PUBH 6011 FINAL EXAM ///2024 UPDATED AND 100% VERIFIED ANSWERS

Dose-response relationship - ANSWER- - toxicity quantified through the dose-response relationship - individual: change in severity of effect with dose - population: change in prop. of population responding with dose --- different for different effects --- shape of curve gives information about pop. variability and tox of the compound Population dose-response function - ANSWER- - focus on a specific endpoint - test multiple individuals (mice or rats usually) at specific doses - at each dose level, individuals either do or don't respond (variation across individuals) - measure proportion of population responding at each dose level or level of response at each dose level - as dose goes up, severity goes up Variation in response to dose - ANSWER- - differences in response due to genes, nutrition, health status, etc. Tolerance distribution - ANSWER- more of the population will respond at higher doses, more of the population has tolerance to low doses How does an agent get into the body - ANSWER- route: - oral - dermal - inhalation timing: - acute (days) - sub-chronic (weeks to months) - chronic (months to years) Equivalent doses - ANSWER- - use mg/kg to make equivalent doses across species