BIO 340 ASU
Mangone Exam 4
Questions and
Complete Solutions
Graded A+
Denning [Date] [Course title]
, somatic mutations - Correct Ans: not heritable
germline mutations - Correct Ans: inherited
Luria and Delbruck - Correct Ans: Fluctuation test:
1) resistance is a physiological response to bacteria
2) resistance arises from random mutation only, not adaptive
3) mutations occur in the absence of selection, not because of it
neutral mutations - Correct Ans: can occur in protein coding region or other part of genome
B-thalassemia - Correct Ans: disease that arises from a large amount of mutations
Spinal muscle atrophy - Correct Ans: caused by genetic defect in SMN1; lower levels of this protein
result in loss of function in neuronal cells in spinal cord
CRISPR/Cas9 - Correct Ans: a revolutionary gene editing technique derived from the immune system of
simple prokaryotes; provides prokaryotic immunity
How prokaryotes regulate genes - Correct Ans: mechanism that turns transcription on and off based on
metabolism
Constitutive enzymes - Correct Ans: Enzymes are continuously produced regardless of chemical makeup
of environment (tRNAs, rRNAs)
Inducible enzymes - Correct Ans: created by bacteria to adapt to environment (positive and negative
control)
negative control - Correct Ans: gene expression occurs unless it is shut off by some form of a regulator
molecule
Mangone Exam 4
Questions and
Complete Solutions
Graded A+
Denning [Date] [Course title]
, somatic mutations - Correct Ans: not heritable
germline mutations - Correct Ans: inherited
Luria and Delbruck - Correct Ans: Fluctuation test:
1) resistance is a physiological response to bacteria
2) resistance arises from random mutation only, not adaptive
3) mutations occur in the absence of selection, not because of it
neutral mutations - Correct Ans: can occur in protein coding region or other part of genome
B-thalassemia - Correct Ans: disease that arises from a large amount of mutations
Spinal muscle atrophy - Correct Ans: caused by genetic defect in SMN1; lower levels of this protein
result in loss of function in neuronal cells in spinal cord
CRISPR/Cas9 - Correct Ans: a revolutionary gene editing technique derived from the immune system of
simple prokaryotes; provides prokaryotic immunity
How prokaryotes regulate genes - Correct Ans: mechanism that turns transcription on and off based on
metabolism
Constitutive enzymes - Correct Ans: Enzymes are continuously produced regardless of chemical makeup
of environment (tRNAs, rRNAs)
Inducible enzymes - Correct Ans: created by bacteria to adapt to environment (positive and negative
control)
negative control - Correct Ans: gene expression occurs unless it is shut off by some form of a regulator
molecule
