Mmsc 433 Final Study Guide

MMSC 433 FINAL STUDY GUIDE iron absorption - Answer--ferric iron is taken in from diet -ferric iron is reduced by duodenal cytochrome B to become ferrous iron -ferrous iron is absorbed into enterocytes by DMT 1 -absorbed iron is stored as ferritin, or sent into portal hepatic circulation and carried by transferrin to developing RBCs transferrin - Answer-plasma carrier protein for ferrous iron high iron level regulation - Answer--hepcidin is released from hepatocytes -ferroportin is inactivated, leading to decreased iron being transported into circulation low iron level regulation - Answer--hepcidin is down regulated by hepatocytes -ferroportin becomes activated and transports iron out of the enterocytes and into circulation ferrous iron - Answer-the form of iron that is able to be utilized in the body for developing red cells prussian blue stain - Answer-stain that is used to identify iron in tissues and bone marrow stage 1 iron deficiency (progressive loss of storage iron) - Answer--asymptomatic -RBCs develop normally -*serum ferritin low* stage 2 iron deficiency (exhaustion of iron storage pool) - Answer--subclinical symptoms -hemoglobin in retics is decreased, *hemogram appears normal still* -iron deficiency erythropoiesis is occurring -hepcidin decreased -serum iron and ferritin decreased -RDW, TIBC and sTRs increased -prussian blue stain of BM is negative for iron stage 3 iron deficiency (frank anemia) - Answer--patient exhibits fatigue, weakness, pallor, glossitis, koilonychia and pica -*H/H decreased* -*hypochromic/ microcytic anemia* -FEP, TIBC and sTR increased -ferritin