PHM 714 Exam 2 Questions And Accurate Answers
Testosterone is converted to DHT by the enzyme - Answer 5α-reductase
Adverse effects of GnRH & Its Analogs - Answer Osteoporosis: Reduced bone density
• Tumor flare
• Gynecomastia
• Hot flashes
• Dyslipidemia & Hyperglycemia
• ↓Libido and ED
What are the GnRH Antagonist Analogs? - Answer Relugolix & Degarelix
Which drugs competitively inhibit the binding of testosterone & DHT? - Answer 1st gen:
Flutamide, Bicalutamide (Casodex), Nilutamide (Nilandron)
2nd gen: Apalutamide (Erleada), Darolutamide (Nubeqa) and Enzalutamide (Xtandi)
Which drugs may cause gynecomastia? - Answer Bicalutamide
Nilutamide
Which class of drugs will decrease PSA levels? - Answer Corticosteroids
(Dexamethasone, Prednisone, Methylprednisolone)
What are the Inhibitors of Poly (ADP-Ribose) Polymerase (PARP)? - Answer Olaparib
(Lynparza)
Rucaparib (Rubraca)
, What are the Nonsteroidal Antiandrogens? - Answer Bicalutamide
Flutamide
Nilutamide
Enzalutamide
Apalutamide
Darolutamide
What is the name of the SubQ injection used for the treatment of advanced prostate
cancer? - Answer Degarelix (Firmagon)
A direct LHRH antagonist
The half-life elimination is approximately 53 days.
Where did you see this?
"A non-peptide, small-molecule compound, and is
structurally distinct from GnRH analogues. It is an N-phenylurea
derivative" - Answer This is Relugolix
Selective Luteinizing Hormone-Releasing Hormone
Antagonists
The pharmacophore of NSAA is based on - Answer 4-cyano-3-trifluoromethyl-phenyl
amide
Name the PARP Inhibitor - Answer Rucaparib
Testosterone is converted to DHT by the enzyme - Answer 5α-reductase
Adverse effects of GnRH & Its Analogs - Answer Osteoporosis: Reduced bone density
• Tumor flare
• Gynecomastia
• Hot flashes
• Dyslipidemia & Hyperglycemia
• ↓Libido and ED
What are the GnRH Antagonist Analogs? - Answer Relugolix & Degarelix
Which drugs competitively inhibit the binding of testosterone & DHT? - Answer 1st gen:
Flutamide, Bicalutamide (Casodex), Nilutamide (Nilandron)
2nd gen: Apalutamide (Erleada), Darolutamide (Nubeqa) and Enzalutamide (Xtandi)
Which drugs may cause gynecomastia? - Answer Bicalutamide
Nilutamide
Which class of drugs will decrease PSA levels? - Answer Corticosteroids
(Dexamethasone, Prednisone, Methylprednisolone)
What are the Inhibitors of Poly (ADP-Ribose) Polymerase (PARP)? - Answer Olaparib
(Lynparza)
Rucaparib (Rubraca)
, What are the Nonsteroidal Antiandrogens? - Answer Bicalutamide
Flutamide
Nilutamide
Enzalutamide
Apalutamide
Darolutamide
What is the name of the SubQ injection used for the treatment of advanced prostate
cancer? - Answer Degarelix (Firmagon)
A direct LHRH antagonist
The half-life elimination is approximately 53 days.
Where did you see this?
"A non-peptide, small-molecule compound, and is
structurally distinct from GnRH analogues. It is an N-phenylurea
derivative" - Answer This is Relugolix
Selective Luteinizing Hormone-Releasing Hormone
Antagonists
The pharmacophore of NSAA is based on - Answer 4-cyano-3-trifluoromethyl-phenyl
amide
Name the PARP Inhibitor - Answer Rucaparib
