BS161 Exam II 2024| Questions solved
100% Correct/Verified Solutions
Which of the following would stop the cell cycle and why would it stop the cell cycle? -
ANSWER A mutation that prevents CDK from binding ATP because it would prevent
phosphorylation of target proteins needed to pass checkpoints.
Consider the cartoons from ICA DNA replication, Activity 2. Which is true about the
upper strand of cartoon 1? - ANSWER During replication, it is the template for both
a leading strand and a lagging strand.
The model above shows a CDK protein interacting with a cyclin protein. The blue and
black circles represent specific amino acids in the CDK and cyclin proteins,
respectively, that form a favorable intermolecular force.
If the blue circle represents aspartic acid, which amino acid is most likely represented
by the black circle? - ANSWER Lysine, because its R group has a positively charged
amino group
, The following parental (template) DNA sequence is present at the origin of replication.
What primer sequence would be added to start the replication process of this strand
in cells? - ANSWER 5'-UAGUAC-3'
Will CDK be active in G0 cells? Why or why not? - ANSWER CDK will not be active
because G0 cells are not dividing and CDK activity moves cells past cell cycle
checkpoints promoting cell division.
Based on the pathway in your Model of Ras Signaling in Cancer, which mutation would
cause an increase in cell division? - ANSWER A mutation in the transcription factor (TF)
that causes it to bind to the cyclin D promoter without being phosphorylated.
Shown below are DNA sequences that encode a gene. The spaces indicate the codons.
If one basepair in sequence A is mutated to the sequence shown for B (changed to
the red, bolded basepair), what kind of mutation results when this gene is expressed?
- ANSWER A missense mutation
A insertion mutation occurs in the DNA that results in the addition of two or three
'C' nucleotides between the 3rd and 4th nucleotides of the mRNA.
Compared to the original protein, which of these insertions would likely be most
disruptive to the tertiary protein structure, when this allele is expressed? - ANSWER The
insertion of 2 nucleotides, since this would change all amino acids in the primary
structure after the insertion, which then changes the tertiary structure
The following polypeptide is produced prior to a mutation:
N-Met-Leu-Lys-Trp-His-Glu-Ala-C
A nucleotide substitution occurs in the DNA that changes the sixth base in the coding
region of the mRNA used to produce this protein. Use the codon table and your
knowledge of the genetic code to choose the sequence below that will be produced as a
result of the mutation. - ANSWER N-Met-Leu-Lys-Trp-His-Glu-Ala-C
100% Correct/Verified Solutions
Which of the following would stop the cell cycle and why would it stop the cell cycle? -
ANSWER A mutation that prevents CDK from binding ATP because it would prevent
phosphorylation of target proteins needed to pass checkpoints.
Consider the cartoons from ICA DNA replication, Activity 2. Which is true about the
upper strand of cartoon 1? - ANSWER During replication, it is the template for both
a leading strand and a lagging strand.
The model above shows a CDK protein interacting with a cyclin protein. The blue and
black circles represent specific amino acids in the CDK and cyclin proteins,
respectively, that form a favorable intermolecular force.
If the blue circle represents aspartic acid, which amino acid is most likely represented
by the black circle? - ANSWER Lysine, because its R group has a positively charged
amino group
, The following parental (template) DNA sequence is present at the origin of replication.
What primer sequence would be added to start the replication process of this strand
in cells? - ANSWER 5'-UAGUAC-3'
Will CDK be active in G0 cells? Why or why not? - ANSWER CDK will not be active
because G0 cells are not dividing and CDK activity moves cells past cell cycle
checkpoints promoting cell division.
Based on the pathway in your Model of Ras Signaling in Cancer, which mutation would
cause an increase in cell division? - ANSWER A mutation in the transcription factor (TF)
that causes it to bind to the cyclin D promoter without being phosphorylated.
Shown below are DNA sequences that encode a gene. The spaces indicate the codons.
If one basepair in sequence A is mutated to the sequence shown for B (changed to
the red, bolded basepair), what kind of mutation results when this gene is expressed?
- ANSWER A missense mutation
A insertion mutation occurs in the DNA that results in the addition of two or three
'C' nucleotides between the 3rd and 4th nucleotides of the mRNA.
Compared to the original protein, which of these insertions would likely be most
disruptive to the tertiary protein structure, when this allele is expressed? - ANSWER The
insertion of 2 nucleotides, since this would change all amino acids in the primary
structure after the insertion, which then changes the tertiary structure
The following polypeptide is produced prior to a mutation:
N-Met-Leu-Lys-Trp-His-Glu-Ala-C
A nucleotide substitution occurs in the DNA that changes the sixth base in the coding
region of the mRNA used to produce this protein. Use the codon table and your
knowledge of the genetic code to choose the sequence below that will be produced as a
result of the mutation. - ANSWER N-Met-Leu-Lys-Trp-His-Glu-Ala-C
