ACE inhibitors Exam Questions and Answers

ACE inhibitors Exam Questions and Answers ACE inhibitor MOA - Correct Answer ️️ -MOA Inhibit the conversion of angiotensin-I to angiotensin-II. Angiotensin-II is a potent vasoconstrictor and promotes the production of aldosterone. Aldosterone promotes sodium and water retention. By inhibiting the production of angiotensin-II, ACE-inhibitors cause vasodilation and indirectly inhibit fluid volume increases that result from the actions of aldosterone. ACE inhibitor uses - Correct Answer ️️ -ACE inhibitors were initially approved for the treatment of hypertension, and can be used alone or in combination with other antihypertensive medications. Later, they were found useful in other cardiovascular and kidney diseases including: - Acute myocardial infarction (heart attack) - prevents cardiac remodeling - Cardiac failure (left ventricular systolic dysfunction) - Kidney complications of diabetes mellitus (diabetic nephropathy) In treating heart disease, ACE inhibitors are usually used with other medications. A typical treatment plan often includes an ACE inhibitor, a beta blocker, a long-acting nitrate, and a calcium channel blocker in combinations that are adjusted to the individual patient's needs. ACE inhibitors have also been used in chronic kidney failure and kidney involvement in systemic sclerosis (hardening of tissues, as scleroderma renal crisis)