Clinical Immunology
& Serology-detailed
Exam I
3 loci in each region - answer ✅✅-Class I: A, B, + C
-Class II: DR, DP, DQ
4 parts to phagocytosis - answer ✅✅-Phagosome
-Phagolysosome
-Opsonized
-Physical contact between WBC & foreign substance
-Formation of phagosome
-Fusion with cytoplasmic granules to become phagolysosome
-Digestion & release of debris
,4 signs of inflammation - answer ✅✅Heat, swelling, redness, and
pain
A1AT (Alpha 1 antitrypsin) - answer ✅✅-Acute-Phase Reactant
-Increase: 2-5x
-Function: Inhibits neutrophil elastase to prevent degradation of
lung tissue
Abbreviation for antigen - answer ✅✅ag
Acquired Immune System - answer ✅✅-Highly specific
-Have to see antigen before
-Related to body remembering seeing an antigen before
Activated B - answer ✅✅-B Cell differentiation
-Antigen dependent
-CD25
-When B cells activated they become blast cells
-Blasts-Give rise to memory cells and plasma cells
, Active immunity - answer ✅✅-Exposure to antigen (ag) and make
own antibodies
-Response:Days to weeks
-Results usually life long immunity
Acute Phase Reactions - answer ✅✅-Normal serum proteins that
increase rapidly as a result of infection, injury, or trauma to the
tissues.
-Systemic response
-Mediated by interleukins and cytokines
-Symptoms: -Positive acute phase reactants (APR's):Increase
-Neg APR's: Decrease
After they are produced where do lymphocytes go - answer ✅✅-Go
to secondary lymphoorgans: spleen, lymph nodes, thymus
Ag Activation - answer ✅✅T cell differentiation
All stages of B cell development have - answer ✅✅-CD19, CD24,
CD44R
allele - answer ✅✅Multiple versions of a gene
Alloantigens - answer ✅✅-Type of antigen
& Serology-detailed
Exam I
3 loci in each region - answer ✅✅-Class I: A, B, + C
-Class II: DR, DP, DQ
4 parts to phagocytosis - answer ✅✅-Phagosome
-Phagolysosome
-Opsonized
-Physical contact between WBC & foreign substance
-Formation of phagosome
-Fusion with cytoplasmic granules to become phagolysosome
-Digestion & release of debris
,4 signs of inflammation - answer ✅✅Heat, swelling, redness, and
pain
A1AT (Alpha 1 antitrypsin) - answer ✅✅-Acute-Phase Reactant
-Increase: 2-5x
-Function: Inhibits neutrophil elastase to prevent degradation of
lung tissue
Abbreviation for antigen - answer ✅✅ag
Acquired Immune System - answer ✅✅-Highly specific
-Have to see antigen before
-Related to body remembering seeing an antigen before
Activated B - answer ✅✅-B Cell differentiation
-Antigen dependent
-CD25
-When B cells activated they become blast cells
-Blasts-Give rise to memory cells and plasma cells
, Active immunity - answer ✅✅-Exposure to antigen (ag) and make
own antibodies
-Response:Days to weeks
-Results usually life long immunity
Acute Phase Reactions - answer ✅✅-Normal serum proteins that
increase rapidly as a result of infection, injury, or trauma to the
tissues.
-Systemic response
-Mediated by interleukins and cytokines
-Symptoms: -Positive acute phase reactants (APR's):Increase
-Neg APR's: Decrease
After they are produced where do lymphocytes go - answer ✅✅-Go
to secondary lymphoorgans: spleen, lymph nodes, thymus
Ag Activation - answer ✅✅T cell differentiation
All stages of B cell development have - answer ✅✅-CD19, CD24,
CD44R
allele - answer ✅✅Multiple versions of a gene
Alloantigens - answer ✅✅-Type of antigen
