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Summary 2 Nucleic acids

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Concise nucleic acids summary notes for the new linear A-level biology 7401/7402

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Nucleic Acids


Nucleic acids
Ribonucleic acid:
- Ribose sugar
- Phosphate
- Nitrogenous bases: adenine, uracil, cytosine. guanine
- Single strand
Deoxyribonucleic acid:
- Deoxyribose sugar
- Phosphate
- Nitrogenous bases: adenine, thymine, cytosine, guanine
- Double strand


Complementary base pairing
® Cytosine pairs with guanine
® Adenine pairs with thymine or uracil




Semi-conservative replication
• DNA helicase causes the 2 strands of DNA to separate by breaking the hydrogen bonds
between complementary base pairs
• Free, activated nucleotides in the nucleoplasm specifically bind to their complementary
base pairs
• The strong sugar-phosphate backbone is re-joined by DNA polymerase, forming
phosphodiester bonds – forming 2 identical strands of DNA
• Because the strands each contain half of the original material it is called the semi-
conservative method of replication
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