HYPERTENSION TREATMENT OVERVIEW QUESTIONS AND
ANSWERS ELABORATIONS!!
HTN Medications Order
Answers:Sequence in which hypertension medications are typically prescribed
Preferred Antihypertensives in Diabetics
Answers:ACEIs, ARBs, CCBs, and diuretics (in low doses) are recommended
Diabetic Nephropathy Treatment
Answers:ACEIs and ARBs can slow renal damage and reduce albuminuria
Antihypertensives and DM Warnings
Answers:Beta blockers mask hypoglycemia signs; thiazides promote
hyperglycemia
Pregnancy and Hypertension Medication
Answers:Avoid ACEI, ARBs, and DRIs due to fetal harm risk
Methyldopa and Labetalol
Answers:Drugs of choice for hypertension during pregnancy
Thiazide Diuretics Therapeutic Action
Answers:Decrease blood volume by blocking sodium-chloride channel in the
kidney
ACE Inhibitors Mechanism
, Answers:Inhibit ACE to decrease angiotensin II levels and lower blood pressure
ACE Inhibitors Side Effects
Answers:Can cause dry cough and angioedema due to bradykinin release
ARBs Mechanism
Answers:Bind to angiotensin receptors to prevent vasoconstriction
Dihydropyridines Action
Answers:Create vasodilation by blocking calcium channels in muscles and vessels
Ethnic Groups and Drug Impact
Answers:AA/Black patients should avoid ACE inhibitors; Asians may have high
rosuvastatin levels
Rosuvastatin
Answers:Therapeutic doses in Asians should be halved compared to Whites.
CYP3A4
Answers:Enzyme responsible for metabolizing drugs; absent in Asians.
HLA-B*1502
Answers:Unusual human leukocyte antigen linked to severe skin reactions from
carbamazepine.
Warfarin
ANSWERS ELABORATIONS!!
HTN Medications Order
Answers:Sequence in which hypertension medications are typically prescribed
Preferred Antihypertensives in Diabetics
Answers:ACEIs, ARBs, CCBs, and diuretics (in low doses) are recommended
Diabetic Nephropathy Treatment
Answers:ACEIs and ARBs can slow renal damage and reduce albuminuria
Antihypertensives and DM Warnings
Answers:Beta blockers mask hypoglycemia signs; thiazides promote
hyperglycemia
Pregnancy and Hypertension Medication
Answers:Avoid ACEI, ARBs, and DRIs due to fetal harm risk
Methyldopa and Labetalol
Answers:Drugs of choice for hypertension during pregnancy
Thiazide Diuretics Therapeutic Action
Answers:Decrease blood volume by blocking sodium-chloride channel in the
kidney
ACE Inhibitors Mechanism
, Answers:Inhibit ACE to decrease angiotensin II levels and lower blood pressure
ACE Inhibitors Side Effects
Answers:Can cause dry cough and angioedema due to bradykinin release
ARBs Mechanism
Answers:Bind to angiotensin receptors to prevent vasoconstriction
Dihydropyridines Action
Answers:Create vasodilation by blocking calcium channels in muscles and vessels
Ethnic Groups and Drug Impact
Answers:AA/Black patients should avoid ACE inhibitors; Asians may have high
rosuvastatin levels
Rosuvastatin
Answers:Therapeutic doses in Asians should be halved compared to Whites.
CYP3A4
Answers:Enzyme responsible for metabolizing drugs; absent in Asians.
HLA-B*1502
Answers:Unusual human leukocyte antigen linked to severe skin reactions from
carbamazepine.
Warfarin