GMS 6530 Hyperlipidemia Exam With Actual Questions And Verified Detailed Answers By Experts Latest Update

GMS 6530 Hyperlipidemia Exam With Actual Questions And Verified
Detailed Answers By Experts Latest Update


Chylomicrons - Answer - largest

- primarily triglycerides

- short life span

- degraded by LPL



VLDL - Answer - primarily triglycerides



IDL - Answer - cholesterol

- triglycerides



LDL - Answer - cholesterol

- bad



HDL - Answer - apolipoproteins

- little cholesterol

- good



LPL - Answer - lipoprotein lipase

- degrades lipoproteins to free fatty acids

- reduces triglyceride levels



LDL receptors - Answer - decline with age

- located in liver

, - regulate plasma cholesterol levels



Statins - Answer - HMG-coA reductase inhibitors

- or's & ol's

- reduce cholesterol synthesis

- most effective in reducing LDL

- work in hepatocytes



Statins indirect action - Answer - increase LDL receptors > increasing extraction of LDL
by liver, decreasing plasma concentration

- small decrease in VLDL (triglycerides) & HDL

-

Statin use - Answer - hypercholesterolemia (increased LDL)

- mixed hyperlipidemia (increased LDL & VLDL)

- first line after MI



Statin side effects - Answer - risk of diabetes increased

- cognative impairment-usually short term

- hepatitis-increase in hepatic enzymes

- myalgia-muscle pain

- discontinue if creatine phosphokinase is elevated or myopathy-rhabdo or
myoglobinuria



Niacin - Answer - vitamin B3-nicotinic acid

- inhibits lipolysis in adipose > decreasing FFA supply to liver & VLDL synthesis

- increases LPL activity > lowering plasma VLDL conc.

- increases plasma HDL

mixed hyperlidemia