Research, 4th Edition Nathe - Updated 2024 - All
Chapters Included
State the three (3) most important characteristics of any drug. -
ANSWER> effectiveness, safety, selectivity
Is it possible to have a selective drug? - ANSWER> No, all
medications have side effects
Define the four phases of pharmacokenetics. - ANSWER>
Absorption, distribution, metabolism and excretion
Define pharmacodynamics. - ANSWER> The nature and
intensity of the response the drug has on the body
Name the three most important goals of pre-administration
assessment. - ANSWER> Evaluate effects, identify high risk
patients, and assess for self care
What factors can predispose an individual to adverse reactions
from drugs? - ANSWER> Allergies, pregnancy, age, genetics and
pathological disease (kidney or liver)
What measures help reduce adverse reactions of medication
administration? - ANSWER> A thorough patient history to
identify those who might be high risk and education
,What type of research is required to assess drug therapies? -
ANSWER> A randomized control trial is required for all new
medications
What is a "blinded" study? - ANSWER> Participants don't know
if they belong to the control or experimental group
Which Amendment strengthened drug regulation after the
Thalidomide tragedy in Europe? - ANSWER> Harris-Kefauver
Amendment to the FDA and the Cosmetic act of 1962
What is the purpose of having a trade name (proprietary or
brand name) for a drug? - ANSWER> Trade names are easy to
recall and pronounce, and good for marketing purposes
What is one of the problems with trade names? - ANSWER>
Using two brand name drugs that have the same ingredient can
lead to overdose
Binds and blocks peptidases? - ANSWER> Penicillin's
commonly used to treat urinary tract infections? - ANSWER>
Floroquinolones
inhibits cell wall synthesis - ANSWER> Cephalosporins
prevents translocation - ANSWER> Macrolides
Beta Lactam ring - ANSWER> Penicillin
, inhibits folic acid synthesis - ANSWER> Sulfonomides
Has a disulfiram like reaction when taken with alcohol -
ANSWER> Cephalosporins
Gram positive - ANSWER> Macrolides
causes prolonged QT interval - ANSWER> Flouroquinolones
Causes GI upset, hepatotoxicity, flatulence, jaundice, anorexia
and adverse effects - ANSWER> Macrolides
Causes teeth discoloration - ANSWER> Tetracycline
Associated with spontaneous tendon rupture - ANSWER>
Floroquinolones
Inhibits the process of translation - ANSWER> Aminoglycosides
inhibits DNA gyrase - ANSWER> Floroquinolones
Broad spectrum change shape of 30s sub unit - ANSWER>
Amnioglycosides
inhibits cell wall production - ANSWER> Penicillin
interferes with tRNA attachment - ANSWER> Tetracycline