2024 /2025 | © copyright | This work may not be copied for profit gain Excel!
NPLEX II Pharmacology Questions and
Correct Answers | Latest Update
5-fluorouracil
✓ -:- SE: Inflammation of mouth, loss of appetite, low blood cells,
inflammation of skin, hair loss.
Use: Cancer, Actinic Keratosis, BCC
Interactions/CI: Don't use in pregnancy, bone marrow suppression.
Mechanism: Antimetabolite, pyrimidine analog.
Delivery: Injectable for cancer, cream for actinic keratosis, BCC.
Amantadine
✓ -:- SE: CNS such as anxiety and difficulty swallowing. , seizures.
Use: Anti viral, but mostly anti-parkinson
1|P a g e | G r a d e A + | 2 0 2 0 2 5
,2024 /2025 | © copyright | This work may not be copied for profit gain Excel!
Interactions: Used in tandem with L-Dopa for parkinsons, Interacts with HCT, anti
depressents.
Mechanism: Antagonist of NMDA glutamate receptor, increases dopamine and blocks
reuptake.
Delivery:
Amiodarone
✓ -:- SE: Liver issues, arrhythmias, vision, thyroid and teeth issues. Wolff
Chaikoff due to iodine content.
Use: Antiarrhythmic for VT, VF, and AF.
Interactions: Danger with digitalis. . Potentiates Warfarin, CP450. No use with cyclosporine,
flecainide, procainamide etc.
Contraindicated: with Sinus nodal bradycardia, atrioventricular block and secondary or
tertiary block without a pacemaker.
2|P a g e | G r a d e A + | 2 0 2 0 2 5
,2024 /2025 | © copyright | This work may not be copied for profit gain Excel!
Mechanism: Increases time before heart cells can contract. Phase 3 prolongs refractory
period at SA and AV node.
Acyclovir
✓ -:- SE: Nausea, diarrhoea, safe in pregnancy, low platelets.
Use: Antivirals for HSV, shingles, cytomegalovirus, epstien Barr.
Interactions: synergy with ketoconazole. Probenecid extends. Same with interferon and
zidovudine.
C/I:
Mechanism: analog of guanisine, decreases viral DNA.
Adalimumab
✓ -:- SE: Increases risk of infections, blood disorders, lymphoma, cancer,
liver injury.
3|P a g e | G r a d e A + | 2 0 2 0 2 5
, 2024 /2025 | © copyright | This work may not be copied for profit gain Excel!
Use: Used in RA, psoriasis, ankylosing spondylitis, crohn's UC.
Interactions: doubles effect of methotrexate.
CI: Infections
Mechanism: TNF inhibiting anti-inflammatory biologic.
Adefovir
✓ -:- SE: Kidney toxicity in high dosages. Lactic acidosis
Use: Chronic Hep B. HSV
Interactions:
CI: Kidney disease
4|P a g e | G r a d e A + | 2 0 2 0 2 5
NPLEX II Pharmacology Questions and
Correct Answers | Latest Update
5-fluorouracil
✓ -:- SE: Inflammation of mouth, loss of appetite, low blood cells,
inflammation of skin, hair loss.
Use: Cancer, Actinic Keratosis, BCC
Interactions/CI: Don't use in pregnancy, bone marrow suppression.
Mechanism: Antimetabolite, pyrimidine analog.
Delivery: Injectable for cancer, cream for actinic keratosis, BCC.
Amantadine
✓ -:- SE: CNS such as anxiety and difficulty swallowing. , seizures.
Use: Anti viral, but mostly anti-parkinson
1|P a g e | G r a d e A + | 2 0 2 0 2 5
,2024 /2025 | © copyright | This work may not be copied for profit gain Excel!
Interactions: Used in tandem with L-Dopa for parkinsons, Interacts with HCT, anti
depressents.
Mechanism: Antagonist of NMDA glutamate receptor, increases dopamine and blocks
reuptake.
Delivery:
Amiodarone
✓ -:- SE: Liver issues, arrhythmias, vision, thyroid and teeth issues. Wolff
Chaikoff due to iodine content.
Use: Antiarrhythmic for VT, VF, and AF.
Interactions: Danger with digitalis. . Potentiates Warfarin, CP450. No use with cyclosporine,
flecainide, procainamide etc.
Contraindicated: with Sinus nodal bradycardia, atrioventricular block and secondary or
tertiary block without a pacemaker.
2|P a g e | G r a d e A + | 2 0 2 0 2 5
,2024 /2025 | © copyright | This work may not be copied for profit gain Excel!
Mechanism: Increases time before heart cells can contract. Phase 3 prolongs refractory
period at SA and AV node.
Acyclovir
✓ -:- SE: Nausea, diarrhoea, safe in pregnancy, low platelets.
Use: Antivirals for HSV, shingles, cytomegalovirus, epstien Barr.
Interactions: synergy with ketoconazole. Probenecid extends. Same with interferon and
zidovudine.
C/I:
Mechanism: analog of guanisine, decreases viral DNA.
Adalimumab
✓ -:- SE: Increases risk of infections, blood disorders, lymphoma, cancer,
liver injury.
3|P a g e | G r a d e A + | 2 0 2 0 2 5
, 2024 /2025 | © copyright | This work may not be copied for profit gain Excel!
Use: Used in RA, psoriasis, ankylosing spondylitis, crohn's UC.
Interactions: doubles effect of methotrexate.
CI: Infections
Mechanism: TNF inhibiting anti-inflammatory biologic.
Adefovir
✓ -:- SE: Kidney toxicity in high dosages. Lactic acidosis
Use: Chronic Hep B. HSV
Interactions:
CI: Kidney disease
4|P a g e | G r a d e A + | 2 0 2 0 2 5
