance test for diabetes - ✔✔> or = 200
Nonlactose fermenting, hydrogen sulfide producing, indole and VP negative
but utilises citrate as a source of carbon - ✔✔Salmonella
Rh haplotype among whites - ✔✔DCe
antinuclear antibody (ANA) testing pattern for homogeneous -
✔✔nucleus (nuclei) of the interphase cell smooth staining in the nucleus
of the interphase cells
Chediak-Hegash Syndrome - ✔✔defined as the abnormal fusion of
cytoplasmic lysozymes in granulocytes and occasionally monocytes. This
condition is associated with albino characteristics, photophobia, and
frequent infections (as the granules are dysfunctional and cannot fight
infection appropriately)
Alder-Reilly is associated with - ✔✔genetic mucopoly- saccharidoses.
Patients with mucopolysaccharidoses do not have the lysozymal enzymes
necessary to break down mucopolysaccharides; hence dense azurophilic
granules, resembling toxic granulation in neutrophils, are seen in all
leukocytes.