SCI 225
PATHOPHYSIOLOGY
Week 13: Oncology
CONTENT REVIEW EXAM
©Nightingale 2024/2025
,1. Multiple Choice: Which oncogene is most commonly associated
with the development of breast cancer?
a) BRCA1
b) MYC
c) HER2
d) P53
Answer: c) HER2
Rationale: The HER2 oncogene is known for its overexpression
in approximately 20% of breast cancers, which can lead to
aggressive tumor growth.
2. Fill-in-the-Blank: The process by which a tumor promotes the
growth of new blood vessels is known as __________.
Answer: Angiogenesis
Rationale: Angiogenesis is a vital process for tumor growth, as it
supplies the tumor with the necessary nutrients and oxygen through
the blood vessels.
3. True/False: Metastasis is the initial stage of cancer development.
Answer: False
©Nightingale 2024/2025
, Rationale: Metastasis refers to the spread of cancer cells from the
primary site to distant organs, which is a later stage in cancer
progression.
4. Multiple Response: Select all the factors that contribute to
oncogenesis:
a) Genetic mutations
b) Chronic inflammation
c) Hormonal imbalances
d) Viral infections
Answers: a), b), c), and d)
Rationale: All listed factors can contribute to the development of
cancer by altering cellular regulation and promoting uncontrolled
cell growth.
5. Multiple Choice: What is the primary role of tumor suppressor
genes?
a) Promoting cell division
b) Suppressing immune response
c) Inhibiting cell growth
d) Enhancing angiogenesis
Answer: c) Inhibiting cell growth
©Nightingale 2024/2025
PATHOPHYSIOLOGY
Week 13: Oncology
CONTENT REVIEW EXAM
©Nightingale 2024/2025
,1. Multiple Choice: Which oncogene is most commonly associated
with the development of breast cancer?
a) BRCA1
b) MYC
c) HER2
d) P53
Answer: c) HER2
Rationale: The HER2 oncogene is known for its overexpression
in approximately 20% of breast cancers, which can lead to
aggressive tumor growth.
2. Fill-in-the-Blank: The process by which a tumor promotes the
growth of new blood vessels is known as __________.
Answer: Angiogenesis
Rationale: Angiogenesis is a vital process for tumor growth, as it
supplies the tumor with the necessary nutrients and oxygen through
the blood vessels.
3. True/False: Metastasis is the initial stage of cancer development.
Answer: False
©Nightingale 2024/2025
, Rationale: Metastasis refers to the spread of cancer cells from the
primary site to distant organs, which is a later stage in cancer
progression.
4. Multiple Response: Select all the factors that contribute to
oncogenesis:
a) Genetic mutations
b) Chronic inflammation
c) Hormonal imbalances
d) Viral infections
Answers: a), b), c), and d)
Rationale: All listed factors can contribute to the development of
cancer by altering cellular regulation and promoting uncontrolled
cell growth.
5. Multiple Choice: What is the primary role of tumor suppressor
genes?
a) Promoting cell division
b) Suppressing immune response
c) Inhibiting cell growth
d) Enhancing angiogenesis
Answer: c) Inhibiting cell growth
©Nightingale 2024/2025
