Pharmacology: Antibiotics Questions and Correct Answers | Latest Update | A+

what does a bacteriostatic drug do? Ans: inhibit growth of a pathogen w/o causing cell death what does a bacteriocidal drug do? Ans: kills bacteria define post-antibiotic effect? Ans: after the administered antibiotic concentration has fallen below the bacterial MIC, suppression of bacterial growth still continues define superinfection Ans: a second "opportunistic" infection occurring during the course of antimicrobial therapy often due to the loss of normal oral/gut flora b/c antibiotics. relations between drugs and protein binding Ans: only antibiotics that are protein-free (not bound) can have antimicrobial activity what does it mean if the host neutrophils of a gram stain are purple? Ans: the gram stain was incomplete. what is the MIC Ans: the minimum inhibitory concentration: the smallest contration of drug needed to have its bacteri-cidal or -static effect what is the LADME process? Ans: pharmokinetics of antibiotics. Liberation- release of drug from dosage form, Absorption- movement of drug from admin site to blood circulation, Distribution- process drug diffuses and is transferred to body tissues, Metabolism- chemical conversions/transformation into compounds easier to eliminate, Excretion- removal of drug/metabolite from the body via renal, biliary or pulmonary process effect on drug activity with increased protein binding Ans: decreased microbial action by the drug with increased binding to protiens 3 kinetic patterns of antibiotic action Ans: 1- concentration dependent killing. maximize concentration/dose 2- time dependent killing, minimal post-antibioitic effect (PAE). change in concentration does not help. maximize tim