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Nursing 460- Critical Care Test 3 Questions and Answers

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Most common causes of acute liver failure toxins/drugs (esp. Acetaminophen), viral hepatitis (inflammation of the liver), vascular- hypo perfusion/ shock states/ ischemia), metabolic- Wilson's disease (acute fatty liver of pregnancy) Management of acute liver failure whichever body system(s) is/are having issues thereby causing liver injury, support that/those systems (respiratory, circulatory, neuro, coagulopathy, GI, renal, infection, metabolic) Type of liver failure primarily seen in ICU Chronic liver failure Consequence of chronic liver disease cirrhosis Most common causes of cirrhosis excessive alcohol consumption, viral hepatitis, fatty liver disease Hepatotoxicity occurs when acetaminophen dose is... 10 grams/24 hours Prolonged portal hypertension leads to the development of varices (fragile distended veins) in the lower esophagus, stomach and rectum- can lead to variceal hemorrhage; hepatorenal syndrome; ascites (accumulation of fluid in the abdomen); hepatic encephalopathy (disrupted CNS function with altered consciousness); right sided heart failure Decompensated liver disease (definition) inflammation (hepatitis) and injury to the liver resulting in severe scarring (cirrhosing) Shock systemic response to a decrease in perfusion to tissues and organs leading to poor gas and nutrition exchange Pulmonary vascular resistance (PVR) 2-120 Right ventricle resistance/afterload Systemic vascular resistance (SVR) 770-1500 Left ventricle resistance/afterload Contractility strength and volume of the pump

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Nursing 460 - Critical Care Test 3 Questions and Answers Most common causes of acute liver failure ✅toxins/drugs (esp. Acetaminophen ), viral hepatitis (inflammation of the liver), vascular - hypo perfusion/ shock states/ ischemia), metabolic - Wilson's disease (acute fatty liver of pregnancy) Management of acute liver failure ✅whichever body system(s) is/are having issues thereby causing liver injury, support that/those systems (respiratory, circulatory, neuro, coagulopathy, GI, renal, infection, metabolic) Type of liver failure primarily seen in ICU ✅Chronic liver failure Consequence of chronic liver disease ✅cirrhosis Most common causes of cirrhosis ✅excessive alcohol consumption, viral hepatitis, fatty liver disease Hepatotoxicity occurs when acetaminophen dose is... ✅>10 grams/24 hours Prolonged portal hypertension leads to the development of ✅varices (fragile distended veins) in the lower esophagus, stomach and rectum - can lead to variceal hemorrhage; hepatorenal syndrome; ascites (accumulation of fluid in the abdomen); hepatic encephalopathy (disrupted CNS function with altered consciousness); right sided heart failure Decompensated liver disease (definition) ✅inflammation (hepatitis) and injury to the liver resulting in severe scarring (cirrhosing) Shock ✅systemic response to a decrease in perfusion to tissues and organs leading to poor gas and nutrition exchange Pulmonary vascular resistance (PVR) ✅2-120 Right ventricle resistance/afterload Systemic vascular resistance (SVR) ✅770-1500 Left ventricle resistance/afterload Contractility ✅strength and volume of the pump

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