and Answers 100% Correct
Overview of Clindamycin - ANSWER - -Time dependent killing
-Bacteriostatic
-PO/Parental
-Rapid/complete absorption
MOA of clindamycin - ANSWER - inhibits protein synthesis
ADE of clindamycin - ANSWER - -skin rash
-neutropenia
-hepatic dysfunction
*-C. DIFF*
Clindamycin indications - ANSWER - -Gram+
-Backup for CAP
-Endocarditis in valve pts
-anaerobes
Linezolid (Zyvox) - ANSWER - -Oxazolidinone
-PO/Parenteral
-Time dependent killing
-bacteriostatic
MOA: inhibits protein synthesis and prevents formation of ribosome complex
Linezolid pharmacokinetics - ANSWER - -oral (bioavailability almost 100%) and IV
-30% CSF penetration