MD3001 Pharmacology Questions and Correct Answers | Latest Update | A+
Alternatives for acyclovir? Ans: Valaciclovir prodrug with better oral availability; ganciclovir and valganciclovir for immunocompromised patients RNA virus features Ans: Negative sense RNA complementary to mRNA and must be converted to positive sense by the host cell. Replication occurs in cytoplasm binding sites on virus Ans: Polypeptides on envelope or capsid Receptors on host cell targeted by virus Ans: Normal receptors for cytokines, hormones, NTs, ion channels, integral glycoproteins Viral lifecycle Ans: recognition, attachment, fusion/penetration, uncoating, transcription, protein synthesis, replication, envelopment/assembly, budding and release/lysis and release uncoating inhibitors Ans: Amantidine and rimantidine block M2 as ion channel Chain termination Ans: Aciclovir NRTIs Ans: abacavir, lamivudine, stauvudine, tonofir, zalcitabine, zidovudine, didanosine, emtricitabine NNRTIs Ans: delaviridine, efavirenz, etravirine, verirapine Protease inhibitors Ans: Atazanavir, indinavir, lopinavir, ritonavir, squinavir HCV protease inhibitors Ans: Boceprevir, telaprevir Integrase inhibitors
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