NURS 6630 Psychopharmacology Midterm Exam
2024 QUESTIONS & ANSWERS | WALDEN
UNIVERSITY
This class of antidepressants is especially cardiotoxic and may cause arrhythmias and
prolonged QT interval: - TCAs
Treatment of cardiotoxicity from TCAs: - Sodium Bicarbonate
The three most common causes of death from TCAs (The 3C's): - Convulsion, Coma,
and Cardiotoxicity
This class of antidepressants inhibits Cytochrome P450 Enzymes: - TCAs
Combining these substances with Cytochrome P450 enzyme inhibitors can result in
severe respiratory depression and death due to toxic levels: - Ethanol and sedative
hypnotics (benzos)
These two neuron types have abundant Alpha 2 receptors: - Noradrenergic and
Serotonergic
When stimulated Alpha 2 receptors inhibit the activity of the presynaptic neuron and
decrease the release of these two neurotransmitters: - Norepinephrine and Serotonin
Six common Atypical Antidepressants used for individuals that did not respond to other
antidepressants: - mirtazapine, trazadone, nefazodone, vilazodone, vortioxetine,
bupropion
This antidepressant effects Alpha 2 receptors, 5-HT2A receptors, 5-HT3A receptors,
and Histamine H1 receptors: - mirtazapine
The primary antidepressant action of this drug comes from inhibition of the Alpha 2
receptors, which reduces the inhibition of the synaptic neuron, and thus increases
Norepinephrine and Serotonin release - mirtazapine
As a Serotonin Antagonist, this Atypical Antidepressant blocks 5-HT2A and 5-HT3A
receptors to increase the amount of Serotonin available to bind to 5-HT1A receptors
which are more strongly linked to depression: - mirtazapine
Mirtazapine's inhibition of 5-HT3A receptors reduces: - nausea and vomiting
, Mirtazapine's inhibition of Histamine H1 receptors causes: - sedation (could be
desirable side effect for depressed individuals with insomnia)
For depressed individuals with anorexia, increased appetite and weight gain, are
possibly beneficial side effects of this Atypical Antidepressant: - mirtazapine
As Serotonin Antagonists, these two Atypical Antidepressants block 5-HT2A receptors
so that more Serotonin is available to bind to 5-HT1A receptors which are more strongly
linked to depression: - trazodone and nefazodone
In addition to inhibition of 5-HT2A receptors, these two Atypical Antidepressants
increase levels of Serotonin in the synaptic cleft through weak inhibition of Serotonin
reuptake transporters: - trazodone and nefazodone
These two Atypical Antidepressants are strong H1 receptor inhibitors, and therefore
commonly used to treat insomnia: - trazodone and nefazodone
These two Atypical Antidepressants may cause orthostatic hypotension and priapism
through Alpha-1 receptor inhibition: - trazodone and nefazodone
In rare cases, this Atypical Antidepressant is known to cause severe liver damage: -
nefazodone
Similar to SSRIs, these two Atypical Antidepressants are strong inhibitors of Serotonin
reuptake transporters on the presynaptic neuron: - vilazodone and vortioxetine
These two Atypical Antidepressants bind to and stimulate 5-HT1A receptors: -
vilazodone (partial agonist) and vortioxetine (full agonist)
Vilazodone or Vortioxetine, which of these Atypical Antidepressants is a partial
agonist?: - vilazodone
Vilazodone or Vortioxetine, which of these Atypical Antidepressants is a full agonist?: -
vortioxetine
Since they enhance the effects of Serotonin through two different mechanisms, these
two Atypical Antidepressants can cause serotonin syndrome: - vilazodone and
vortioxetine
Six common side effects of vilazodone (primarily anticholinergic, **unique to
vilazodone**): - sedation, blurred vision, orthostatic hypotension, urinary retention,
tachycardia, **weight gain**
2024 QUESTIONS & ANSWERS | WALDEN
UNIVERSITY
This class of antidepressants is especially cardiotoxic and may cause arrhythmias and
prolonged QT interval: - TCAs
Treatment of cardiotoxicity from TCAs: - Sodium Bicarbonate
The three most common causes of death from TCAs (The 3C's): - Convulsion, Coma,
and Cardiotoxicity
This class of antidepressants inhibits Cytochrome P450 Enzymes: - TCAs
Combining these substances with Cytochrome P450 enzyme inhibitors can result in
severe respiratory depression and death due to toxic levels: - Ethanol and sedative
hypnotics (benzos)
These two neuron types have abundant Alpha 2 receptors: - Noradrenergic and
Serotonergic
When stimulated Alpha 2 receptors inhibit the activity of the presynaptic neuron and
decrease the release of these two neurotransmitters: - Norepinephrine and Serotonin
Six common Atypical Antidepressants used for individuals that did not respond to other
antidepressants: - mirtazapine, trazadone, nefazodone, vilazodone, vortioxetine,
bupropion
This antidepressant effects Alpha 2 receptors, 5-HT2A receptors, 5-HT3A receptors,
and Histamine H1 receptors: - mirtazapine
The primary antidepressant action of this drug comes from inhibition of the Alpha 2
receptors, which reduces the inhibition of the synaptic neuron, and thus increases
Norepinephrine and Serotonin release - mirtazapine
As a Serotonin Antagonist, this Atypical Antidepressant blocks 5-HT2A and 5-HT3A
receptors to increase the amount of Serotonin available to bind to 5-HT1A receptors
which are more strongly linked to depression: - mirtazapine
Mirtazapine's inhibition of 5-HT3A receptors reduces: - nausea and vomiting
, Mirtazapine's inhibition of Histamine H1 receptors causes: - sedation (could be
desirable side effect for depressed individuals with insomnia)
For depressed individuals with anorexia, increased appetite and weight gain, are
possibly beneficial side effects of this Atypical Antidepressant: - mirtazapine
As Serotonin Antagonists, these two Atypical Antidepressants block 5-HT2A receptors
so that more Serotonin is available to bind to 5-HT1A receptors which are more strongly
linked to depression: - trazodone and nefazodone
In addition to inhibition of 5-HT2A receptors, these two Atypical Antidepressants
increase levels of Serotonin in the synaptic cleft through weak inhibition of Serotonin
reuptake transporters: - trazodone and nefazodone
These two Atypical Antidepressants are strong H1 receptor inhibitors, and therefore
commonly used to treat insomnia: - trazodone and nefazodone
These two Atypical Antidepressants may cause orthostatic hypotension and priapism
through Alpha-1 receptor inhibition: - trazodone and nefazodone
In rare cases, this Atypical Antidepressant is known to cause severe liver damage: -
nefazodone
Similar to SSRIs, these two Atypical Antidepressants are strong inhibitors of Serotonin
reuptake transporters on the presynaptic neuron: - vilazodone and vortioxetine
These two Atypical Antidepressants bind to and stimulate 5-HT1A receptors: -
vilazodone (partial agonist) and vortioxetine (full agonist)
Vilazodone or Vortioxetine, which of these Atypical Antidepressants is a partial
agonist?: - vilazodone
Vilazodone or Vortioxetine, which of these Atypical Antidepressants is a full agonist?: -
vortioxetine
Since they enhance the effects of Serotonin through two different mechanisms, these
two Atypical Antidepressants can cause serotonin syndrome: - vilazodone and
vortioxetine
Six common side effects of vilazodone (primarily anticholinergic, **unique to
vilazodone**): - sedation, blurred vision, orthostatic hypotension, urinary retention,
tachycardia, **weight gain**
