Advanced Pharmacology-NR 508 Questions and answers | Updated 2024/25

Advanced Pharmacology-NR 508
Questions and answers | Updated
2024/25
State the three (3) most important characteristics of any drug. - effectiveness, safety,
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selectivity
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II Is it possible to have a selective drug? - No, all medications have side effects
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Define the four phases of pharmacokenetics. - Absorption, distribution, metabolism and
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excretion
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Define pharmacodynamics. - The nature and intensity of the response the drug has on
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the body
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Name the three most important goals of pre-administration assessment. - Evaluate
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effects, identify high risk patients, and assess for self care
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What factors can predispose an individual to adverse reactions from drugs? - Allergies,
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pregnancy, age, genetics and pathological disease (kidney or liver)
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What measures help reduce adverse reactions of medication administration? - A
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thorough patient history to identify those who might be high risk and education
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What type of research is required to assess drug therapies? - A randomized control trial
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is required for all new medications
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What is a "blinded" study? - Participants don't know if they belong to the control or
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experimental group
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Which Amendment strengthened drug regulation after the Thalidomide tragedy in
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Europe? - Harris-Kefauver Amendment to the FDA and the Cosmetic act of 1962
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What is the purpose of having a trade name (proprietary or brand name) for a drug? -
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Trade names are easy to recall and pronounce, and good for marketing purposes
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What is one of the problems with trade names? - Using two brand name drugs that have
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the same ingredient can lead to overdose
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II Binds and blocks peptidases? - Penicillin's
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II commonly used to treat urinary tract infections? - Floroquinolones II II II II II II II II II II

, II inhibits cell wall synthesis - Cephalosporins
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II prevents translocation - Macrolides II II II II II




II Beta Lactam ring - Penicillin
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II inhibits folic acid synthesis - Sulfonomides
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II Has a disulfiram like reaction when taken with alcohol - Cephalosporins
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II Gram positive - Macrolides
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II causes prolonged QT interval - Flouroquinolones
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Causes GI upset, hepatotoxicity, flatulence, jaundice, anorexia and adverse effects -
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Macrolides
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II Causes teeth discoloration - Tetracycline
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II Associated with spontaneous tendon rupture - Floroquinolones II II II II II II II II




II Inhibits the process of translation - Aminoglycosides
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II inhibits DNA gyrase - Floroquinolones
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II Broad spectrum change shape of 30s sub unit - Amnioglycosides
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II inhibits cell wall production - Penicillin
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II interferes with tRNA attachment - Tetracycline II II II II II II II




II most common antibiotic to be allergic to - Sulfonomides
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II inhibits protein synthesis - Aminoglycosides
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II The study of drugs and their actions on the body - Pharmacology
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II The first part of the drug development process
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Identification of promising drugs and testing on animals occurs in this phase - Pre clinical
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Stage
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II quantal and graded - Two types of drug responses
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biological effects that can be measured continually up to the maxium responding capacity
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of the biologic system
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